| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vida Ventures Advisors, LLC | 4,523,924 | 4,523,924 | 0 | 64.02 | 87.24 | +23.22 | hold |
| GILEAD SCIENCES, INC. | 4,126,119 | 4,126,119 | 0 | 0.67 | 0.99 | +0.32 | hold |
| Bain Capital Life Sciences Investors, LLC | 3,368,370 | 3,368,370 | 0 | 0.96 | 1.29 | +0.33 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 579,604 | 1,830,501 | +1,250,897 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,298,449 | 1,312,767 | +14,318 | 0.00 | 0.00 | +0.00 | buy |
| Insight Holdings Group, LLC | 989,054 | 989,054 | 0 | 0.15 | 0.13 | -0.02 | hold |
| FRANKLIN RESOURCES INC | 692,028 | 695,027 | +2,999 | 0.00 | 0.00 | +0.00 | buy |
| MBB PUBLIC MARKETS I LLC | 614,477 | 614,477 | 0 | 0.14 | 0.22 | +0.08 | hold |
| Catalio Capital Management, LP | 586,909 | 586,909 | 0 | 0.28 | 0.38 | +0.10 | hold |
| BlackRock, Inc. | 1,676,268 | 533,467 | -1,142,801 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 238,239 | 452,560 | +214,321 | 0.00 | 0.00 | +0.00 | buy |
| Kera Capital Partners, Inc. | 376,186 | 421,924 | +45,738 | 0.22 | 0.26 | +0.04 | buy |
| Peapod Lane Capital LLC | 396,221 | 396,763 | +542 | 0.86 | 1.22 | +0.36 | buy |
| CITADEL ADVISORS LLC | 993,620 | 325,389 | -668,231 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 563,974 | 287,601 | -276,373 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 90,242 | 252,196 | +161,954 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 68,628 | 144,623 | +75,995 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 191,287 | 142,542 | -48,745 | 0.44 | 0.55 | +0.10 | sell |
| GOLDMAN SACHS GROUP INC | 104,460 | 136,378 | +31,918 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 124,958 | 122,417 | -2,541 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 122,977 | 120,584 | -2,393 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 165,370 | 118,606 | -46,764 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,602 | 118,297 | +79,695 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 71,057 | 100,158 | +29,101 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 80,900 | 94,300 | +13,400 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 374,578 | 91,300 | -283,278 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 87,769 | +87,769 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 136,300 | 62,900 | -73,400 | 0.01 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 24,561 | 62,057 | +37,496 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 55,522 | +55,522 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 191,664 | 51,678 | -139,986 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 81,390 | 50,394 | -30,996 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 36,000 | 44,000 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 42,025 | +42,025 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 39,163 | 38,965 | -198 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 67,546 | 36,247 | -31,299 | 0.01 | 0.01 | -0.00 | sell |
| XTX Topco Ltd | 0 | 34,939 | +34,939 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 29,730 | +29,730 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 39,502 | 27,855 | -11,647 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 0 | 26,243 | +26,243 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 22,981 | 22,981 | 0 | 0.87 | 0.72 | -0.16 | hold |
| HRT FINANCIAL LP | 0 | 20,171 | +20,171 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 15,275 | 19,122 | +3,847 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 0 | 17,036 | +17,036 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,153 | 15,832 | -3,321 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 0 | 14,051 | +14,051 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 13,552 | 12,392 | -1,160 | 0.00 | 0.00 | +0.00 | sell |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 12,039 | +12,039 | 0.00 | 0.01 | +0.01 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 12,000 | +12,000 | 0.00 | 0.01 | +0.01 | buy |
| IEQ CAPITAL, LLC | 12,275 | 11,068 | -1,207 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 8,173 | 10,906 | +2,733 | 0.00 | 0.00 | +0.00 | buy |
| Phoenix Wealth Advisors | 0 | 10,500 | +10,500 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 10,375 | +10,375 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 8,659 | 8,680 | +21 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 2,393 | 8,180 | +5,787 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 5,482 | 7,965 | +2,483 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 7,500 | 7,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 46,381 | 4,431 | -41,950 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 0 | 3,917 | +3,917 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 2,084 | 1,700 | -384 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 1,445 | 1,670 | +225 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 6,214 | 1,313 | -4,901 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 1,070 | 1,070 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 259 | 301 | +42 | 0.00 | 0.00 | +0.00 | buy |
| Fourth Dimension Wealth, LLC | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| True Wealth Design, LLC | 154 | 220 | +66 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 140 | 160 | +20 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 515 | 145 | -370 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 2 | 16 | +14 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 1,098 | 0 | -1,098 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,649 | 0 | -1,649 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,932 | 0 | -1,932 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 21,945 | 0 | -21,945 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 30,010 | 0 | -30,010 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 31,614 | 0 | -31,614 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 186 | 0 | -186 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 32,126 | 0 | -32,126 | 0.00 | 0.00 | -0.00 | sell |
| Novo Holdings A/S | 1,850,000 | 0 | -1,850,000 | 0.27 | 0.00 | -0.27 | sell |
| Bank of New York Mellon Corp | 48,784 | 0 | -48,784 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 177,670 | 0 | -177,670 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,912 | 0 | -14,912 | 0.00 | 0.00 | -0.00 | sell |
| Physician Wealth Advisors, Inc. | 420 | 0 | -420 | 0.00 | 0.00 | -0.00 | sell |
| Nuveen, LLC | 47,508 | 0 | -47,508 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 12,624 | 0 | -12,624 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 1,827 | 0 | -1,827 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 3,385 | 0 | -3,385 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 24,660 | 0 | -24,660 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 2,769 | 0 | -2,769 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,500 | 0 | -4,500 | 0.00 | 0.00 | -0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 81 | 0 | -81 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 3,100 | 0 | -3,100 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 37,828 | 0 | -37,828 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 582 | 0 | -582 | 0.00 | 0.00 | -0.00 | sell |