| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Decheng Capital LLC | 5,478,810 | 6,371,669 | +892,859 | 48.96 | 39.20 | -9.77 | buy |
| Kynam Capital Management, LP | 1,770,805 | 2,519,705 | +748,900 | 5.18 | 4.77 | -0.41 | buy |
| ORBIMED ADVISORS LLC | 691,114 | 1,431,114 | +740,000 | 0.48 | 0.85 | +0.38 | buy |
| RTW INVESTMENTS, LP | 1,344,074 | 1,701,216 | +357,142 | 0.73 | 0.74 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 591,407 | 945,194 | +353,787 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 3,170,875 | 3,283,317 | +112,442 | 3.39 | 2.79 | -0.60 | buy |
| TimesSquare Capital Management, LLC | 437,069 | 546,904 | +109,835 | 0.25 | 100.00 | +99.75 | buy |
| Crestline Management, LP | 7,890 | 95,439 | +87,549 | 0.02 | 0.09 | +0.08 | buy |
| Saturn V Capital Management LP | 520,119 | 593,262 | +73,143 | 7.01 | 6.66 | -0.35 | buy |
| ADAR1 Capital Management, LLC | 143,104 | 215,750 | +72,646 | 0.91 | 1.28 | +0.37 | buy |
| Corebridge Financial, Inc. | 135,629 | 93,189 | +42,440 | 0.03 | 0.02 | 0.00 | sell |
| JANUS HENDERSON GROUP PLC | 1,526,534 | 1,485,843 | +40,691 | 0.03 | 0.02 | 0.00 | sell |
| Woodline Partners LP | 605,898 | 628,885 | +22,987 | 0.19 | 0.12 | -0.07 | buy |
| TD ASSET MANAGEMENT INC | 70,836 | 79,184 | +8,348 | 0.00 | 0.00 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 22,052 | 30,197 | +8,145 | 0.00 | 0.00 | 0.00 | buy |
| HighVista Strategies LLC | 15,734 | 22,305 | +6,571 | 0.20 | 0.24 | +0.03 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 11,024 | 12,834 | +1,810 | 0.03 | 0.03 | 0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 850,695 | 851,593 | +898 | 0.48 | 0.46 | -0.02 | buy |
| ALPS ADVISORS INC | 53,859 | 54,690 | +831 | 0.01 | 0.01 | -0.00 | buy |
| NEOS Investment Management LLC | 7,512 | 8,329 | +817 | 0.01 | 0.01 | -0.00 | buy |
| PROFUND ADVISORS LLC | 15,857 | 15,515 | +342 | 0.02 | 0.02 | 0.00 | sell |
| Rafferty Asset Management, LLC | 78,595 | 78,721 | +126 | 0.01 | 0.01 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,648 | 2,463 | -185 | 0.05 | 0.03 | -0.02 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 199,983 | 197,937 | -2,046 | 0.06 | 0.05 | -0.02 | sell |
| ArrowMark Colorado Holdings LLC | 230,390 | 224,582 | -5,808 | 0.11 | 0.09 | -0.02 | sell |
| Soleus Capital Management, L.P. | 340,585 | 328,585 | -12,000 | 1.07 | 0.71 | -0.36 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 279,945 | 257,157 | -22,788 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 309,296 | 236,108 | -73,188 | 0.72 | 0.40 | -0.31 | sell |
| Ally Bridge Group (NY) LLC | 263,266 | 174,048 | -89,218 | 5.32 | 4.28 | -1.04 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 400,000 | 200,000 | -200,000 | 0.03 | 0.01 | -0.02 | sell |
| Cormorant Asset Management, LP | 975,000 | 775,000 | -200,000 | 1.95 | 1.22 | -0.73 | sell |
| PERCEPTIVE ADVISORS LLC | 733,695 | 419,450 | -314,245 | 0.59 | 0.33 | -0.25 | sell |
| Avidity Partners Management LP | 1,656,000 | 1,097,800 | -558,200 | 3.19 | 3.14 | -0.05 | sell |