| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 821,261 | 1,058,501 | +237,240 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 33,078 | +33,078 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 27,000 | +27,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 36,242 | 36,242 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 9,876,576 | 9,876,576 | 0 | 0.48 | 0.55 | +0.07 | hold |
| RTW INVESTMENTS, LP | 209,361 | 209,361 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Opaleye Management Inc. | 110,571 | 110,571 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Affinity Asset Advisors, LLC | 80,000 | 80,000 | 0 | 0.02 | 0.01 | -0.00 | hold |
| TORONTO DOMINION BANK | 25,000 | 25,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 3,474 | 2,084 | -1,390 | 0.00 | 0.00 | -0.00 | sell |
| Shaolin Capital Management LLC | 616,160 | 180,000 | -436,160 | 0.01 | 0.02 | +0.00 | sell |