| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GILEAD SCIENCES, INC. | 4,126,119 | 4,126,119 | 0 | 1.68 | 2.23 | +0.55 | hold |
| BlackRock, Inc. | 877,078 | 3,134,807 | +2,257,729 | 0.00 | 0.00 | +0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 3,110,000 | 2,885,000 | -225,000 | 2.42 | 1.53 | -0.89 | sell |
| AIGH Capital Management LLC | 2,000,000 | 2,795,797 | +795,797 | 3.53 | 2.26 | -1.28 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,000,000 | 2,000,000 | 0 | 0.20 | 0.19 | -0.02 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,555,287 | 1,186,023 | -369,264 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 423,826 | 1,049,430 | +625,604 | 0.00 | 0.00 | +0.00 | buy |
| Insight Holdings Group, LLC | 989,054 | 989,054 | 0 | 0.60 | 0.67 | +0.07 | hold |
| MORGAN STANLEY | 977,289 | 982,307 | +5,018 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 138,300 | 982,233 | +843,933 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 644,421 | 883,198 | +238,777 | 3.52 | 4.12 | +0.60 | buy |
| Woodline Partners LP | 845,325 | 845,325 | 0 | 0.03 | 0.02 | -0.00 | hold |
| MILLENNIUM MANAGEMENT LLC | 1,005,508 | 639,780 | -365,728 | 0.01 | 0.00 | -0.00 | sell |
| MBB PUBLIC MARKETS I LLC | 614,477 | 614,477 | 0 | 0.63 | 0.59 | -0.04 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 500,000 | 500,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| D. E. Shaw & Co., Inc. | 721,581 | 469,346 | -252,235 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 114,399 | 373,009 | +258,610 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 449,750 | 365,574 | -84,176 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 212,910 | 335,230 | +122,320 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 367,492 | 333,899 | -33,593 | 0.00 | 0.00 | -0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 319,666 | +319,666 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 211,088 | 319,666 | +108,578 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 78,042 | 315,354 | +237,312 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 412,032 | 310,632 | -101,400 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 55,728 | 265,405 | +209,677 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 38,196 | 245,587 | +207,391 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 114,841 | 242,387 | +127,546 | 0.02 | 0.04 | +0.02 | buy |
| Nuveen, LLC | 0 | 233,743 | +233,743 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 200,000 | 200,000 | 0 | 0.09 | 0.06 | -0.02 | hold |
| Simplify Asset Management Inc. | 173,106 | 182,603 | +9,497 | 0.02 | 0.02 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 577,600 | 155,800 | -421,800 | 0.01 | 0.00 | -0.01 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 149,900 | 149,900 | 0 | 0.03 | 0.02 | -0.00 | hold |
| CITADEL ADVISORS LLC | 58,126 | 147,627 | +89,501 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 169,082 | 145,682 | -23,400 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 130,524 | 139,965 | +9,441 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 333,692 | 123,646 | -210,046 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 136,375 | 117,844 | -18,531 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 117,442 | +117,442 | 0.00 | 0.00 | +0.00 | buy |
| WESBANCO BANK INC | 110,300 | 110,300 | 0 | 0.03 | 0.02 | -0.00 | hold |
| Jump Financial, LLC | 52,762 | 101,352 | +48,590 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 100,281 | +100,281 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 6,811 | 96,051 | +89,240 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 1,125,321 | 96,048 | -1,029,273 | 0.02 | 0.00 | -0.02 | sell |
| Susquehanna Portfolio Strategies, LLC | 27,846 | 88,845 | +60,999 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 146,978 | 82,867 | -64,111 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 134,530 | 82,207 | -52,323 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 78,419 | 78,419 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN CENTURY COMPANIES INC | 53,235 | 69,351 | +16,116 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 53,543 | 68,640 | +15,097 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 186,674 | 55,807 | -130,867 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 181,615 | 51,319 | -130,296 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 0 | 50,188 | +50,188 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 45,360 | +45,360 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 3,917 | 44,853 | +40,936 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 41,907 | +41,907 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 13,900 | 40,000 | +26,100 | 0.00 | 0.00 | +0.00 | buy |
| Kera Capital Partners, Inc. | 108,083 | 40,000 | -68,083 | 0.11 | 0.03 | -0.08 | sell |
| Banque Cantonale Vaudoise | 30,532 | 33,444 | +2,912 | 0.01 | 0.00 | -0.01 | buy |
| FEDERATED HERMES, INC. | 20,705 | 30,705 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 25,741 | +25,741 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 25,625 | +25,625 | 0.00 | 0.00 | +0.00 | buy |
| Spark Investment Management LLC | 0 | 25,100 | +25,100 | 0.00 | 0.44 | +0.44 | buy |
| JPMORGAN CHASE & CO | 0 | 22,984 | +22,984 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 22,100 | +22,100 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 21,898 | +21,898 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 822 | 21,287 | +20,465 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 42,260 | 20,858 | -21,402 | 0.00 | 0.00 | -0.00 | sell |
| Phoenix Wealth Advisors | 19,800 | 19,800 | 0 | 0.07 | 0.06 | -0.01 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 19,240 | +19,240 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 18,747 | 17,987 | -760 | 0.00 | 0.00 | -0.00 | sell |
| WINTON GROUP Ltd | 0 | 17,400 | +17,400 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 104,214 | 17,314 | -86,900 | 0.00 | 0.00 | -0.00 | sell |
| Virtu Financial LLC | 0 | 13,577 | +13,577 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 12,376 | +12,376 | 0.00 | 0.00 | +0.00 | buy |
| CAXTON CORP | 18,773 | 12,347 | -6,426 | 4.03 | 5.94 | +1.91 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 11,850 | +11,850 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 11,928 | 11,823 | -105 | 0.00 | 0.00 | -0.00 | sell |
| Samalin Investment Counsel, LLC | 0 | 11,595 | +11,595 | 0.00 | 0.03 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 49,011 | 11,476 | -37,535 | 0.00 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 0 | 11,000 | +11,000 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 10,849 | +10,849 | 0.00 | 0.01 | +0.01 | buy |
| GSB Wealth Management, LLC | 10,000 | 10,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| CAPITAL ADVISORS INC/OK | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 10,138 | 9,676 | -462 | 0.01 | 0.01 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 9,000 | +9,000 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 8,583 | +8,583 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 4,072 | +4,072 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 3,808 | +3,808 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 1,629 | 3,113 | +1,484 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,980 | 2,719 | -261 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,128 | 2,353 | -775 | 0.00 | 0.00 | -0.00 | sell |
| Parallel Advisors, LLC | 0 | 1,694 | +1,694 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 977 | 1,212 | +235 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 0 | 785 | +785 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 578 | +578 | 0.00 | 0.00 | +0.00 | buy |
| Accent Capital Management, LLC | 545 | 545 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 0 | 466 | +466 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 400 | 398 | -2 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 301 | 301 | 0 | 0.00 | 0.00 | -0.00 | hold |