| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sio Capital Management, LLC | 0 | 1,288,461 | +1,288,461 | 0.00 | 0.22 | +0.22 | buy |
| Alyeska Investment Group, L.P. | 0 | 1,159,615 | +1,159,615 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,159,614 | +1,159,614 | 0.00 | 0.09 | +0.09 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 515,384 | +515,384 | 0.00 | 0.08 | +0.08 | buy |
| ARMISTICE CAPITAL, LLC | 0 | 478,000 | +478,000 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 296,369 | +296,369 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,058,501 | 1,258,501 | +200,000 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 33,078 | 79,451 | +46,373 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 36,242 | 68,342 | +32,100 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 0 | 21,598 | +21,598 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 18,618 | +18,618 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 18,103 | +18,103 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,084 | 8,146 | +6,062 | 0.00 | 0.00 | +0.00 | buy |
| Crewe Advisors LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 9,876,576 | 9,876,576 | 0 | 0.55 | 0.19 | -0.37 | hold |
| Affinity Asset Advisors, LLC | 80,000 | 80,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| TORONTO DOMINION BANK | 25,000 | 25,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Shaolin Capital Management LLC | 180,000 | 171,170 | -8,830 | 0.02 | 0.01 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 27,000 | 0 | -27,000 | 0.00 | 0.00 | -0.00 | sell |
| Opaleye Management Inc. | 110,571 | 18,444 | -92,127 | 0.03 | 0.00 | -0.03 | sell |
| RTW INVESTMENTS, LP | 209,361 | 0 | -209,361 | 0.01 | 0.00 | -0.01 | sell |