| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,452,707 | 1,442,707 | -10,000 | 2.10 | 1.92 | -0.19 | sell |
| VIKING GLOBAL INVESTORS LP | 1,437,705 | 1,437,705 | 0 | 0.30 | 0.27 | -0.03 | hold |
| MORGAN STANLEY | 1,167,728 | 1,263,078 | +95,350 | 0.01 | 0.01 | -0.00 | buy |
| Sanofi | 1,157,926 | 1,157,926 | 0 | 29.47 | 23.17 | -6.30 | hold |
| HighTower Advisors, LLC | 870,507 | 870,200 | -307 | 0.08 | 0.06 | -0.01 | sell |
| BlackRock, Inc. | 777,383 | 798,898 | +21,515 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 374,961 | 550,845 | +175,884 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 454,657 | 406,029 | -48,628 | 1.55 | 1.37 | -0.18 | sell |
| Capital Research Global Investors | 421,575 | 392,847 | -28,728 | 0.01 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 139,479 | 384,433 | +244,954 | 0.04 | 0.10 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 275,917 | 327,860 | +51,943 | 0.02 | 0.02 | +0.00 | buy |
| PFM Health Sciences, LP | 265,517 | 305,431 | +39,914 | 2.12 | 2.16 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 214,725 | 254,827 | +40,102 | 0.09 | 0.14 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 226,009 | 231,509 | +5,500 | 0.00 | 0.00 | -0.00 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 264,000 | 170,700 | -93,300 | 0.04 | 0.02 | -0.02 | sell |
| SummitTX Capital, L.P. | 82,885 | 137,821 | +54,936 | 0.20 | 0.30 | +0.10 | buy |
| Soleus Capital Management, L.P. | 25,000 | 131,000 | +106,000 | 0.08 | 0.36 | +0.27 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 297,116 | 97,873 | -199,243 | 0.03 | 0.01 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 100,617 | 95,074 | -5,543 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 88,509 | 93,696 | +5,187 | 0.00 | 0.00 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 122,101 | 77,437 | -44,664 | 0.01 | 0.00 | -0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 71,488 | 72,812 | +1,324 | 0.12 | 0.10 | -0.02 | buy |
| CITIGROUP INC | 55,759 | 62,516 | +6,757 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 46,269 | 52,808 | +6,539 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 52,600 | 50,183 | -2,417 | 0.01 | 0.01 | -0.00 | sell |
| UBS Group AG | 73,699 | 48,137 | -25,562 | 0.00 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 15,008 | 39,305 | +24,297 | 0.03 | 0.06 | +0.03 | buy |
| Jefferies Financial Group Inc. | 8,901 | 38,973 | +30,072 | 0.01 | 0.03 | +0.03 | buy |
| ArrowMark Colorado Holdings LLC | 35,176 | 35,176 | 0 | 0.06 | 0.06 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 29,308 | 34,207 | +4,899 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 26,900 | 33,157 | +6,257 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 69,119 | 32,683 | -36,436 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 14,850 | 32,539 | +17,689 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 30,980 | +30,980 | 0.00 | 0.02 | +0.02 | buy |
| Jump Financial, LLC | 3,504 | 29,300 | +25,796 | 0.00 | 0.03 | +0.03 | buy |
| Corient Private Wealth LLC | 20,443 | 28,814 | +8,371 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 26,505 | +26,505 | 0.00 | 0.13 | +0.13 | buy |
| Bank of New York Mellon Corp | 26,748 | 25,874 | -874 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 28,393 | 25,785 | -2,608 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,341 | 25,671 | -1,670 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 112,396 | 23,356 | -89,040 | 0.00 | 0.00 | -0.00 | sell |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 22,883 | 22,584 | -299 | 0.03 | 0.03 | -0.01 | sell |
| MARSHALL WACE, LLP | 29,310 | 20,888 | -8,422 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 20,778 | 20,222 | -556 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 9,021 | 20,126 | +11,105 | 0.02 | 0.02 | +0.00 | buy |
| Centiva Capital, LP | 0 | 17,739 | +17,739 | 0.00 | 0.06 | +0.06 | buy |
| Quantinno Capital Management LP | 10,038 | 17,704 | +7,666 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 17,090 | 17,177 | +87 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 8,582 | 15,761 | +7,179 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 3,398 | 15,639 | +12,241 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 14,400 | +14,400 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 13,501 | +13,501 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 11,435 | 11,433 | -2 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 10,141 | 11,329 | +1,188 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,963 | 10,924 | -1,039 | 0.00 | 0.00 | -0.00 | sell |
| Meridian Wealth Advisors, LLC | 10,500 | 10,500 | 0 | 0.11 | 0.09 | -0.02 | hold |
| Ethic Inc. | 12,971 | 9,488 | -3,483 | 0.02 | 0.01 | -0.01 | sell |
| JANE STREET GROUP, LLC | 33,019 | 9,196 | -23,823 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 8,950 | 8,950 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AQR CAPITAL MANAGEMENT LLC | 7,501 | 8,380 | +879 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 6,638 | 7,451 | +813 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 4,642 | 7,373 | +2,731 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 7,274 | +7,274 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 3,271 | 7,032 | +3,761 | 0.01 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 5,334 | 7,012 | +1,678 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 5,708 | 6,618 | +910 | 0.00 | 0.00 | -0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 9,000 | 6,500 | -2,500 | 0.01 | 0.01 | -0.01 | sell |
| Harvest Investment Services, LLC | 5,049 | 6,413 | +1,364 | 0.08 | 0.08 | +0.00 | buy |
| Janney Montgomery Scott LLC | 5,495 | 6,406 | +911 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 5,531 | +5,531 | 0.00 | 0.03 | +0.03 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 5,564 | 5,512 | -52 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,712 | 5,348 | +636 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 5,242 | +5,242 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 5,320 | 5,240 | -80 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 794 | 5,009 | +4,215 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 17,059 | 4,932 | -12,127 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 5,358 | 4,803 | -555 | 0.01 | 0.01 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 2,785 | 4,228 | +1,443 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 10,813 | 3,938 | -6,875 | 0.00 | 0.00 | -0.00 | sell |
| NBC SECURITIES, INC. | 3,000 | 3,800 | +800 | 0.02 | 0.02 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 3,800 | 3,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,472 | 3,472 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtus Investment Advisers, LLC | 3,343 | 3,425 | +82 | 0.07 | 0.06 | -0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 3,400 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Presidio Capital Management, LLC | 3,394 | 3,394 | 0 | 0.08 | 0.07 | -0.01 | hold |
| Moran Wealth Management, LLC | 0 | 3,163 | +3,163 | 0.00 | 0.01 | +0.01 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 3,101 | 3,026 | -75 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 2,660 | 2,660 | 0 | 0.00 | 0.00 | -0.00 | hold |
| China Universal Asset Management Co., Ltd. | 2,370 | 2,581 | +211 | 0.01 | 0.01 | -0.00 | buy |
| BARCLAYS PLC | 21,879 | 1,667 | -20,212 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 0 | 1,600 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 659 | 1,388 | +729 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 1,200 | 1,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Caption Management, LLC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Optiver Holding B.V. | 932 | 962 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 707 | 759 | +52 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 736 | 736 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 558 | 491 | -67 | 0.00 | 0.00 | -0.00 | sell |
| GF FUND MANAGEMENT CO. LTD. | 285 | 326 | +41 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 528 | 302 | -226 | 0.00 | 0.00 | -0.00 | sell |