| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vida Ventures Advisors, LLC | 4,523,924 | 4,523,924 | 0 | 62.43 | 37.11 | -25.32 | hold |
| Bain Capital Life Sciences Investors, LLC | 3,163,868 | 3,368,370 | +204,502 | 6.32 | 2.77 | -3.54 | buy |
| JPMORGAN CHASE & CO | 844,465 | 2,061,257 | +1,216,792 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,462,337 | 1,983,000 | +520,663 | 0.63 | 0.25 | -0.38 | buy |
| RTW INVESTMENTS, LP | 1,852,711 | 1,852,711 | 0 | 0.68 | 0.22 | -0.46 | hold |
| Novo Holdings A/S | 700,000 | 1,750,000 | +1,050,000 | 1.20 | 0.71 | -0.49 | buy |
| VANGUARD GROUP INC | 264,215 | 1,016,621 | +752,406 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 695,094 | 923,082 | +227,988 | 0.01 | 0.01 | -0.01 | buy |
| Insight Holdings Group, LLC | 912,915 | 912,915 | 0 | 0.63 | 0.24 | -0.40 | hold |
| FRANKLIN RESOURCES INC | 460,561 | 823,039 | +362,478 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 601,436 | 713,400 | +111,964 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 929,634 | 669,557 | -260,077 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 150,000 | 575,000 | +425,000 | 0.28 | 0.33 | +0.05 | buy |
| GREAT POINT PARTNERS LLC | 150,000 | 499,152 | +349,152 | 0.58 | 0.72 | +0.14 | buy |
| EcoR1 Capital, LLC | 450,000 | 450,000 | 0 | 0.28 | 0.10 | -0.18 | hold |
| MBB PUBLIC MARKETS I LLC | 0 | 410,191 | +410,191 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 172,236 | 372,598 | +200,362 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 50,400 | 315,948 | +265,548 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 236,029 | +236,029 | 0.00 | 0.29 | +0.29 | buy |
| CITADEL ADVISORS LLC | 523,743 | 228,137 | -295,606 | 0.01 | 0.00 | -0.01 | sell |
| Artal Group S.A. | 200,000 | 200,000 | 0 | 0.13 | 0.04 | -0.09 | hold |
| Affinity Asset Advisors, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.24 | +0.24 | buy |
| E Fund Management Co., Ltd. | 0 | 189,432 | +189,432 | 0.00 | 0.08 | +0.08 | buy |
| NORGES BANK | 40,000 | 180,593 | +140,593 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 178,963 | 178,963 | 0 | 0.11 | 0.04 | -0.07 | hold |
| Walleye Capital LLC | 150,000 | 156,515 | +6,515 | 0.04 | 0.01 | -0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 20,842 | 156,296 | +135,454 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 150,000 | 150,000 | 0 | 0.07 | 0.03 | -0.04 | hold |
| Woodline Partners LP | 392,928 | 132,900 | -260,028 | 0.09 | 0.01 | -0.08 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 84,880 | 125,077 | +40,197 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 36,583 | 117,991 | +81,408 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 105,900 | 115,365 | +9,465 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,906 | 112,709 | +100,803 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 90,242 | +90,242 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 65,000 | 90,000 | +25,000 | 0.01 | 0.00 | -0.01 | buy |
| Pictet Asset Management Holding SA | 100,000 | 86,115 | -13,885 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 0 | 83,286 | +83,286 | 0.00 | 0.05 | +0.05 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 575,000 | 75,000 | -500,000 | 0.03 | 0.00 | -0.03 | sell |
| Jump Financial, LLC | 0 | 66,960 | +66,960 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 62,290 | +62,290 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 61,303 | +61,303 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 43,094 | 57,749 | +14,655 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 0 | 55,790 | +55,790 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 10,000 | 47,850 | +37,850 | 0.01 | 0.02 | +0.01 | buy |
| Qube Research & Technologies Ltd | 69,237 | 42,424 | -26,813 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 28,793 | 40,490 | +11,697 | 0.00 | 0.00 | -0.00 | buy |
| Polar Asset Management Partners Inc. | 40,000 | 40,000 | 0 | 0.03 | 0.01 | -0.02 | hold |
| Ghisallo Capital Management LLC | 40,000 | 40,000 | 0 | 0.11 | 0.03 | -0.09 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 28,494 | 37,794 | +9,300 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 33,629 | +33,629 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 29,700 | +29,700 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 16,810 | 26,195 | +9,385 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 475,827 | 25,710 | -450,117 | 0.00 | 0.00 | -0.00 | sell |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 25,000 | 25,000 | 0 | 0.08 | 0.02 | -0.06 | hold |
| CAXTON CORP | 15,846 | 22,981 | +7,135 | 2.24 | 0.87 | -1.37 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 12,614 | 21,410 | +8,796 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 20,007 | +20,007 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 16,169 | +16,169 | 0.00 | 0.02 | +0.02 | buy |
| FEDERATED HERMES, INC. | 0 | 16,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 15,055 | +15,055 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 183 | 13,600 | +13,417 | 0.00 | 0.00 | +0.00 | buy |
| GAGNON SECURITIES LLC | 0 | 12,136 | +12,136 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 10,450 | +10,450 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 155,755 | 10,400 | -145,355 | 0.01 | 0.00 | -0.01 | sell |
| DekaBank Deutsche Girozentrale | 7,500 | 7,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 9,585 | 7,389 | -2,196 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 7,000 | 7,000 | 0 | 0.07 | 0.02 | -0.05 | hold |
| VIRTUS ADVISERS, LLC | 0 | 6,269 | +6,269 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 59,666 | 5,176 | -54,490 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 0 | 4,693 | +4,693 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 3,100 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,649 | +1,649 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 582 | +582 | 0.00 | 0.00 | +0.00 | buy |
| Westend Capital Management, LLC | 0 | 445 | +445 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 323 | +323 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 63 | 152 | +89 | 0.00 | 0.00 | -0.00 | buy |
| Washington Trust Advisors, Inc. | 60 | 60 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRUDENTIAL FINANCIAL INC | 11,500 | 0 | -11,500 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 16,721 | 0 | -16,721 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 606,500 | 0 | -606,500 | 0.01 | 0.00 | -0.01 | sell |
| Laurion Capital Management LP | 37,500 | 0 | -37,500 | 0.03 | 0.00 | -0.03 | sell |
| Blackstone Inc. | 100,000 | 0 | -100,000 | 0.01 | 0.00 | -0.01 | sell |
| Hudson Bay Capital Management LP | 50,000 | 0 | -50,000 | 0.01 | 0.00 | -0.01 | sell |
| MACQUARIE GROUP LTD | 950 | 0 | -950 | 0.00 | 0.00 | -0.00 | sell |
| ArrowMark Colorado Holdings LLC | 70,000 | 0 | -70,000 | 0.02 | 0.00 | -0.02 | sell |
| Brevan Howard Capital Management LP | 11,435 | 0 | -11,435 | 0.03 | 0.00 | -0.03 | sell |
| Tower Research Capital LLC (TRC) | 766 | 0 | -766 | 0.00 | 0.00 | -0.00 | sell |
| LMR Partners LLP | 104,814 | 0 | -104,814 | 0.07 | 0.00 | -0.07 | sell |
| Cormorant Asset Management, LP | 440,000 | 0 | -440,000 | 0.48 | 0.00 | -0.48 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 20,000 | 0 | -20,000 | 0.01 | 0.00 | -0.01 | sell |
| JANE STREET GROUP, LLC | 37,041 | 0 | -37,041 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 2,775 | 0 | -2,775 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 20,900 | 0 | -20,900 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 24,898 | 0 | -24,898 | 0.00 | 0.00 | -0.00 | sell |
| Avoro Capital Advisors LLC | 475,000 | 0 | -475,000 | 0.14 | 0.00 | -0.14 | sell |
| Squarepoint Ops LLC | 88,423 | 0 | -88,423 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 10,133 | 0 | -10,133 | 0.07 | 0.00 | -0.07 | sell |
| OSAIC HOLDINGS, INC. | 2,000 | 0 | -2,000 | 0.00 | 0.00 | -0.00 | sell |
| Diametric Capital, LP | 9,300 | 0 | -9,300 | 0.13 | 0.00 | -0.13 | sell |