| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GEODE CAPITAL MANAGEMENT, LLC | 68,342 | 125,241 | +56,899 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 1,159,614 | 1,205,447 | +45,833 | 0.09 | 0.08 | -0.01 | buy |
| Granite Investment Partners, LLC | 0 | 27,053 | +27,053 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 16,557 | +16,557 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 18,103 | 23,350 | +5,247 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,258,501 | 1,258,501 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 9,876,576 | 9,876,576 | 0 | 0.19 | 0.22 | +0.03 | hold |
| Alyeska Investment Group, L.P. | 1,159,615 | 1,159,615 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sio Capital Management, LLC | 1,288,461 | 1,288,461 | 0 | 0.22 | 0.21 | -0.01 | hold |
| Opaleye Management Inc. | 18,444 | 18,444 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Crewe Advisors LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Shaolin Capital Management LLC | 171,170 | 171,170 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 80,000 | 80,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| NORTHERN TRUST CORP | 21,598 | 21,598 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TORONTO DOMINION BANK | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 8,146 | 2,202 | -5,944 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 18,618 | 0 | -18,618 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 515,384 | 251,972 | -263,412 | 0.08 | 0.03 | -0.04 | sell |
| Hudson Bay Capital Management LP | 296,369 | 0 | -296,369 | 0.00 | 0.00 | -0.00 | sell |
| ARMISTICE CAPITAL, LLC | 478,000 | 0 | -478,000 | 0.01 | 0.00 | -0.01 | sell |