| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 53,911 | 1,770,805 | +1,716,894 | 0.18 | 5.18 | +5.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 433,540 | 850,695 | +417,155 | 0.23 | 0.48 | +0.25 | buy |
| Avidity Partners Management LP | 1,296,225 | 1,656,000 | +359,775 | 1.74 | 3.19 | +1.45 | buy |
| Corebridge Financial, Inc. | 307,286 | 135,629 | +171,657 | 0.06 | 0.03 | 0.00 | sell |
| ADAR1 Capital Management, LLC | 12,850 | 143,104 | +130,254 | 0.08 | 0.91 | +0.82 | buy |
| JANUS HENDERSON GROUP PLC | 1,427,017 | 1,526,534 | +99,517 | 0.02 | 0.03 | 0.00 | buy |
| TimesSquare Capital Management, LLC | 343,059 | 437,069 | +94,010 | 0.17 | 0.25 | +0.08 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 106,951 | 199,983 | +93,032 | 0.03 | 0.06 | +0.03 | buy |
| Ally Bridge Group (NY) LLC | 174,876 | 263,266 | +88,390 | 3.29 | 5.32 | +2.03 | buy |
| Woodline Partners LP | 525,199 | 605,898 | +80,699 | 0.16 | 0.19 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 330,000 | 400,000 | +70,000 | 0.02 | 0.03 | +0.01 | buy |
| ArrowMark Colorado Holdings LLC | 196,259 | 230,390 | +34,131 | 0.07 | 0.11 | +0.04 | buy |
| Rafferty Asset Management, LLC | 50,965 | 78,595 | +27,630 | 0.01 | 0.01 | +0.00 | buy |
| Decheng Capital LLC | 5,458,810 | 5,478,810 | +20,000 | 52.81 | 48.96 | -3.85 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 266,787 | 279,945 | +13,158 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 9,513 | 15,857 | +6,344 | 0.01 | 0.02 | 0.00 | buy |
| ALPS ADVISORS INC | 51,981 | 53,859 | +1,878 | 0.01 | 0.01 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 10,000 | 11,024 | +1,024 | 0.02 | 0.03 | 0.00 | buy |
| NEOS Investment Management LLC | 7,039 | 7,512 | +473 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,601 | 2,648 | +47 | 0.04 | 0.05 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 93,084 | 70,836 | -22,248 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 335,310 | 309,296 | -26,014 | 0.66 | 0.72 | +0.06 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 665,145 | 591,407 | -73,738 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 424,585 | 340,585 | -84,000 | 1.18 | 1.07 | -0.11 | sell |
| BRAIDWELL LP | 3,309,507 | 3,170,875 | -138,632 | 3.28 | 3.39 | +0.11 | sell |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 915,501 | 495,526 | -419,975 | 96.44 | 92.93 | -3.51 | sell |
| Yu Fan | 1,578,344 | 163,456 | -1,414,888 | 65.11 | 18.99 | -46.12 | sell |
| BVF INC/IL | 2,417,885 | 994,596 | -1,423,289 | 2.14 | 1.10 | -1.04 | sell |