| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 4,126,119 | 4,126,119 | 0 | 2.00 | 1.68 | -0.32 | hold |
| Bain Capital Life Sciences Investors, LLC | 3,110,000 | 3,110,000 | 0 | 2.24 | 2.42 | +0.18 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,000,000 | 2,000,000 | 0 | 0.24 | 0.20 | -0.04 | hold |
| AIGH Capital Management LLC | 1,500,000 | 2,000,000 | +500,000 | 4.17 | 3.53 | -0.63 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,762,617 | 1,555,287 | -207,330 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 980,869 | 1,125,321 | +144,452 | 0.02 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 593,369 | 1,005,508 | +412,139 | 0.00 | 0.01 | +0.00 | buy |
| Insight Holdings Group, LLC | 989,054 | 989,054 | 0 | 0.70 | 0.60 | -0.10 | hold |
| MORGAN STANLEY | 1,002,495 | 977,289 | -25,206 | 0.00 | 0.00 | -0.00 | sell |
| BlackRock, Inc. | 544,539 | 877,078 | +332,539 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 845,143 | 845,325 | +182 | 0.03 | 0.03 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 518,512 | 721,581 | +203,069 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 666,666 | 644,421 | -22,245 | 5.35 | 3.52 | -1.83 | sell |
| MBB PUBLIC MARKETS I LLC | 614,477 | 614,477 | 0 | 0.60 | 0.63 | +0.03 | hold |
| MARSHALL WACE, LLP | 135,600 | 605,512 | +469,912 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 238,828 | 577,600 | +338,772 | 0.00 | 0.01 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,666,666 | 500,000 | -1,166,666 | 0.02 | 0.01 | -0.02 | sell |
| UBS Group AG | 202,187 | 449,750 | +247,563 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 266,402 | 423,826 | +157,424 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 252,151 | 412,032 | +159,881 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 177,899 | 367,492 | +189,593 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 63,616 | 333,692 | +270,076 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 32,184 | 222,929 | +190,745 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 133,530 | 212,910 | +79,380 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,426 | 211,088 | +85,662 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 200,000 | 200,000 | 0 | 0.12 | 0.09 | -0.04 | hold |
| Invesco Ltd. | 0 | 186,674 | +186,674 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 205,267 | 181,615 | -23,652 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 192,339 | 173,106 | -19,233 | 0.03 | 0.02 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 222,796 | 169,082 | -53,714 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 174,900 | 149,900 | -25,000 | 0.03 | 0.03 | -0.01 | sell |
| Squarepoint Ops LLC | 138,868 | 146,978 | +8,110 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 91,300 | 138,300 | +47,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 164,668 | 136,375 | -28,293 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,530 | 134,530 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STIFEL FINANCIAL CORP | 125,790 | 130,524 | +4,734 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 114,841 | +114,841 | 0.00 | 0.02 | +0.02 | buy |
| WELLS FARGO & COMPANY/MN | 74,949 | 114,399 | +39,450 | 0.00 | 0.00 | +0.00 | buy |
| WESBANCO BANK INC | 0 | 110,300 | +110,300 | 0.00 | 0.03 | +0.03 | buy |
| Kera Capital Partners, Inc. | 132,603 | 108,083 | -24,520 | 0.13 | 0.11 | -0.02 | sell |
| JANE STREET GROUP, LLC | 182,093 | 104,214 | -77,879 | 0.00 | 0.00 | -0.00 | sell |
| 683 Capital Management, LLC | 114,900 | 85,000 | -29,900 | 0.09 | 0.07 | -0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 78,413 | 78,419 | +6 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 51,572 | 78,042 | +26,470 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 88,553 | 71,059 | -17,494 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 275,446 | 58,126 | -217,320 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 55,728 | +55,728 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 53,543 | +53,543 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 46,367 | 53,235 | +6,868 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 80,299 | 52,762 | -27,537 | 0.01 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 49,011 | +49,011 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 68,140 | 44,045 | -24,095 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 12,297 | 42,260 | +29,963 | 0.00 | 0.00 | +0.00 | buy |
| Peapod Lane Capital LLC | 183,820 | 40,404 | -143,416 | 1.47 | 0.28 | -1.19 | sell |
| Quadrature Capital Ltd | 57,369 | 38,411 | -18,958 | 0.01 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 38,196 | +38,196 | 0.00 | 0.00 | +0.00 | buy |
| Banque Cantonale Vaudoise | 0 | 30,532 | +30,532 | 0.00 | 0.01 | +0.01 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 27,846 | +27,846 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 27,014 | +27,014 | 0.00 | 0.02 | +0.02 | buy |
| Jefferies Financial Group Inc. | 32,001 | 23,920 | -8,081 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 57,428 | 22,428 | -35,000 | 0.04 | 0.01 | -0.03 | sell |
| FEDERATED HERMES, INC. | 20,705 | 20,705 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Schonfeld Strategic Advisors LLC | 28,872 | 20,154 | -8,718 | 0.00 | 0.00 | +0.00 | sell |
| Phoenix Wealth Advisors | 12,300 | 19,800 | +7,500 | 0.04 | 0.07 | +0.02 | buy |
| CAXTON CORP | 18,773 | 18,773 | 0 | 4.12 | 4.03 | -0.10 | hold |
| Vanguard Personalized Indexing Management, LLC | 19,048 | 18,747 | -301 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 108,534 | 16,599 | -91,935 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 0 | 16,161 | +16,161 | 0.00 | 0.01 | +0.01 | buy |
| RAYMOND JAMES FINANCIAL INC | 25,082 | 16,082 | -9,000 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 0 | 16,067 | +16,067 | 0.00 | 0.04 | +0.04 | buy |
| OMERS ADMINISTRATION Corp | 34,800 | 14,800 | -20,000 | 0.00 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 13,900 | +13,900 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 11,965 | +11,965 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 12,609 | 11,928 | -681 | 0.00 | 0.00 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 11,089 | +11,089 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 7,137 | 10,138 | +3,001 | 0.01 | 0.01 | +0.00 | buy |
| GSB Wealth Management, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.02 | +0.02 | buy |
| CAPITAL ADVISORS INC/OK | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 6,976 | 6,811 | -165 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 3,998 | +3,998 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 3,917 | 3,917 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 5,073 | 3,128 | -1,945 | 0.00 | 0.00 | -0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 2,128 | 2,980 | +852 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2,124 | +2,124 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 1,629 | +1,629 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,313 | 1,313 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 860 | 977 | +117 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 822 | +822 | 0.00 | 0.00 | +0.00 | buy |
| Accent Capital Management, LLC | 0 | 545 | +545 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 301 | 301 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TFC Financial Management, Inc. | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Fourth Dimension Wealth, LLC | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 163 | 135 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Fortitude Family Office, LLC | 0 | 126 | +126 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 54 | +54 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HEIGHTS CAPITAL MANAGEMENT, INC | 271,822 | 0 | -271,822 | 0.97 | 0.00 | -0.97 | sell |