| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Decheng Capital LLC | 5,478,810 | 6,371,669 | +892,859 | 48.96 | 39.20 | -9.77 | buy |
| VANGUARD GROUP INC | 5,081,352 | 5,861,082 | +779,730 | 0.00 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 3,570,927 | 4,061,130 | +490,203 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 3,670,206 | 3,670,206 | 0 | 11.73 | 10.29 | -1.45 | hold |
| BRAIDWELL LP | 3,170,875 | 3,283,317 | +112,442 | 3.39 | 2.79 | -0.60 | buy |
| Kynam Capital Management, LP | 1,770,805 | 2,519,705 | +748,900 | 5.18 | 4.77 | -0.41 | buy |
| FMR LLC | 145,606 | 2,433,593 | +2,287,987 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 1,700,653 | 1,923,584 | +222,931 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 510,219 | 1,910,470 | +1,400,251 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,124,905 | 1,817,887 | +692,982 | 0.01 | 0.02 | +0.00 | buy |
| RTW INVESTMENTS, LP | 1,344,074 | 1,701,216 | +357,142 | 0.73 | 0.74 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,526,534 | 1,485,843 | -40,691 | 0.03 | 0.02 | -0.00 | sell |
| MARSHALL WACE, LLP | 7,700 | 1,458,072 | +1,450,372 | 0.00 | 0.05 | +0.05 | buy |
| ORBIMED ADVISORS LLC | 691,114 | 1,431,114 | +740,000 | 0.48 | 0.85 | +0.38 | buy |
| FRANKLIN RESOURCES INC | 1,230,193 | 1,275,891 | +45,698 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 321,363 | 1,169,253 | +847,890 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,078,527 | 1,156,670 | +78,143 | 0.00 | 0.00 | -0.00 | buy |
| Avidity Partners Management LP | 1,656,000 | 1,097,800 | -558,200 | 3.19 | 3.14 | -0.05 | sell |
| UBS Group AG | 86,534 | 1,013,891 | +927,357 | 0.00 | 0.01 | +0.01 | buy |
| Polar Capital Holdings Plc | 967,055 | 967,055 | 0 | 0.17 | 0.16 | -0.02 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 591,407 | 945,194 | +353,787 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 850,695 | 851,593 | +898 | 0.48 | 0.46 | -0.01 | buy |
| GOLDMAN SACHS GROUP INC | 649,574 | 818,667 | +169,093 | 0.00 | 0.00 | -0.00 | buy |
| Cormorant Asset Management, LP | 975,000 | 775,000 | -200,000 | 1.95 | 1.22 | -0.73 | sell |
| Frazier Life Sciences Management, L.P. | 770,000 | 770,000 | 0 | 1.16 | 0.92 | -0.25 | hold |
| MORGAN STANLEY | 234,871 | 725,227 | +490,356 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 700,000 | 700,000 | 0 | 0.39 | 0.28 | -0.10 | hold |
| Foresite Capital Management V, LLC | 692,550 | 692,550 | 0 | 18.16 | 16.53 | -1.63 | hold |
| Pictet Asset Management Holding SA | 0 | 674,607 | +674,607 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 605,898 | 628,885 | +22,987 | 0.19 | 0.12 | -0.07 | buy |
| Saturn V Capital Management LP | 520,119 | 593,262 | +73,143 | 7.01 | 6.66 | -0.35 | buy |
| TimesSquare Capital Management, LLC | 437,069 | 546,904 | +109,835 | 0.25 | 0.23 | -0.02 | buy |
| ABG-WTT Global Life Science Capital Partners GP Ltd | 495,526 | 495,526 | 0 | 92.93 | 32.51 | -60.42 | hold |
| NORTHERN TRUST CORP | 381,441 | 433,860 | +52,419 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 379,664 | 427,760 | +48,096 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 733,695 | 419,450 | -314,245 | 0.59 | 0.34 | -0.26 | sell |
| Soleus Capital Management, L.P. | 340,585 | 328,585 | -12,000 | 1.07 | 0.71 | -0.36 | sell |
| Point72 Asset Management, L.P. | 746,063 | 308,259 | -437,804 | 0.10 | 0.02 | -0.07 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 279,945 | 257,157 | -22,788 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 0 | 249,001 | +249,001 | 0.00 | 0.01 | +0.01 | buy |
| CenterBook Partners LP | 309,296 | 236,108 | -73,188 | 0.72 | 0.40 | -0.31 | sell |
| ArrowMark Colorado Holdings LLC | 230,390 | 224,582 | -5,808 | 0.11 | 0.09 | -0.02 | sell |
| Walleye Capital LLC | 0 | 224,580 | +224,580 | 0.00 | 0.06 | +0.06 | buy |
| ADAR1 Capital Management, LLC | 143,104 | 215,750 | +72,646 | 0.91 | 1.28 | +0.37 | buy |
| BANK OF AMERICA CORP /DE/ | 170,892 | 209,518 | +38,626 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 200,000 | -200,000 | 0.03 | 0.01 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 199,983 | 197,937 | -2,046 | 0.06 | 0.05 | -0.02 | sell |
| Ally Bridge Group (NY) LLC | 263,266 | 174,048 | -89,218 | 5.32 | 4.28 | -1.04 | sell |
| JPMORGAN CHASE & CO | 31,071 | 168,866 | +137,795 | 0.00 | 0.00 | +0.00 | buy |
| Yu Fan | 163,456 | 163,456 | 0 | 18.99 | 2.41 | -16.57 | hold |
| Maven Securities LTD | 0 | 140,000 | +140,000 | 0.00 | 0.65 | +0.65 | buy |
| Bank of New York Mellon Corp | 144,926 | 135,567 | -9,359 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 21,122 | 125,902 | +104,780 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 90,520 | 101,257 | +10,737 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.45 | +0.45 | buy |
| Crestline Management, LP | 7,890 | 95,439 | +87,549 | 0.02 | 0.10 | +0.08 | buy |
| Corebridge Financial, Inc. | 135,629 | 93,189 | -42,440 | 0.03 | 0.01 | -0.01 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 83,000 | 83,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Swiss National Bank | 32,600 | 79,600 | +47,000 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 70,836 | 79,184 | +8,348 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 78,595 | 78,721 | +126 | 0.01 | 0.01 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 73,149 | 76,522 | +3,373 | 0.00 | 0.00 | -0.00 | buy |
| CITIGROUP INC | 35,206 | 71,636 | +36,430 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 67,558 | 69,016 | +1,458 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 195,951 | 61,362 | -134,589 | 0.01 | 0.00 | -0.01 | sell |
| Ensign Peak Advisors, Inc | 60,565 | 60,565 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALPS ADVISORS INC | 53,859 | 54,690 | +831 | 0.01 | 0.01 | -0.00 | buy |
| iA Global Asset Management Inc. | 0 | 45,890 | +45,890 | 0.00 | 0.02 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 0 | 45,000 | +45,000 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 25,389 | 38,978 | +13,589 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 18,005 | 38,768 | +20,763 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,993 | 37,669 | +24,676 | 0.00 | 0.00 | +0.00 | buy |
| Monashee Investment Management LLC | 0 | 36,872 | +36,872 | 0.00 | 0.15 | +0.15 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 22,052 | 30,197 | +8,145 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 29,054 | 30,080 | +1,026 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 24,397 | 29,262 | +4,865 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 27,132 | 29,026 | +1,894 | 0.01 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 19,431 | 28,234 | +8,803 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 15,407 | 27,069 | +11,662 | 0.00 | 0.00 | +0.00 | buy |
| Sicart Associates LLC | 25,000 | 25,000 | 0 | 0.33 | 0.26 | -0.07 | hold |
| Cinctive Capital Management LP | 0 | 22,608 | +22,608 | 0.00 | 0.03 | +0.03 | buy |
| HighVista Strategies LLC | 15,734 | 22,305 | +6,571 | 0.20 | 0.24 | +0.03 | buy |
| AMERIPRISE FINANCIAL INC | 12,895 | 21,946 | +9,051 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 19,996 | +19,996 | 0.00 | 0.05 | +0.05 | buy |
| M&T BANK CORP | 16,758 | 16,891 | +133 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 16,787 | +16,787 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 8,962 | 16,561 | +7,599 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 15,857 | 15,515 | -342 | 0.02 | 0.02 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 0 | 14,340 | +14,340 | 0.00 | 0.04 | +0.04 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 15,003 | 14,163 | -840 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,996 | 13,996 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| Handelsbanken Fonder AB | 0 | 13,300 | +13,300 | 0.00 | 0.00 | +0.00 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 11,024 | 12,834 | +1,810 | 0.01 | 0.01 | -0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 0 | 11,927 | +11,927 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 11,853 | +11,853 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 10,907 | +10,907 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 11,571 | 10,893 | -678 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 324 | 8,865 | +8,541 | 0.00 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 7,512 | 8,329 | +817 | 0.01 | 0.01 | -0.00 | buy |