| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 6,577,281 | 6,539,482 | -37,799 | 0.00 | 0.00 | -0.00 | sell |
| Decheng Capital LLC | 6,371,669 | 6,371,669 | 0 | 44.78 | 35.59 | -9.19 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 5,512,779 | 5,999,790 | +487,011 | 0.04 | 0.04 | +0.00 | buy |
| BlackRock, Inc. | 4,586,514 | 4,843,242 | +256,728 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 3,865,802 | 4,298,173 | +432,371 | 0.01 | 0.01 | +0.00 | buy |
| TCG Crossover Management, LLC | 3,670,206 | 3,670,206 | 0 | 7.27 | 5.04 | -2.23 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,588,758 | 3,443,144 | +1,854,386 | 0.01 | 0.02 | +0.01 | buy |
| STATE STREET CORP | 2,046,667 | 2,996,695 | +950,028 | 0.00 | 0.00 | +0.00 | buy |
| Foresite Capital Management VI LLC | 2,221,474 | 2,221,474 | 0 | 34.57 | 27.88 | -6.69 | hold |
| RTW INVESTMENTS, LP | 1,701,216 | 2,012,127 | +310,911 | 0.84 | 0.84 | -0.01 | buy |
| UBS Group AG | 2,126,270 | 1,923,746 | -202,524 | 0.02 | 0.02 | -0.00 | sell |
| BRAIDWELL LP | 3,283,317 | 1,870,571 | -1,412,746 | 3.92 | 2.48 | -1.44 | sell |
| ALLIANCEBERNSTEIN L.P. | 2,138,119 | 1,613,425 | -524,694 | 0.03 | 0.02 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 1,469,303 | 1,561,574 | +92,271 | 0.01 | 0.02 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 1,726,850 | 1,516,550 | -210,300 | 1.67 | 1.29 | -0.38 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,473,173 | 1,511,533 | +38,360 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 1,600,899 | 1,472,699 | -128,200 | 14.68 | 17.64 | +2.96 | sell |
| Pictet Asset Management Holding SA | 1,318,567 | 1,349,527 | +30,960 | 0.05 | 0.05 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,366,871 | 1,324,603 | -42,268 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 748,345 | 1,190,053 | +441,708 | 0.00 | 0.00 | +0.00 | buy |
| ACORN CAPITAL ADVISORS, LLC | 1,131,501 | 1,131,501 | 0 | 23.14 | 15.92 | -7.22 | hold |
| Polar Capital Holdings Plc | 1,098,662 | 1,098,662 | 0 | 0.21 | 0.21 | -0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 780,302 | 1,090,894 | +310,592 | 0.01 | 0.01 | +0.00 | buy |
| Foresite Capital Management V, LLC | 1,004,050 | 1,004,050 | 0 | 37.19 | 25.36 | -11.83 | hold |
| Kynam Capital Management, LP | 2,005,205 | 945,830 | -1,059,375 | 6.01 | 2.56 | -3.46 | sell |
| Candriam S.C.A. | 1,037,892 | 797,615 | -240,277 | 0.22 | 0.17 | -0.05 | sell |
| EcoR1 Capital, LLC | 0 | 772,000 | +772,000 | 0.00 | 1.46 | +1.46 | buy |
| Clearbridge Investments, LLC | 613,852 | 705,014 | +91,162 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 238,772 | 681,186 | +442,414 | 0.01 | 0.02 | +0.01 | buy |
| JPMORGAN CHASE & CO | 227,879 | 586,829 | +358,950 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 642,414 | 545,019 | -97,395 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 525,518 | 542,695 | +17,177 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 396,479 | 530,758 | +134,279 | 0.03 | 0.04 | +0.01 | buy |
| Woodline Partners LP | 571,478 | 492,500 | -78,978 | 0.11 | 0.08 | -0.03 | sell |
| NORTHERN TRUST CORP | 491,339 | 481,940 | -9,399 | 0.00 | 0.00 | +0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 452,351 | 461,132 | +8,781 | 0.00 | 0.00 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 503,526 | 426,019 | -77,507 | 0.29 | 0.27 | -0.02 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 422,592 | +422,592 | 0.00 | 0.01 | +0.01 | buy |
| Opaleye Management Inc. | 410,000 | 410,000 | 0 | 2.33 | 2.25 | -0.09 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 638,346 | 361,158 | -277,188 | 3.72 | 2.17 | -1.55 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 312,445 | +312,445 | 0.00 | 0.20 | +0.20 | buy |
| Eversept Partners, LP | 0 | 308,466 | +308,466 | 0.00 | 0.72 | +0.72 | buy |
| Caption Management, LLC | 0 | 306,846 | +306,846 | 0.00 | 0.56 | +0.56 | buy |
| Rosalind Advisors, Inc. | 300,000 | 300,000 | 0 | 4.27 | 4.54 | +0.27 | hold |
| JENNISON ASSOCIATES LLC | 0 | 282,506 | +282,506 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 145,334 | 281,059 | +135,725 | 0.00 | 0.01 | +0.00 | buy |
| MARSHALL WACE, LLP | 56,377 | 261,110 | +204,733 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 248,917 | 258,139 | +9,222 | 0.99 | 0.80 | -0.19 | buy |
| ArrowMark Colorado Holdings LLC | 257,230 | 245,832 | -11,398 | 0.19 | 0.22 | +0.03 | sell |
| AMERIPRISE FINANCIAL INC | 107,921 | 240,477 | +132,556 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 247,749 | 201,918 | -45,831 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 0 | 200,000 | +200,000 | 0.00 | 0.55 | +0.55 | buy |
| Ikarian Capital, LLC | 249,473 | 199,473 | -50,000 | 2.03 | 1.07 | -0.96 | sell |
| BARCLAYS PLC | 153,955 | 187,510 | +33,555 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 151,176 | 186,448 | +35,272 | 0.00 | 0.01 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 75,539 | 181,798 | +106,259 | 0.00 | 0.01 | +0.00 | buy |
| Soleus Capital Management, L.P. | 290,000 | 170,000 | -120,000 | 0.62 | 0.30 | -0.32 | sell |
| PFM Health Sciences, LP | 157,874 | 163,967 | +6,093 | 0.54 | 0.69 | +0.15 | buy |
| Bank of New York Mellon Corp | 159,592 | 155,156 | -4,436 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 1,523,409 | 151,363 | -1,372,046 | 0.13 | 0.01 | -0.12 | sell |
| DEUTSCHE BANK AG\ | 72,703 | 150,188 | +77,485 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 6,119 | 143,346 | +137,227 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 136,978 | 134,692 | -2,286 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 110,918 | 128,478 | +17,560 | 0.00 | 0.00 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 0 | 125,636 | +125,636 | 0.00 | 0.02 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 92,535 | 124,544 | +32,009 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 112,273 | 112,349 | +76 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 109,449 | 109,449 | 0 | 0.27 | 0.27 | -0.00 | hold |
| Rafferty Asset Management, LLC | 61,684 | 106,052 | +44,368 | 0.01 | 0.02 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 11,675 | 96,103 | +84,428 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 253,176 | 91,454 | -161,722 | 0.01 | 0.00 | -0.01 | sell |
| Swiss National Bank | 81,300 | 84,400 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 80,758 | 70,601 | -10,157 | 0.00 | 0.00 | -0.00 | sell |
| CenterBook Partners LP | 395,340 | 69,224 | -326,116 | 0.79 | 0.14 | -0.65 | sell |
| ALPS ADVISORS INC | 37,514 | 66,038 | +28,524 | 0.01 | 0.02 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 36,255 | 62,552 | +26,297 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 94,479 | 59,400 | -35,079 | 0.10 | 0.06 | -0.03 | sell |
| BNP Paribas Asset Management Holding S.A. | 381 | 58,118 | +57,737 | 0.00 | 0.00 | +0.00 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 63,720 | 55,151 | -8,569 | 0.00 | 0.00 | -0.00 | sell |
| SECTOR GAMMA AS | 0 | 52,039 | +52,039 | 0.00 | 0.49 | +0.49 | buy |
| SummitTX Capital, L.P. | 86,618 | 49,928 | -36,690 | 0.15 | 0.06 | -0.08 | sell |
| Legal & General Group Plc | 43,238 | 45,147 | +1,909 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 47,986 | 43,721 | -4,265 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 39,918 | 43,127 | +3,209 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 38,771 | 41,658 | +2,887 | 0.00 | 0.00 | +0.00 | buy |
| AMI ASSET MANAGEMENT CORP | 44,120 | 41,209 | -2,911 | 0.10 | 0.10 | -0.00 | sell |
| PDT Partners, LLC | 39,967 | 39,967 | 0 | 0.10 | 0.11 | +0.01 | hold |
| PROFUND ADVISORS LLC | 13,751 | 39,319 | +25,568 | 0.02 | 0.05 | +0.03 | buy |
| AlphaQuest LLC | 13,600 | 38,894 | +25,294 | 0.04 | 0.09 | +0.05 | buy |
| Invesco Ltd. | 34,379 | 38,140 | +3,761 | 0.00 | 0.00 | -0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 5,227 | 37,834 | +32,607 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 32,558 | 37,171 | +4,613 | 0.07 | 0.09 | +0.02 | buy |
| NEOS Investment Management LLC | 30,225 | 36,597 | +6,372 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 30,225 | 36,057 | +5,832 | 0.10 | 0.12 | +0.02 | buy |
| Sivik Global Healthcare LLC | 0 | 35,000 | +35,000 | 0.00 | 0.71 | +0.71 | buy |
| XTX Topco Ltd | 0 | 33,710 | +33,710 | 0.00 | 0.04 | +0.04 | buy |
| MetLife Investment Management, LLC | 33,589 | 32,348 | -1,241 | 0.01 | 0.01 | +0.00 | sell |
| Lynx1 Capital Management LP | 0 | 31,591 | +31,591 | 0.00 | 0.27 | +0.27 | buy |
| HighVista Strategies LLC | 26,040 | 29,325 | +3,285 | 0.26 | 0.31 | +0.06 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 31,324 | 27,753 | -3,571 | 0.01 | 0.01 | -0.00 | sell |