| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 5,906,511 | 6,577,281 | +670,770 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 6,371,669 | 6,371,669 | 0 | 41.84 | 44.78 | +2.94 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,898,894 | 5,512,779 | +3,613,885 | 0.01 | 0.04 | +0.03 | buy |
| BlackRock, Inc. | 4,456,423 | 4,586,514 | +130,091 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,856,261 | 3,865,802 | +9,541 | 0.01 | 0.01 | +0.00 | buy |
| TCG Crossover Management, LLC | 3,670,206 | 3,670,206 | 0 | 10.90 | 7.27 | -3.63 | hold |
| BRAIDWELL LP | 3,283,317 | 3,283,317 | 0 | 2.92 | 3.92 | +1.00 | hold |
| Foresite Capital Management VI LLC | 2,221,474 | 2,221,474 | 0 | 32.47 | 34.57 | +2.10 | hold |
| ALLIANCEBERNSTEIN L.P. | 2,164,214 | 2,138,119 | -26,095 | 0.02 | 0.03 | +0.01 | sell |
| UBS Group AG | 2,229,245 | 2,126,270 | -102,975 | 0.01 | 0.02 | +0.00 | sell |
| STATE STREET CORP | 2,165,753 | 2,046,667 | -119,086 | 0.00 | 0.00 | +0.00 | sell |
| Kynam Capital Management, LP | 2,457,667 | 2,005,205 | -452,462 | 6.88 | 6.01 | -0.87 | sell |
| ORBIMED ADVISORS LLC | 1,877,850 | 1,726,850 | -151,000 | 1.23 | 1.67 | +0.44 | sell |
| RTW INVESTMENTS, LP | 1,701,216 | 1,701,216 | 0 | 0.63 | 0.84 | +0.21 | hold |
| Avidity Partners Management LP | 1,499,942 | 1,600,899 | +100,957 | 7.82 | 14.68 | +6.86 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,013,690 | 1,588,758 | -424,932 | 0.01 | 0.01 | +0.00 | sell |
| Point72 Asset Management, L.P. | 1,475,293 | 1,523,409 | +48,116 | 0.09 | 0.13 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,335,437 | 1,473,173 | +137,736 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,486,839 | 1,469,303 | -17,536 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,187,101 | 1,366,871 | +179,770 | 0.00 | 0.01 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,354,383 | 1,318,567 | -35,816 | 0.04 | 0.05 | +0.02 | sell |
| ACORN CAPITAL ADVISORS, LLC | 1,131,501 | 1,131,501 | 0 | 19.24 | 23.14 | +3.89 | hold |
| Polar Capital Holdings Plc | 1,098,662 | 1,098,662 | 0 | 0.15 | 0.21 | +0.06 | hold |
| Candriam S.C.A. | 763,580 | 1,037,892 | +274,312 | 0.11 | 0.22 | +0.10 | buy |
| Foresite Capital Management V, LLC | 1,004,050 | 1,004,050 | 0 | 32.34 | 37.19 | +4.85 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 856,597 | 780,302 | -76,295 | 0.00 | 0.01 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,736,769 | 748,345 | -988,424 | 0.00 | 0.00 | -0.00 | sell |
| MANGROVE PARTNERS IM, LLC | 555,117 | 671,692 | +116,575 | 1.55 | 2.00 | +0.45 | buy |
| MORGAN STANLEY | 1,868,148 | 642,414 | -1,225,734 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 541,034 | 638,346 | +97,312 | 2.88 | 3.72 | +0.84 | buy |
| Cormorant Asset Management, LP | 625,000 | 625,000 | 0 | 1.21 | 1.74 | +0.53 | hold |
| Clearbridge Investments, LLC | 0 | 613,852 | +613,852 | 0.00 | 0.02 | +0.02 | buy |
| Saturn V Capital Management LP | 586,647 | 579,895 | -6,752 | 6.18 | 5.12 | -1.06 | sell |
| Woodline Partners LP | 629,357 | 571,478 | -57,879 | 0.09 | 0.11 | +0.02 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 450,296 | 525,518 | +75,222 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 512,201 | 503,526 | -8,675 | 0.19 | 0.29 | +0.10 | sell |
| NORTHERN TRUST CORP | 468,102 | 491,339 | +23,237 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 259,211 | 452,351 | +193,140 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 266,000 | 410,000 | +144,000 | 1.40 | 2.33 | +0.94 | buy |
| Ensign Peak Advisors, Inc | 396,479 | 396,479 | 0 | 0.02 | 0.03 | +0.01 | hold |
| CenterBook Partners LP | 260,099 | 395,340 | +135,241 | 0.38 | 0.79 | +0.41 | buy |
| Rosalind Advisors, Inc. | 192,974 | 300,000 | +107,026 | 2.43 | 4.27 | +1.84 | buy |
| Soleus Capital Management, L.P. | 155,000 | 290,000 | +135,000 | 0.28 | 0.62 | +0.35 | buy |
| ArrowMark Colorado Holdings LLC | 293,006 | 257,230 | -35,776 | 0.14 | 0.19 | +0.06 | sell |
| MILLENNIUM MANAGEMENT LLC | 959,968 | 253,176 | -706,792 | 0.02 | 0.01 | -0.01 | sell |
| Ikarian Capital, LLC | 155,000 | 249,473 | +94,473 | 1.33 | 2.03 | +0.70 | buy |
| ADAR1 Capital Management, LLC | 523,216 | 248,917 | -274,299 | 2.21 | 0.99 | -1.22 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 249,664 | 247,749 | -1,915 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 175,253 | 238,772 | +63,519 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 54,094 | 227,879 | +173,785 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 25,573 | 208,012 | +182,439 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 0 | 175,000 | +175,000 | 0.00 | 0.32 | +0.32 | buy |
| Bank of New York Mellon Corp | 146,663 | 159,592 | +12,929 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 157,874 | +157,874 | 0.00 | 0.54 | +0.54 | buy |
| BARCLAYS PLC | 346,500 | 153,955 | -192,545 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 203,872 | 151,176 | -52,696 | 0.00 | 0.00 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 264,039 | 145,334 | -118,705 | 0.01 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 138,782 | 136,978 | -1,804 | 0.00 | 0.00 | +0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 113,032 | 112,273 | -759 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 153,872 | 110,918 | -42,954 | 0.00 | 0.00 | +0.00 | sell |
| Nantahala Capital Management, LLC | 0 | 109,449 | +109,449 | 0.00 | 0.27 | +0.27 | buy |
| AMERIPRISE FINANCIAL INC | 110,456 | 107,921 | -2,535 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 56,255 | 94,479 | +38,224 | 0.04 | 0.10 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 67,667 | 92,535 | +24,868 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 87,500 | 87,500 | 0 | 0.11 | 0.14 | +0.02 | hold |
| SummitTX Capital, L.P. | 27,256 | 86,618 | +59,362 | 0.03 | 0.15 | +0.11 | buy |
| Swiss National Bank | 80,100 | 81,300 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 82,424 | 80,758 | -1,666 | 0.00 | 0.00 | +0.00 | sell |
| FIRST TRUST ADVISORS LP | 0 | 75,539 | +75,539 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 37,979 | 72,703 | +34,724 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 63,720 | +63,720 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 63,019 | +63,019 | 0.00 | 0.51 | +0.51 | buy |
| Rafferty Asset Management, LLC | 80,228 | 61,684 | -18,544 | 0.01 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 0 | 56,377 | +56,377 | 0.00 | 0.00 | +0.00 | buy |
| iA Global Asset Management Inc. | 44,400 | 48,660 | +4,260 | 0.02 | 0.03 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,109 | 47,986 | +32,877 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 38,479 | 44,120 | +5,641 | 0.06 | 0.10 | +0.04 | buy |
| Legal & General Group Plc | 44,354 | 43,238 | -1,116 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 0 | 43,067 | +43,067 | 0.00 | 0.02 | +0.02 | buy |
| PDT Partners, LLC | 72,143 | 39,967 | -32,176 | 0.11 | 0.10 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 44,328 | 39,918 | -4,410 | 0.00 | 0.00 | +0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,768 | 38,771 | +3 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 41,069 | 37,514 | -3,555 | 0.01 | 0.01 | +0.00 | sell |
| CITIGROUP INC | 50,129 | 36,371 | -13,758 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 34,655 | 36,255 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 29,231 | 34,379 | +5,148 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 33,589 | 33,589 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Cinctive Capital Management LP | 84,856 | 32,558 | -52,298 | 0.12 | 0.07 | -0.06 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 24,723 | 31,324 | +6,601 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 46,081 | 30,225 | -15,856 | 0.01 | 0.01 | -0.01 | sell |
| TEMA ETFS LLC | 46,081 | 30,225 | -15,856 | 0.32 | 0.10 | -0.22 | sell |
| WESBANCO BANK INC | 27,000 | 27,000 | 0 | 0.02 | 0.03 | +0.01 | hold |
| HighVista Strategies LLC | 10,328 | 26,040 | +15,712 | 0.10 | 0.26 | +0.16 | buy |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.23 | 0.27 | +0.05 | hold |
| Handelsbanken Fonder AB | 17,500 | 23,000 | +5,500 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 10,500 | 22,615 | +12,115 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 20,850 | +20,850 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 18,500 | 18,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 17,796 | 17,796 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 13,456 | 16,356 | +2,900 | 0.00 | 0.00 | +0.00 | buy |