| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 0 | 1,787,705 | +1,787,705 | 0.00 | 0.10 | +0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,064,026 | +1,064,026 | 0.00 | 0.36 | +0.36 | buy |
| VANGUARD GROUP INC | 0 | 478,028 | +478,028 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 474,999 | +474,999 | 0.00 | 0.07 | +0.07 | buy |
| Sofinnova Investments, Inc. | 0 | 463,315 | +463,315 | 0.00 | 0.41 | +0.41 | buy |
| Slotnik Capital, LLC | 0 | 341,605 | +341,605 | 0.00 | 2.48 | +2.48 | buy |
| ALPINE ASSOCIATES MANAGEMENT INC. | 0 | 305,967 | +305,967 | 0.00 | 0.21 | +0.21 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 303,196 | +303,196 | 0.00 | 0.00 | +0.00 | buy |
| TIG Advisors, LLC | 0 | 243,650 | +243,650 | 0.00 | 0.28 | +0.28 | buy |
| MORGAN STANLEY | 0 | 235,916 | +235,916 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 230,000 | +230,000 | 0.00 | 1.02 | +1.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 210,317 | +210,317 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 199,998 | +199,998 | 0.00 | 0.30 | +0.30 | buy |
| MARSHALL WACE, LLP | 0 | 197,500 | +197,500 | 0.00 | 0.00 | +0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 167,500 | +167,500 | 0.00 | 0.24 | +0.24 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 164,971 | +164,971 | 0.00 | 0.05 | +0.05 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 152,159 | +152,159 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 0 | 148,586 | +148,586 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 141,400 | +141,400 | 0.00 | 0.00 | +0.00 | buy |
| PFM Health Sciences, LP | 0 | 135,546 | +135,546 | 0.00 | 0.10 | +0.10 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 127,500 | +127,500 | 0.00 | 0.00 | +0.00 | buy |
| MMCAP International Inc. SPC | 0 | 112,858 | +112,858 | 0.00 | 0.22 | +0.22 | buy |
| CSS LLC/IL | 0 | 110,651 | +110,651 | 0.00 | 0.12 | +0.12 | buy |
| HighTower Advisors, LLC | 0 | 107,500 | +107,500 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 102,761 | +102,761 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 88,470 | +88,470 | 0.00 | 0.11 | +0.11 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 81,112 | +81,112 | 0.00 | 0.03 | +0.03 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 75,980 | +75,980 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 0 | 74,068 | +74,068 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 70,564 | +70,564 | 0.00 | 0.00 | +0.00 | buy |
| Westchester Capital Management, LLC | 0 | 64,339 | +64,339 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 0 | 44,265 | +44,265 | 0.00 | 0.00 | +0.00 | buy |
| BLUEFIN CAPITAL MANAGEMENT, LLC | 0 | 33,275 | +33,275 | 0.00 | 0.13 | +0.13 | buy |
| Laird Norton Wetherby Wealth Management, LLC | 0 | 32,682 | +32,682 | 0.00 | 0.02 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 31,678 | +31,678 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 31,326 | +31,326 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 28,229 | +28,229 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 26,772 | +26,772 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 23,232 | +23,232 | 0.00 | 0.02 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 0 | 22,577 | +22,577 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 21,386 | +21,386 | 0.00 | 0.00 | +0.00 | buy |
| JBF Capital, Inc. | 0 | 20,949 | +20,949 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 19,210 | +19,210 | 0.00 | 0.00 | +0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 18,263 | +18,263 | 0.00 | 0.05 | +0.05 | buy |
| Murchinson Ltd. | 0 | 17,370 | +17,370 | 0.00 | 0.05 | +0.05 | buy |
| RHUMBLINE ADVISERS | 0 | 14,159 | +14,159 | 0.00 | 0.00 | +0.00 | buy |
| Alpine Global Management, LLC | 0 | 12,445 | +12,445 | 0.00 | 0.03 | +0.03 | buy |
| Birchview Capital, LP | 0 | 12,110 | +12,110 | 0.00 | 0.16 | +0.16 | buy |
| ALPS ADVISORS INC | 0 | 11,276 | +11,276 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 4,823 | +4,823 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 4,521 | +4,521 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 4,192 | +4,192 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 4,071 | +4,071 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 3,579 | +3,579 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 3,473 | +3,473 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,902 | +2,902 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 0 | 2,175 | +2,175 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,900 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,105 | +1,105 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 853 | +853 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 759 | +759 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 362 | +362 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 186 | +186 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 171 | +171 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 144 | +144 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 123 | +123 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 122 | +122 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 118 | +118 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |