| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,588,758 | 3,443,144 | +1,854,386 | 0.01 | 0.02 | +0.01 | buy |
| RTW INVESTMENTS, LP | 1,701,216 | 2,012,127 | +310,911 | 0.84 | 0.84 | -0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 145,334 | 281,059 | +135,725 | 0.00 | 0.01 | +0.00 | buy |
| Clearbridge Investments, LLC | 613,852 | 705,014 | +91,162 | 0.02 | 0.02 | +0.00 | buy |
| Rafferty Asset Management, LLC | 61,684 | 106,052 | +44,368 | 0.01 | 0.02 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 151,176 | 186,448 | +35,272 | 0.00 | 0.01 | +0.00 | buy |
| ALPS ADVISORS INC | 37,514 | 66,038 | +28,524 | 0.01 | 0.02 | 0.00 | buy |
| PROFUND ADVISORS LLC | 13,751 | 39,319 | +25,568 | 0.02 | 0.05 | 0.00 | buy |
| AlphaQuest LLC | 13,600 | 38,894 | +25,294 | 0.04 | 0.10 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 248,917 | 258,139 | +9,222 | 0.99 | 0.80 | -0.19 | buy |
| NEOS Investment Management LLC | 30,225 | 36,597 | +6,372 | 0.01 | 0.01 | -0.00 | buy |
| PFM Health Sciences, LP | 157,874 | 163,967 | +6,093 | 0.49 | 0.68 | +0.19 | buy |
| TEMA ETFS LLC | 30,225 | 36,057 | +5,832 | 0.10 | 0.12 | +0.02 | buy |
| Cinctive Capital Management LP | 32,558 | 37,171 | +4,613 | 0.07 | 0.09 | +0.02 | buy |
| HighVista Strategies LLC | 26,040 | 29,325 | +3,285 | 0.26 | 0.31 | +0.06 | buy |
| Virtus Investment Advisers, LLC | 4,294 | 6,497 | +2,203 | 0.05 | 0.07 | +0.02 | buy |
| J.Safra Asset Management Corp | 11 | 72 | +61 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,640 | 1,585 | -55 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 13,365 | 13,145 | -220 | 0.04 | 0.04 | -0.00 | sell |
| Voleon Capital Management LP | 10,172 | 9,699 | -473 | 0.01 | 0.01 | -0.00 | sell |
| AMI ASSET MANAGEMENT CORP | 44,120 | 41,209 | -2,911 | 0.10 | 0.10 | -0.00 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 63,720 | 55,151 | -8,569 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 257,230 | 245,832 | -11,398 | 0.19 | 0.22 | +0.03 | sell |
| SummitTX Capital, L.P. | 86,618 | 49,928 | -36,690 | 0.14 | 0.06 | -0.08 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 247,749 | 201,918 | -45,831 | 0.00 | 0.00 | -0.00 | sell |
| Ikarian Capital, LLC | 249,473 | 199,473 | -50,000 | 2.03 | 1.07 | -0.96 | sell |
| TimesSquare Capital Management, LLC | 503,526 | 426,019 | -77,507 | 100.00 | 0.27 | -99.73 | sell |
| Soleus Capital Management, L.P. | 290,000 | 170,000 | -120,000 | 0.62 | 0.30 | -0.32 | sell |
| Avidity Partners Management LP | 1,600,899 | 1,472,699 | -128,200 | 14.68 | 17.64 | +2.96 | sell |
| ORBIMED ADVISORS LLC | 1,726,850 | 1,516,550 | -210,300 | 1.67 | 1.29 | -0.38 | sell |
| Candriam S.C.A. | 1,037,892 | 797,615 | -240,277 | 0.22 | 0.17 | -0.05 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 638,346 | 361,158 | -277,188 | 3.72 | 2.17 | -1.55 | sell |
| CenterBook Partners LP | 395,340 | 69,224 | -326,116 | 0.79 | 0.14 | -0.65 | sell |
| Kynam Capital Management, LP | 2,005,205 | 945,830 | -1,059,375 | 6.01 | 2.56 | -3.46 | sell |
| BRAIDWELL LP | 3,283,317 | 1,870,571 | -1,412,746 | 3.92 | 2.48 | -1.44 | sell |