| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 2,244,121 | 5,081,352 | +2,837,231 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 53,911 | 1,770,805 | +1,716,894 | 0.18 | 5.18 | +5.00 | buy |
| STATE STREET CORP | 982,931 | 1,700,653 | +717,722 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 691,114 | +691,114 | 0.00 | 0.48 | +0.48 | buy |
| Point72 Asset Management, L.P. | 110,410 | 746,063 | +635,653 | 0.01 | 0.10 | +0.09 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 549,778 | 1,078,527 | +528,749 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 520,119 | +520,119 | 0.00 | 7.01 | +7.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 433,540 | 850,695 | +417,155 | 0.23 | 0.48 | +0.25 | buy |
| Avidity Partners Management LP | 1,296,225 | 1,656,000 | +359,775 | 1.74 | 3.19 | +1.45 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 201,367 | 510,219 | +308,852 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 177,402 | 379,664 | +202,262 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 183,980 | 381,441 | +197,461 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 471,090 | 649,574 | +178,484 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 174 | 145,606 | +145,432 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 94,709 | 234,871 | +140,162 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 57,551 | 195,951 | +138,400 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 12,850 | 143,104 | +130,254 | 0.08 | 0.91 | +0.82 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 37,962 | 153,814 | +115,852 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,009,783 | 1,124,905 | +115,122 | 0.01 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 56,195 | 170,892 | +114,697 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,130,087 | 1,230,193 | +100,106 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,427,017 | 1,526,534 | +99,517 | 0.02 | 0.03 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 343,059 | 437,069 | +94,010 | 0.17 | 0.25 | +0.08 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 106,951 | 199,983 | +93,032 | 0.03 | 0.06 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 91,062 | +91,062 | 0.00 | 0.03 | +0.03 | buy |
| Ally Bridge Group (NY) LLC | 174,876 | 263,266 | +88,390 | 3.29 | 5.32 | +2.03 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 83,000 | +83,000 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 525,199 | 605,898 | +80,699 | 0.16 | 0.19 | +0.03 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 330,000 | 400,000 | +70,000 | 0.02 | 0.03 | +0.01 | buy |
| BARCLAYS PLC | 20,997 | 90,520 | +69,523 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 89,344 | 144,926 | +55,582 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 37,759 | +37,759 | 0.00 | 0.02 | +0.02 | buy |
| ArrowMark Colorado Holdings LLC | 196,259 | 230,390 | +34,131 | 0.07 | 0.11 | +0.04 | buy |
| RHUMBLINE ADVISERS | 34,229 | 67,558 | +33,329 | 0.00 | 0.00 | +0.00 | buy |
| Neo Ivy Capital Management | 0 | 29,678 | +29,678 | 0.00 | 0.36 | +0.36 | buy |
| Rafferty Asset Management, LLC | 50,965 | 78,595 | +27,630 | 0.01 | 0.01 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 25,800 | +25,800 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 10,609 | 35,206 | +24,597 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,729 | 26,660 | +23,931 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 22,596 | +22,596 | 0.00 | 0.11 | +0.11 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 22,052 | +22,052 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 5,458,810 | 5,478,810 | +20,000 | 52.81 | 48.96 | -3.85 | buy |
| SG Americas Securities, LLC | 0 | 17,595 | +17,595 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,308 | 29,054 | +15,746 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 15,734 | +15,734 | 0.00 | 0.20 | +0.20 | buy |
| DEUTSCHE BANK AG\ | 9,827 | 25,389 | +15,562 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,352 | 27,132 | +13,780 | 0.00 | 0.01 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 266,787 | 279,945 | +13,158 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 12,993 | +12,993 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,301 | 73,149 | +12,848 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 19,529 | 31,071 | +11,542 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 9,282 | +9,282 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 8,962 | +8,962 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,546 | 19,431 | +8,885 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 78,080 | 86,534 | +8,454 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 0 | 7,890 | +7,890 | 0.00 | 0.02 | +0.02 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 7,821 | 15,003 | +7,182 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 6,399 | +6,399 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 9,513 | 15,857 | +6,344 | 0.01 | 0.02 | +0.01 | buy |
| M&T BANK CORP | 10,762 | 16,758 | +5,996 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 5,792 | +5,792 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 5,616 | +5,616 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 19,135 | 24,397 | +5,262 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 12,406 | 15,407 | +3,001 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,320 | 4,805 | +2,485 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 10,476 | 12,895 | +2,419 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 51,981 | 53,859 | +1,878 | 0.01 | 0.01 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,596 | 11,996 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,227 | +1,227 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,645 | 2,719 | +1,074 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 10,000 | 11,024 | +1,024 | 0.01 | 0.01 | +0.00 | buy |
| AMALGAMATED BANK | 781 | 1,621 | +840 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 7,039 | 7,512 | +473 | 0.01 | 0.01 | -0.00 | buy |
| GAMMA Investing LLC | 0 | 106 | +106 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,601 | 2,648 | +47 | 0.04 | 0.05 | +0.01 | buy |
| BESSEMER GROUP INC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 12 | 34 | +22 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 46 | 68 | +22 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 17 | +17 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 10 | 25 | +15 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorNet Financial, Inc | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 733,695 | 733,695 | 0 | 0.56 | 0.59 | +0.03 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 1,397,433 | 1,397,433 | 0 | 0.58 | 0.61 | +0.02 | hold |
| Ensign Peak Advisors, Inc | 60,565 | 60,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 1,344,074 | 1,344,074 | 0 | 0.66 | 0.73 | +0.08 | hold |
| Cormorant Asset Management, LP | 975,000 | 975,000 | 0 | 1.79 | 1.95 | +0.16 | hold |
| Avoro Capital Advisors LLC | 700,000 | 700,000 | 0 | 0.29 | 0.39 | +0.09 | hold |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.30 | 0.33 | +0.03 | hold |
| Foresite Capital Management V, LLC | 692,550 | 692,550 | 0 | 13.96 | 18.16 | +4.20 | hold |
| Polar Capital Holdings Plc | 967,055 | 967,055 | 0 | 0.18 | 0.17 | -0.01 | hold |
| TCG Crossover Management, LLC | 3,670,206 | 3,670,206 | 0 | 12.08 | 11.73 | -0.34 | hold |
| Frazier Life Sciences Management, L.P. | 770,000 | 770,000 | 0 | 1.14 | 1.16 | +0.03 | hold |
| Washington Trust Advisors, Inc. | 49 | 49 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Covestor Ltd | 4 | 4 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Strengthening Families & Communities, LLC | 1,000 | 1,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| COMERICA BANK | 55 | 55 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Avior Wealth Management, LLC | 80 | 0 | -80 | 0.00 | 0.00 | -0.00 | sell |
| Headlands Technologies LLC | 143 | 0 | -143 | 0.00 | 0.00 | -0.00 | sell |