| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JACOBS LEVY EQUITY MANAGEMENT, INC | 19,869 | 461,959 | +442,090 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 1,006,707 | 1,313,232 | +306,525 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 0 | 203,403 | +203,403 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 182,177 | +182,177 | 0.00 | 0.60 | +0.60 | buy |
| BlackRock, Inc. | 1,520,261 | 1,672,493 | +152,232 | 0.00 | 0.00 | -0.00 | buy |
| Integral Health Asset Management, LLC | 200,000 | 350,000 | +150,000 | 0.12 | 0.12 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 443,312 | 539,682 | +96,370 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 122,777 | 190,383 | +67,606 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 16,900 | 80,290 | +63,390 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 133,937 | 195,694 | +61,757 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 122,854 | 181,654 | +58,800 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 326,192 | 379,888 | +53,696 | 0.00 | 0.00 | -0.00 | buy |
| Verition Fund Management LLC | 44,626 | 90,235 | +45,609 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 44,700 | +44,700 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 39,342 | +39,342 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 235,123 | 274,414 | +39,291 | 0.00 | 0.00 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 79,803 | 113,474 | +33,671 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 33,434 | +33,434 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 153,787 | 179,012 | +25,225 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 137,739 | 162,319 | +24,580 | 0.00 | 0.00 | -0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 21,395 | 43,762 | +22,367 | 0.01 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 70,167 | 89,586 | +19,419 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 27,197 | 44,983 | +17,786 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 12,099 | +12,099 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 11,488 | +11,488 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 9,154 | +9,154 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 13,494 | 20,325 | +6,831 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 19,767 | 25,920 | +6,153 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,298 | 14,288 | +4,990 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 169 | 4,600 | +4,431 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 4,171 | +4,171 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 9,001 | 12,811 | +3,810 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 3,765 | +3,765 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 166,635 | 169,780 | +3,145 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 33,056 | 34,912 | +1,856 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,464 | +1,464 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 1,439 | +1,439 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,708 | 2,769 | +1,061 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,220 | 1,932 | +712 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 32 | 233 | +201 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 55 | 229 | +174 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 105 | +105 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,649 | 1,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD ASSET MANAGEMENT INC | 90,242 | 90,242 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 32,000 | 32,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 30,010 | 30,010 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Insight Holdings Group, LLC | 912,915 | 912,915 | 0 | 0.19 | 0.22 | +0.03 | hold |
| NORGES BANK | 40,000 | 40,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Novo Holdings A/S | 1,850,000 | 1,850,000 | 0 | 0.45 | 0.42 | -0.03 | hold |
| CAXTON CORP | 22,981 | 22,981 | 0 | 0.47 | 0.52 | +0.05 | hold |
| Alyeska Investment Group, L.P. | 45,000 | 45,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DekaBank Deutsche Girozentrale | 7,500 | 7,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rock Springs Capital Management LP | 178,963 | 178,963 | 0 | 0.03 | 0.03 | -0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 3,368,370 | 3,368,370 | 0 | 1.71 | 1.48 | -0.23 | hold |
| Vida Ventures Advisors, LLC | 4,523,924 | 4,523,924 | 0 | 15.96 | 11.56 | -4.40 | hold |
| MBB PUBLIC MARKETS I LLC | 614,477 | 614,477 | 0 | 0.25 | 0.27 | +0.02 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,500 | 4,500 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 3,100 | 3,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 582 | 582 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 37,794 | 37,794 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EARNED WEALTH ADVISORS, LLC | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 28 | 0 | -28 | 0.00 | 0.00 | -0.00 | sell |
| Washington Trust Advisors, Inc. | 60 | 0 | -60 | 0.00 | 0.00 | -0.00 | sell |
| COMERICA BANK | 122 | 0 | -122 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 314 | 0 | -314 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 600 | 0 | -600 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,206 | 364 | -842 | 0.00 | 0.00 | -0.00 | sell |
| Point72 (DIFC) Ltd | 968 | 0 | -968 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 43,266 | 39,933 | -3,333 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 6,692 | 1,609 | -5,083 | 0.00 | 0.00 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 6,381 | 0 | -6,381 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 52,792 | 43,949 | -8,843 | 0.02 | 0.01 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 12,849 | 2,742 | -10,107 | 0.00 | 0.00 | -0.00 | sell |
| TWINBEECH CAPITAL LP | 10,179 | 0 | -10,179 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 11,028 | 0 | -11,028 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 68,958 | 52,361 | -16,597 | 0.01 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 32,223 | 15,241 | -16,982 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 22,900 | 0 | -22,900 | 0.07 | 0.00 | -0.07 | sell |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 25,000 | 0 | -25,000 | 0.01 | 0.00 | -0.01 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 26,195 | 0 | -26,195 | 0.00 | 0.00 | -0.00 | sell |
| OCCUDO QUANTITATIVE STRATEGIES LP | 27,580 | 0 | -27,580 | 0.02 | 0.00 | -0.02 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 33,308 | 0 | -33,308 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 34,482 | 0 | -34,482 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 628,222 | 593,688 | -34,534 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 39,570 | 0 | -39,570 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 41,984 | 0 | -41,984 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 42,477 | 0 | -42,477 | 0.00 | 0.00 | -0.00 | sell |
| Hudson Bay Capital Management LP | 52,035 | 0 | -52,035 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 101,900 | 0 | -101,900 | 0.00 | 0.00 | -0.00 | sell |
| Affinity Asset Advisors, LLC | 119,900 | 0 | -119,900 | 0.09 | 0.00 | -0.09 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 248,651 | 118,758 | -129,893 | 0.20 | 0.08 | -0.12 | sell |
| PERCEPTIVE ADVISORS LLC | 150,000 | 0 | -150,000 | 0.02 | 0.00 | -0.02 | sell |
| E Fund Management Co., Ltd. | 189,432 | 0 | -189,432 | 0.05 | 0.00 | -0.05 | sell |
| JPMORGAN CHASE & CO | 2,387,352 | 2,166,437 | -220,915 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 936,961 | 692,028 | -244,933 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 450,000 | 0 | -450,000 | 0.08 | 0.00 | -0.08 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,253,556 | 746,521 | -507,035 | 0.01 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 918,892 | 0 | -918,892 | 0.07 | 0.00 | -0.07 | sell |