| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Vida Ventures Advisors, LLC | 4,523,924 | 4,523,924 | 0 | 37.11 | 15.96 | -21.15 | hold |
| Bain Capital Life Sciences Investors, LLC | 3,368,370 | 3,368,370 | 0 | 2.77 | 1.71 | -1.06 | hold |
| JPMORGAN CHASE & CO | 2,061,257 | 2,387,352 | +326,095 | 0.00 | 0.00 | -0.00 | buy |
| Novo Holdings A/S | 1,750,000 | 1,850,000 | +100,000 | 0.71 | 0.45 | -0.26 | buy |
| MILLENNIUM MANAGEMENT LLC | 923,082 | 1,253,556 | +330,474 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 1,016,621 | 1,006,707 | -9,914 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 823,039 | 936,961 | +113,922 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,983,000 | 918,892 | -1,064,108 | 0.25 | 0.07 | -0.18 | sell |
| Insight Holdings Group, LLC | 912,915 | 912,915 | 0 | 0.24 | 0.19 | -0.04 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 669,557 | 628,222 | -41,335 | 0.00 | 0.00 | -0.00 | sell |
| MBB PUBLIC MARKETS I LLC | 410,191 | 614,477 | +204,286 | 0.06 | 0.25 | +0.19 | buy |
| EcoR1 Capital, LLC | 450,000 | 450,000 | 0 | 0.10 | 0.08 | -0.03 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 372,598 | 443,312 | +70,714 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 315,948 | 326,192 | +10,244 | 0.00 | 0.00 | -0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 236,029 | 248,651 | +12,622 | 0.29 | 0.20 | -0.09 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 713,400 | 235,123 | -478,277 | 0.00 | 0.00 | -0.00 | sell |
| Integral Health Asset Management, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.12 | +0.12 | buy |
| E Fund Management Co., Ltd. | 189,432 | 189,432 | 0 | 0.08 | 0.05 | -0.03 | hold |
| Rock Springs Capital Management LP | 178,963 | 178,963 | 0 | 0.04 | 0.03 | -0.01 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,077 | 166,635 | +41,558 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 112,709 | 153,787 | +41,078 | 0.00 | 0.00 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 150,000 | 150,000 | 0 | 0.03 | 0.02 | -0.01 | hold |
| CITADEL ADVISORS LLC | 228,137 | 137,739 | -90,398 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 40,490 | 133,937 | +93,447 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 156,296 | 122,854 | -33,442 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 117,991 | 122,777 | +4,786 | 0.00 | 0.00 | -0.00 | buy |
| Affinity Asset Advisors, LLC | 200,000 | 119,900 | -80,100 | 0.24 | 0.09 | -0.15 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 115,365 | 101,900 | -13,465 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 90,242 | 90,242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 62,290 | 79,803 | +17,513 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 57,749 | 70,167 | +12,418 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 0 | 68,958 | +68,958 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 83,286 | 52,792 | -30,494 | 0.05 | 0.02 | -0.03 | sell |
| Hudson Bay Capital Management LP | 0 | 52,035 | +52,035 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 90,000 | 45,000 | -45,000 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 44,626 | +44,626 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 55,790 | 43,266 | -12,524 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 132,900 | 42,477 | -90,423 | 0.01 | 0.00 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 0 | 41,984 | +41,984 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 180,593 | 40,000 | -140,593 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 0 | 39,570 | +39,570 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,794 | 37,794 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Point72 Asset Management, L.P. | 0 | 34,482 | +34,482 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 33,308 | +33,308 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 33,629 | 33,056 | -573 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 10,400 | 32,223 | +21,823 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 16,000 | 32,000 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 25,710 | 30,010 | +4,300 | 0.00 | 0.00 | -0.00 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 27,580 | +27,580 | 0.00 | 0.02 | +0.02 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,200 | 27,197 | +25,997 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 26,195 | 26,195 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 25,000 | 25,000 | 0 | 0.02 | 0.01 | -0.01 | hold |
| CAXTON CORP | 22,981 | 22,981 | 0 | 0.87 | 0.47 | -0.41 | hold |
| SECTORAL ASSET MANAGEMENT INC | 7,000 | 22,900 | +15,900 | 0.02 | 0.07 | +0.04 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 21,395 | +21,395 | 0.00 | 0.01 | +0.01 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 19,869 | +19,869 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 20,007 | 19,767 | -240 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 16,900 | +16,900 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,176 | 13,494 | +8,318 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 12,849 | +12,849 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 11,028 | +11,028 | 0.00 | 0.00 | +0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 10,179 | +10,179 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 9,298 | +9,298 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 9,057 | 9,001 | -56 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 7,500 | 7,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FMR LLC | 0 | 6,692 | +6,692 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 6,269 | 6,381 | +112 | 0.02 | 0.01 | -0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 13,600 | 4,500 | -9,100 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 3,100 | 3,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 7,389 | 1,708 | -5,681 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,649 | 1,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 15,055 | 1,220 | -13,835 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 0 | 1,206 | +1,206 | 0.00 | 0.00 | +0.00 | buy |
| Point72 (DIFC) Ltd | 0 | 968 | +968 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 600 | +600 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 582 | 582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 0 | 314 | +314 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 169 | +169 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 152 | 122 | -30 | 0.00 | 0.00 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 60 | 60 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CWM, LLC | 0 | 55 | +55 | 0.00 | 0.00 | 0.00 | buy |
| Allworth Financial LP | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 200,000 | 0 | -200,000 | 0.04 | 0.00 | -0.04 | sell |
| GAGNON SECURITIES LLC | 12,136 | 0 | -12,136 | 0.02 | 0.00 | -0.02 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 75,000 | 0 | -75,000 | 0.00 | 0.00 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 499,152 | 0 | -499,152 | 0.72 | 0.00 | -0.72 | sell |
| Polar Asset Management Partners Inc. | 40,000 | 0 | -40,000 | 0.01 | 0.00 | -0.01 | sell |
| Westend Capital Management, LLC | 445 | 0 | -445 | 0.00 | 0.00 | -0.00 | sell |
| RTW INVESTMENTS, LP | 1,852,711 | 0 | -1,852,711 | 0.22 | 0.00 | -0.22 | sell |
| MetLife Investment Management, LLC | 4,693 | 0 | -4,693 | 0.00 | 0.00 | -0.00 | sell |
| Casdin Capital, LLC | 575,000 | 0 | -575,000 | 0.33 | 0.00 | -0.33 | sell |
| Alpine Global Management, LLC | 16,169 | 0 | -16,169 | 0.02 | 0.00 | -0.02 | sell |
| Swiss National Bank | 29,700 | 0 | -29,700 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 323 | 0 | -323 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 47,850 | 0 | -47,850 | 0.02 | 0.00 | -0.02 | sell |
| Schonfeld Strategic Advisors LLC | 61,303 | 0 | -61,303 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 42,424 | 0 | -42,424 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 156,515 | 0 | -156,515 | 0.01 | 0.00 | -0.01 | sell |
| Ghisallo Capital Management LLC | 40,000 | 0 | -40,000 | 0.03 | 0.00 | -0.03 | sell |