| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 1,263,078 | 1,308,051 | +44,973 | 0.01 | 0.01 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,442,707 | 1,297,763 | -144,944 | 1.92 | 1.91 | -0.01 | sell |
| Sanofi | 1,157,926 | 1,157,926 | 0 | 23.17 | 20.54 | -2.63 | hold |
| VIKING GLOBAL INVESTORS LP | 1,437,705 | 1,123,929 | -313,776 | 0.27 | 0.30 | +0.03 | sell |
| HighTower Advisors, LLC | 870,200 | 870,551 | +351 | 0.06 | 0.08 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 32,683 | 841,141 | +808,458 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 798,898 | 825,972 | +27,074 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 254,827 | 697,586 | +442,759 | 0.14 | 0.35 | +0.21 | buy |
| STATE STREET CORP | 550,845 | 640,458 | +89,613 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 384,433 | 400,892 | +16,459 | 0.10 | 0.12 | +0.02 | buy |
| Capital Research Global Investors | 392,847 | 363,050 | -29,797 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 95,074 | 338,176 | +243,102 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 305,431 | 308,385 | +2,954 | 2.16 | 2.54 | +0.38 | buy |
| Sofinnova Investments, Inc. | 406,029 | 303,103 | -102,926 | 1.37 | 1.53 | +0.17 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 170,700 | 271,700 | +101,000 | 0.02 | 0.04 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 0 | 256,950 | +256,950 | 0.00 | 2.50 | +2.50 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 231,509 | 256,175 | +24,666 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 0 | 164,783 | +164,783 | 0.00 | 1.67 | +1.67 | buy |
| MILLENNIUM MANAGEMENT LLC | 327,860 | 147,200 | -180,660 | 0.02 | 0.01 | -0.01 | sell |
| FIRST TRUST ADVISORS LP | 0 | 128,424 | +128,424 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 93,696 | 100,957 | +7,261 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 90,300 | +90,300 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 62,516 | 75,721 | +13,205 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 38,973 | 73,416 | +34,443 | 0.03 | 0.06 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 50,183 | 62,201 | +12,018 | 0.01 | 0.01 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 61,545 | +61,545 | 0.00 | 0.08 | +0.08 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 32,539 | 59,841 | +27,302 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 39,305 | 58,358 | +19,053 | 0.06 | 0.10 | +0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 13,501 | 48,765 | +35,264 | 0.00 | 0.02 | +0.02 | buy |
| Western Standard LLC | 0 | 47,000 | +47,000 | 0.00 | 1.51 | +1.51 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 10,924 | 36,443 | +25,519 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 35,176 | 35,176 | 0 | 0.06 | 0.14 | +0.08 | hold |
| UBS Group AG | 48,137 | 35,019 | -13,118 | 0.00 | 0.00 | -0.00 | sell |
| HUSSMAN STRATEGIC ADVISORS, INC. | 0 | 31,500 | +31,500 | 0.00 | 0.69 | +0.69 | buy |
| Empyrean Capital Partners, LP | 0 | 30,000 | +30,000 | 0.00 | 0.10 | +0.10 | buy |
| Atom Investors LP | 26,505 | 29,594 | +3,089 | 0.13 | 0.25 | +0.12 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 28,678 | +28,678 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,671 | 28,678 | +3,007 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 28,814 | 28,653 | -161 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 25,874 | 26,200 | +326 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 26,011 | +26,011 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 23,077 | +23,077 | 0.00 | 0.19 | +0.19 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 22,584 | 22,584 | 0 | 0.03 | 0.03 | +0.00 | hold |
| D. E. Shaw & Co., Inc. | 77,437 | 22,322 | -55,115 | 0.00 | 0.00 | -0.00 | sell |
| Nicholas Investment Partners, LP | 0 | 21,443 | +21,443 | 0.00 | 0.11 | +0.11 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 25,785 | 21,421 | -4,364 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 20,222 | 21,145 | +923 | 0.00 | 0.00 | +0.00 | buy |
| Opaleye Management Inc. | 0 | 20,291 | +20,291 | 0.00 | 0.17 | +0.17 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 67 | 20,067 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 17,177 | 18,658 | +1,481 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 20,126 | 18,363 | -1,763 | 0.02 | 0.02 | -0.00 | sell |
| Verition Fund Management LLC | 0 | 17,993 | +17,993 | 0.00 | 0.01 | +0.01 | buy |
| Quantinno Capital Management LP | 17,704 | 17,396 | -308 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 97,873 | 17,272 | -80,601 | 0.01 | 0.00 | -0.01 | sell |
| Invesco Ltd. | 23,356 | 16,858 | -6,498 | 0.00 | 0.00 | -0.00 | sell |
| Ratan Capital Management LP | 0 | 16,612 | +16,612 | 0.00 | 0.51 | +0.51 | buy |
| SummitTX Capital, L.P. | 137,821 | 15,251 | -122,570 | 0.30 | 0.04 | -0.26 | sell |
| Swiss National Bank | 14,400 | 13,900 | -500 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 34,207 | 13,343 | -20,864 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 12,466 | +12,466 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 11,433 | 12,056 | +623 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 8,380 | 11,247 | +2,867 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 15,761 | 11,148 | -4,613 | 0.00 | 0.00 | -0.00 | sell |
| Tidal Investments LLC | 0 | 10,170 | +10,170 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 10,170 | +10,170 | 0.00 | 0.03 | +0.03 | buy |
| Janney Montgomery Scott LLC | 6,406 | 9,787 | +3,381 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 8,950 | 9,650 | +700 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 7,451 | 9,579 | +2,128 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,938 | 9,563 | +5,625 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 9,488 | 9,345 | -143 | 0.01 | 0.01 | +0.00 | sell |
| MARSHALL WACE, LLP | 20,888 | 8,800 | -12,088 | 0.00 | 0.00 | -0.00 | sell |
| Meridian Wealth Advisors, LLC | 10,500 | 8,500 | -2,000 | 0.09 | 0.09 | -0.00 | sell |
| NOMURA HOLDINGS INC | 0 | 8,000 | +8,000 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 7,012 | 7,812 | +800 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 491 | 7,747 | +7,256 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 7,649 | +7,649 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 15,639 | 6,543 | -9,096 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 6,618 | 6,514 | -104 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,472 | 6,326 | +2,854 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 0 | 6,146 | +6,146 | 0.00 | 0.14 | +0.14 | buy |
| Cannon Global Investment Management, LLC | 0 | 5,900 | +5,900 | 0.00 | 1.68 | +1.68 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 5,348 | 5,675 | +327 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 5,240 | 5,638 | +398 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 7,032 | 5,620 | -1,412 | 0.02 | 0.01 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 30,980 | 5,612 | -25,368 | 0.02 | 0.00 | -0.02 | sell |
| Qube Research & Technologies Ltd | 0 | 5,378 | +5,378 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 4,932 | 5,260 | +328 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 5,009 | 5,138 | +129 | 0.00 | 0.00 | +0.00 | buy |
| Persium Advisors, LLC | 0 | 4,875 | +4,875 | 0.00 | 0.30 | +0.30 | buy |
| Dynamic Advisor Solutions LLC | 0 | 4,824 | +4,824 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 4,728 | +4,728 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 4,569 | +4,569 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,800 | 4,276 | +476 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,228 | 4,206 | -22 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 20,222 | 4,064 | -16,158 | 0.00 | 0.00 | -0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 6,500 | 4,000 | -2,500 | 0.01 | 0.01 | -0.00 | sell |
| MACQUARIE GROUP LTD | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 3,800 | 3,900 | +100 | 0.02 | 0.03 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 3,425 | 3,549 | +124 | 0.06 | 0.08 | +0.01 | buy |
| NewEdge Wealth, LLC | 0 | 3,507 | +3,507 | 0.00 | 0.00 | +0.00 | buy |