| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Alpha Wave Global, LP | 3,707,757 | 3,707,757 | 0 | 10.54 | 1.57 | -8.98 | hold |
| Commodore Capital LP | 2,723,196 | 2,723,196 | 0 | 3.54 | 4.28 | +0.74 | hold |
| BlackRock, Inc. | 666,188 | 2,121,009 | +1,454,821 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,009,893 | 1,609,893 | -400,000 | 0.89 | 0.66 | -0.23 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 385,000 | 1,600,000 | +1,215,000 | 0.01 | 0.06 | +0.05 | buy |
| Vivo Capital, LLC | 1,035,551 | 1,208,858 | +173,307 | 1.94 | 2.91 | +0.98 | buy |
| FRANKLIN RESOURCES INC | 1,101,874 | 1,013,307 | -88,567 | 0.01 | 0.01 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 912,000 | 864,000 | -48,000 | 0.68 | 0.63 | -0.05 | sell |
| Affinity Asset Advisors, LLC | 500,000 | 850,000 | +350,000 | 0.66 | 1.10 | +0.44 | buy |
| Vestal Point Capital, LP | 2,064,075 | 785,000 | -1,279,075 | 1.30 | 0.48 | -0.81 | sell |
| STATE STREET CORP | 199,503 | 685,945 | +486,442 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 292,899 | 678,199 | +385,300 | 0.00 | 0.00 | +0.00 | buy |
| 72 Investment Holdings, LLC | 667,778 | 667,778 | 0 | 30.26 | 35.27 | +5.01 | hold |
| NORTHERN TRUST CORP | 473,403 | 632,701 | +159,298 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 821,982 | 558,320 | -263,662 | 0.01 | 0.01 | -0.00 | sell |
| Point72 Asset Management, L.P. | 503,087 | 502,950 | -137 | 0.02 | 0.02 | +0.00 | sell |
| VR Adviser, LLC | 500,000 | 500,000 | 0 | 0.42 | 0.40 | -0.02 | hold |
| Integral Health Asset Management, LLC | 500,000 | 500,000 | 0 | 0.59 | 0.54 | -0.05 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 486,726 | 487,576 | +850 | 0.08 | 0.07 | -0.01 | buy |
| Parkman Healthcare Partners LLC | 0 | 429,035 | +429,035 | 0.00 | 1.16 | +1.16 | buy |
| Ikarian Capital, LLC | 515,000 | 407,338 | -107,662 | 1.66 | 1.76 | +0.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 371,208 | 358,279 | -12,929 | 0.00 | 0.00 | -0.00 | sell |
| ORBIMED ADVISORS LLC | 167,500 | 257,852 | +90,352 | 0.08 | 0.13 | +0.05 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 257,631 | +257,631 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 104,717 | 236,830 | +132,113 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 176,347 | 225,503 | +49,156 | 0.00 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 13,324 | 190,996 | +177,672 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 88,999 | 182,829 | +93,830 | 0.36 | 0.69 | +0.33 | buy |
| TWO SIGMA INVESTMENTS, LP | 216,099 | 147,299 | -68,800 | 0.00 | 0.00 | -0.00 | sell |
| Eversept Partners, LP | 125,168 | 128,286 | +3,118 | 0.19 | 0.18 | -0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 139,304 | 106,234 | -33,070 | 0.07 | 0.05 | -0.02 | sell |
| ALKEON CAPITAL MANAGEMENT LLC | 227,101 | 102,101 | -125,000 | 0.02 | 0.01 | -0.01 | sell |
| STIFEL FINANCIAL CORP | 86,335 | 85,480 | -855 | 0.00 | 0.00 | +0.00 | sell |
| Sixth Street Partners Management Company, L.P. | 0 | 80,583 | +80,583 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 17,018 | 80,583 | +63,565 | 0.00 | 0.00 | +0.00 | buy |
| AWM Investment Company, Inc. | 170,000 | 80,000 | -90,000 | 0.42 | 0.18 | -0.24 | sell |
| Bank of New York Mellon Corp | 0 | 76,330 | +76,330 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 68,654 | 74,940 | +6,286 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 103,499 | 71,399 | -32,100 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 59,799 | 70,913 | +11,114 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 41,023 | 70,748 | +29,725 | 0.17 | 0.23 | +0.06 | buy |
| Nuveen, LLC | 0 | 62,342 | +62,342 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 58,697 | +58,697 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 60,076 | 55,509 | -4,567 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 52,653 | 50,653 | -2,000 | 0.02 | 0.02 | -0.00 | sell |
| XTX Topco Ltd | 39,841 | 46,601 | +6,760 | 0.02 | 0.02 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 43,800 | 43,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 39,324 | 42,561 | +3,237 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 36,069 | 38,556 | +2,487 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 25,288 | 35,613 | +10,325 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 31,636 | +31,636 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 23,747 | 30,233 | +6,486 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 27,300 | +27,300 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 14,186 | 26,820 | +12,634 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 26,303 | +26,303 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 26,051 | +26,051 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 28,500 | 26,000 | -2,500 | 0.00 | 0.00 | -0.00 | sell |
| BROWN ADVISORY INC | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGEMENT CO | 22,175 | 22,175 | 0 | 0.07 | 0.07 | -0.00 | hold |
| Squarepoint Ops LLC | 29,961 | 21,286 | -8,675 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 9,430 | 20,745 | +11,315 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 25,677 | 19,101 | -6,576 | 0.00 | 0.00 | -0.00 | sell |
| Revisor Wealth Management LLC | 17,130 | 17,130 | 0 | 0.11 | 0.11 | +0.00 | hold |
| SCS Capital Management LLC | 16,840 | 16,840 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MetLife Investment Management, LLC | 0 | 15,644 | +15,644 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 15,239 | +15,239 | 0.00 | 0.09 | +0.09 | buy |
| BANK OF NOVA SCOTIA | 0 | 14,400 | +14,400 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 14,255 | +14,255 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 25,036 | 13,318 | -11,718 | 0.00 | 0.00 | -0.00 | sell |
| Vanguard Personalized Indexing Management, LLC | 15,646 | 12,658 | -2,988 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 12,009 | +12,009 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 11,343 | 11,415 | +72 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 10,904 | +10,904 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 9,200 | +9,200 | 0.00 | 0.00 | +0.00 | buy |
| GK Wealth Management LLC | 0 | 8,565 | +8,565 | 0.00 | 0.14 | +0.14 | buy |
| IEQ CAPITAL, LLC | 23,727 | 7,988 | -15,739 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 0 | 7,908 | +7,908 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 7,725 | +7,725 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 7,698 | +7,698 | 0.00 | 0.06 | +0.06 | buy |
| State of Wyoming | 0 | 7,684 | +7,684 | 0.00 | 0.02 | +0.02 | buy |
| FMR LLC | 6,314 | 6,325 | +11 | 0.00 | 0.00 | -0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 314 | 3,880 | +3,566 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 3,575 | +3,575 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 2,543 | +2,543 | 0.00 | 0.00 | +0.00 | buy |
| WHITTIER TRUST CO OF NEVADA INC | 2,482 | 2,482 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ameritas Investment Partners, Inc. | 0 | 2,377 | +2,377 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 65 | 1,996 | +1,931 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 1,206 | 1,200 | -6 | 0.00 | 0.00 | +0.00 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 1,006 | +1,006 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 1,685 | 685 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 0 | 600 | +600 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 628 | 560 | -68 | 0.00 | 0.00 | +0.00 | sell |
| JONES FINANCIAL COMPANIES LLLP | 533 | 533 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Accent Capital Management, LLC | 275 | 366 | +91 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 361 | +361 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 338 | 338 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Aster Capital Management (DIFC) Ltd | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 4 | 112 | +108 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 654 | 110 | -544 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |