| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 1,898,894 | 5,512,779 | +3,613,885 | 0.01 | 0.04 | +0.03 | buy |
| VANGUARD GROUP INC | 5,906,511 | 6,577,281 | +670,770 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 0 | 613,852 | +613,852 | 0.00 | 0.02 | +0.02 | buy |
| Candriam S.C.A. | 763,580 | 1,037,892 | +274,312 | 0.11 | 0.22 | +0.10 | buy |
| DIMENSIONAL FUND ADVISORS LP | 259,211 | 452,351 | +193,140 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 25,573 | 208,012 | +182,439 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,187,101 | 1,366,871 | +179,770 | 0.00 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 175,000 | +175,000 | 0.00 | 0.32 | +0.32 | buy |
| JPMORGAN CHASE & CO | 54,094 | 227,879 | +173,785 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 157,874 | +157,874 | 0.00 | 0.54 | +0.54 | buy |
| Opaleye Management Inc. | 266,000 | 410,000 | +144,000 | 1.40 | 2.33 | +0.94 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,335,437 | 1,473,173 | +137,736 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 260,099 | 395,340 | +135,241 | 0.38 | 0.79 | +0.41 | buy |
| Soleus Capital Management, L.P. | 155,000 | 290,000 | +135,000 | 0.28 | 0.62 | +0.35 | buy |
| BlackRock, Inc. | 4,456,423 | 4,586,514 | +130,091 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 555,117 | 671,692 | +116,575 | 1.55 | 2.00 | +0.45 | buy |
| Nantahala Capital Management, LLC | 0 | 109,449 | +109,449 | 0.00 | 0.27 | +0.27 | buy |
| Rosalind Advisors, Inc. | 192,974 | 300,000 | +107,026 | 2.43 | 4.27 | +1.84 | buy |
| Avidity Partners Management LP | 1,499,942 | 1,600,899 | +100,957 | 7.82 | 14.68 | +6.86 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 541,034 | 638,346 | +97,312 | 2.88 | 3.72 | +0.84 | buy |
| Ikarian Capital, LLC | 155,000 | 249,473 | +94,473 | 1.33 | 2.03 | +0.70 | buy |
| FIRST TRUST ADVISORS LP | 0 | 75,539 | +75,539 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 450,296 | 525,518 | +75,222 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 63,720 | +63,720 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 175,253 | 238,772 | +63,519 | 0.00 | 0.01 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 63,019 | +63,019 | 0.00 | 0.51 | +0.51 | buy |
| SummitTX Capital, L.P. | 27,256 | 86,618 | +59,362 | 0.03 | 0.15 | +0.11 | buy |
| MARSHALL WACE, LLP | 0 | 56,377 | +56,377 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,475,293 | 1,523,409 | +48,116 | 0.09 | 0.13 | +0.04 | buy |
| Cubist Systematic Strategies, LLC | 0 | 43,067 | +43,067 | 0.00 | 0.02 | +0.02 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 56,255 | 94,479 | +38,224 | 0.04 | 0.10 | +0.05 | buy |
| DEUTSCHE BANK AG\ | 37,979 | 72,703 | +34,724 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,109 | 47,986 | +32,877 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,667 | 92,535 | +24,868 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 468,102 | 491,339 | +23,237 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 20,850 | +20,850 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 10,328 | 26,040 | +15,712 | 0.10 | 0.26 | +0.16 | buy |
| AlphaQuest LLC | 0 | 13,600 | +13,600 | 0.00 | 0.04 | +0.04 | buy |
| Brevan Howard Capital Management LP | 0 | 13,224 | +13,224 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 146,663 | 159,592 | +12,929 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 12,437 | +12,437 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 10,500 | 22,615 | +12,115 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 10,172 | +10,172 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 3,856,261 | 3,865,802 | +9,541 | 0.01 | 0.01 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,185 | +9,185 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 7,298 | +7,298 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 7,055 | +7,055 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 6,995 | +6,995 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 6,932 | +6,932 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 24,723 | 31,324 | +6,601 | 0.01 | 0.01 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 6,132 | +6,132 | 0.00 | 0.07 | +0.07 | buy |
| IEQ CAPITAL, LLC | 9,309 | 15,273 | +5,964 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 38,479 | 44,120 | +5,641 | 0.06 | 0.10 | +0.04 | buy |
| Russell Investments Group, Ltd. | 478 | 6,119 | +5,641 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 17,500 | 23,000 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 5,487 | +5,487 | 0.00 | 0.00 | +0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 0 | 5,485 | +5,485 | 0.00 | 0.00 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 5,227 | +5,227 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 29,231 | 34,379 | +5,148 | 0.00 | 0.00 | +0.00 | buy |
| iA Global Asset Management Inc. | 44,400 | 48,660 | +4,260 | 0.02 | 0.03 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,456 | 16,356 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 12,879 | 15,472 | +2,593 | 0.00 | 0.01 | +0.00 | buy |
| Point72 (DIFC) Ltd | 9,239 | 10,972 | +1,733 | 0.02 | 0.03 | +0.01 | buy |
| SG Americas Securities, LLC | 9,271 | 10,872 | +1,601 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 34,655 | 36,255 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 80,100 | 81,300 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Strengthening Families & Communities, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 3,548 | 4,294 | +746 | 0.03 | 0.05 | +0.02 | buy |
| CWM, LLC | 6,193 | 6,865 | +672 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 626 | +626 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 36 | 603 | +567 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 0 | 444 | +444 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 8,043 | 8,281 | +238 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 12,204 | 12,391 | +187 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 300 | 451 | +151 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 403 | 513 | +110 | 0.00 | 0.00 | +0.00 | buy |
| PRIVATE TRUST CO NA | 0 | 71 | +71 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Rise Advisors, LLC | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 7 | +7 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 5 | 12 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,768 | 38,771 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,945 | 2,948 | +3 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| TANG CAPITAL MANAGEMENT LLC | 87,500 | 87,500 | 0 | 0.11 | 0.14 | +0.02 | hold |
| JANUS HENDERSON GROUP PLC | 18,500 | 18,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 135 | 135 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ensign Peak Advisors, Inc | 396,479 | 396,479 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Parkside Financial Bank & Trust | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RTW INVESTMENTS, LP | 1,701,216 | 1,701,216 | 0 | 0.63 | 0.84 | +0.21 | hold |
| BNP Paribas Asset Management Holding S.A. | 381 | 381 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 33,589 | 33,589 | 0 | 0.01 | 0.01 | +0.00 | hold |
| J.Safra Asset Management Corp | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Cormorant Asset Management, LP | 625,000 | 625,000 | 0 | 1.21 | 1.74 | +0.53 | hold |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.23 | 0.27 | +0.05 | hold |
| EverSource Wealth Advisors, LLC | 273 | 273 | 0 | 0.00 | 0.00 | +0.00 | hold |
| KLP KAPITALFORVALTNING AS | 8,100 | 8,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 39 | 39 | 0 | 0.00 | 0.00 | +0.00 | hold |