| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.24 | +0.24 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,666,666 | +1,666,666 | 0.00 | 0.02 | +0.02 | buy |
| AIGH Capital Management LLC | 0 | 1,500,000 | +1,500,000 | 0.00 | 4.17 | +4.17 | buy |
| MORGAN STANLEY | 0 | 1,002,495 | +1,002,495 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 980,869 | +980,869 | 0.00 | 0.02 | +0.02 | buy |
| Propel Bio Management, LLC | 0 | 666,666 | +666,666 | 0.00 | 5.35 | +5.35 | buy |
| Alyeska Investment Group, L.P. | 0 | 600,000 | +600,000 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 252,212 | 845,143 | +592,931 | 0.01 | 0.03 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 0 | 518,512 | +518,512 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 1,322,625 | 1,781,257 | +458,632 | 0.00 | 0.00 | +0.00 | buy |
| RFG Advisory, LLC | 0 | 445,200 | +445,200 | 0.00 | 0.08 | +0.08 | buy |
| CITADEL ADVISORS LLC | 0 | 275,446 | +275,446 | 0.00 | 0.00 | +0.00 | buy |
| HEIGHTS CAPITAL MANAGEMENT, INC | 0 | 271,822 | +271,822 | 0.00 | 0.97 | +0.97 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,512,199 | 1,762,617 | +250,418 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 34,022 | 252,151 | +218,129 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.12 | +0.12 | buy |
| Monashee Investment Management LLC | 0 | 195,000 | +195,000 | 0.00 | 1.03 | +1.03 | buy |
| Simplify Asset Management Inc. | 0 | 192,339 | +192,339 | 0.00 | 0.03 | +0.03 | buy |
| Maven Securities LTD | 0 | 146,400 | +146,400 | 0.00 | 0.17 | +0.17 | buy |
| Squarepoint Ops LLC | 0 | 138,868 | +138,868 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 135,600 | +135,600 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 114,900 | +114,900 | 0.00 | 0.09 | +0.09 | buy |
| GOLDMAN SACHS GROUP INC | 43,132 | 133,530 | +90,398 | 0.00 | 0.00 | +0.00 | buy |
| Hudson Bay Capital Management LP | 0 | 88,553 | +88,553 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 76,191 | 164,668 | +88,477 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 38,821 | 125,790 | +86,969 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 80,299 | +80,299 | 0.00 | 0.01 | +0.01 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 78,413 | +78,413 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 132,451 | 205,267 | +72,816 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 68,140 | +68,140 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 482,054 | 544,539 | +62,485 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 164,796 | 222,796 | +58,000 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 57,428 | +57,428 | 0.00 | 0.04 | +0.04 | buy |
| Quadrature Capital Ltd | 0 | 57,369 | +57,369 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 18,280 | 74,949 | +56,669 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 157,422 | 202,187 | +44,765 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 551,635 | 593,369 | +41,734 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 202,690 | 238,828 | +36,138 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 34,800 | +34,800 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 103,808 | 134,530 | +30,722 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 28,872 | +28,872 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 36,691 | 63,616 | +26,925 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 25,082 | +25,082 | 0.00 | 0.00 | +0.00 | buy |
| Cambria Investment Management, L.P. | 0 | 17,935 | +17,935 | 0.00 | 0.01 | +0.01 | buy |
| Empowered Funds, LLC | 0 | 17,935 | +17,935 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 16,343 | +16,343 | 0.00 | 0.01 | +0.01 | buy |
| Jefferies Financial Group Inc. | 16,300 | 32,001 | +15,701 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 32,205 | 46,367 | +14,162 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 164,614 | 177,899 | +13,285 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 10,048 | +10,048 | 0.00 | 0.04 | +0.04 | buy |
| CITIGROUP INC | 3,319 | 12,297 | +8,978 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 15,158 | 20,705 | +5,547 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 27,176 | 32,184 | +5,008 | 0.00 | 0.00 | +0.00 | buy |
| Phoenix Wealth Advisors | 10,500 | 12,300 | +1,800 | 0.02 | 0.04 | +0.02 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 1,668 | +1,668 | 0.00 | 0.00 | +0.00 | buy |
| Vermillion & White Wealth Management Group, LLC | 0 | 1,100 | +1,100 | 0.00 | 0.01 | +0.01 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,672 | 2,128 | +456 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| TFC Financial Management, Inc. | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| Vanguard Personalized Indexing Management, LLC | 18,893 | 19,048 | +155 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 26 | +26 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 174,900 | 174,900 | 0 | 0.02 | 0.03 | +0.01 | hold |
| Insight Holdings Group, LLC | 989,054 | 989,054 | 0 | 0.37 | 0.70 | +0.33 | hold |
| DekaBank Deutsche Girozentrale | 7,500 | 7,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Arax Advisory Partners | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Russell Investments Group, Ltd. | 1,313 | 1,313 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MBB PUBLIC MARKETS I LLC | 614,477 | 614,477 | 0 | 0.49 | 0.60 | +0.11 | hold |
| Fourth Dimension Wealth, LLC | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CAPITAL ADVISORS INC/OK | 10,000 | 10,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GILEAD SCIENCES, INC. | 4,126,119 | 4,126,119 | 0 | 1.38 | 2.00 | +0.62 | hold |
| STATE STREET CORP | 91,300 | 91,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 301 | 301 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DEUTSCHE BANK AG\ | 3,917 | 3,917 | 0 | 0.00 | 0.00 | +0.00 | hold |
| IFP Advisors, Inc | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 200 | 163 | -37 | 0.00 | 0.00 | +0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 898 | 860 | -38 | 0.00 | 0.00 | +0.00 | sell |
| Advisory Services Network, LLC | 86 | 0 | -86 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 51,678 | 51,572 | -106 | 0.00 | 0.00 | +0.00 | sell |
| SBI Securities Co., Ltd. | 137 | 22 | -115 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,578 | 125,426 | -152 | 0.00 | 0.00 | +0.00 | sell |
| Wilmington Savings Fund Society, FSB | 253 | 0 | -253 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 7,580 | 7,137 | -443 | 0.00 | 0.01 | +0.00 | sell |
| CWM, LLC | 499 | 0 | -499 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 7,918 | 6,976 | -942 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 6,231 | 5,073 | -1,158 | 0.00 | 0.00 | +0.00 | sell |
| Ethic Inc. | 15,353 | 12,609 | -2,744 | 0.00 | 0.00 | +0.00 | sell |
| CAXTON CORP | 22,981 | 18,773 | -4,208 | 0.60 | 4.12 | +3.52 | sell |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 4,600 | 0 | -4,600 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 278,329 | 266,402 | -11,927 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 12,882 | 0 | -12,882 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 13,542 | 0 | -13,542 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 15,109 | 0 | -15,109 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 198,851 | 182,093 | -16,758 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 19,438 | 0 | -19,438 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 49,107 | 23,282 | -25,825 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 81,300 | 49,400 | -31,900 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 147,712 | 108,534 | -39,178 | 0.00 | 0.00 | +0.00 | sell |
| Peapod Lane Capital LLC | 318,760 | 183,820 | -134,940 | 1.71 | 1.47 | -0.24 | sell |
| Bain Capital Life Sciences Investors, LLC | 3,368,370 | 3,110,000 | -258,370 | 1.34 | 2.24 | +0.90 | sell |
| Kera Capital Partners, Inc. | 421,924 | 132,603 | -289,321 | 0.38 | 0.13 | -0.25 | sell |