| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vida Ventures Advisors, LLC | 0 | 4,523,924 | +4,523,924 | 0.00 | 62.43 | +62.43 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 3,163,868 | +3,163,868 | 0.00 | 6.32 | +6.32 | buy |
| RTW INVESTMENTS, LP | 0 | 1,852,711 | +1,852,711 | 0.00 | 0.68 | +0.68 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 1,462,337 | +1,462,337 | 0.00 | 0.63 | +0.63 | buy |
| JENNISON ASSOCIATES LLC | 0 | 1,398,659 | +1,398,659 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 929,634 | +929,634 | 0.00 | 0.00 | +0.00 | buy |
| Insight Holdings Group, LLC | 0 | 912,915 | +912,915 | 0.00 | 0.63 | +0.63 | buy |
| Commodore Capital LP | 0 | 912,189 | +912,189 | 0.00 | 1.52 | +1.52 | buy |
| JPMORGAN CHASE & CO | 0 | 844,465 | +844,465 | 0.00 | 0.00 | +0.00 | buy |
| Novo Holdings A/S | 0 | 700,000 | +700,000 | 0.00 | 1.20 | +1.20 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 695,094 | +695,094 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 606,500 | +606,500 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 601,436 | +601,436 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 575,000 | +575,000 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 0 | 523,743 | +523,743 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 1.31 | +1.31 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 475,827 | +475,827 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 0 | 475,000 | +475,000 | 0.00 | 0.14 | +0.14 | buy |
| FRANKLIN RESOURCES INC | 0 | 460,561 | +460,561 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 450,000 | +450,000 | 0.00 | 0.28 | +0.28 | buy |
| Cormorant Asset Management, LP | 0 | 440,000 | +440,000 | 0.00 | 0.48 | +0.48 | buy |
| Woodline Partners LP | 0 | 392,928 | +392,928 | 0.00 | 0.09 | +0.09 | buy |
| VANGUARD GROUP INC | 0 | 264,215 | +264,215 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 202,333 | +202,333 | 0.00 | 0.18 | +0.18 | buy |
| Artal Group S.A. | 0 | 200,000 | +200,000 | 0.00 | 0.13 | +0.13 | buy |
| Rock Springs Capital Management LP | 0 | 178,963 | +178,963 | 0.00 | 0.11 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 172,236 | +172,236 | 0.00 | 0.00 | +0.00 | buy |
| Cutter Capital Management, LP | 0 | 166,514 | +166,514 | 0.00 | 1.59 | +1.59 | buy |
| MARSHALL WACE, LLP | 0 | 155,755 | +155,755 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 150,000 | +150,000 | 0.00 | 0.07 | +0.07 | buy |
| GREAT POINT PARTNERS LLC | 0 | 150,000 | +150,000 | 0.00 | 0.58 | +0.58 | buy |
| Casdin Capital, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.28 | +0.28 | buy |
| Walleye Capital LLC | 0 | 150,000 | +150,000 | 0.00 | 0.04 | +0.04 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 105,900 | +105,900 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 104,814 | +104,814 | 0.00 | 0.07 | +0.07 | buy |
| Blackstone Inc. | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 88,423 | +88,423 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 84,880 | +84,880 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 75,865 | +75,865 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 70,000 | +70,000 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 0 | 69,237 | +69,237 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 65,000 | +65,000 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 0 | 59,666 | +59,666 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 50,400 | +50,400 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 0 | 50,000 | +50,000 | 0.00 | 0.04 | +0.04 | buy |
| BARCLAYS PLC | 0 | 43,094 | +43,094 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 41,000 | +41,000 | 0.00 | 0.27 | +0.27 | buy |
| Polar Asset Management Partners Inc. | 0 | 40,000 | +40,000 | 0.00 | 0.03 | +0.03 | buy |
| NORGES BANK | 0 | 40,000 | +40,000 | 0.00 | 0.00 | +0.00 | buy |
| Ghisallo Capital Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.11 | +0.11 | buy |
| MORGAN STANLEY | 0 | 39,931 | +39,931 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 37,500 | +37,500 | 0.00 | 0.03 | +0.03 | buy |
| JANE STREET GROUP, LLC | 0 | 37,041 | +37,041 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 36,583 | +36,583 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 28,793 | +28,793 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 28,494 | +28,494 | 0.00 | 0.00 | +0.00 | buy |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 0 | 25,000 | +25,000 | 0.00 | 0.08 | +0.08 | buy |
| UBS Group AG | 0 | 24,898 | +24,898 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 20,900 | +20,900 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 20,842 | +20,842 | 0.00 | 0.00 | +0.00 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 16,810 | +16,810 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 16,721 | +16,721 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 0 | 15,846 | +15,846 | 0.00 | 2.24 | +2.24 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 13,016 | +13,016 | 0.00 | 0.00 | +0.00 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 12,614 | +12,614 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 11,906 | +11,906 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 11,500 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 11,435 | +11,435 | 0.00 | 0.03 | +0.03 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 10,133 | +10,133 | 0.00 | 0.07 | +0.07 | buy |
| Sofinnova Investments, Inc. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| Greenland Capital Management LP | 0 | 10,000 | +10,000 | 0.00 | 0.04 | +0.04 | buy |
| Legal & General Group Plc | 0 | 9,585 | +9,585 | 0.00 | 0.00 | +0.00 | buy |
| Diametric Capital, LP | 0 | 9,300 | +9,300 | 0.00 | 0.13 | +0.13 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 8,492 | +8,492 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 7,500 | +7,500 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 7,000 | +7,000 | 0.00 | 0.07 | +0.07 | buy |
| Cubist Systematic Strategies, LLC | 0 | 2,775 | +2,775 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 0 | 950 | +950 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 766 | +766 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 183 | +183 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 63 | +63 | 0.00 | 0.00 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |