| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VIKING GLOBAL INVESTORS LP | 1,787,705 | 1,787,705 | 0 | 0.07 | 0.16 | +0.08 | hold |
| PERCEPTIVE ADVISORS LLC | 977,892 | 1,327,707 | +349,815 | 0.52 | 1.29 | +0.77 | buy |
| Sanofi | 1,157,926 | 1,157,926 | 0 | 9.40 | 14.98 | +5.58 | hold |
| HighTower Advisors, LLC | 871,759 | 871,759 | 0 | 0.02 | 0.03 | +0.02 | hold |
| BlackRock, Inc. | 728,744 | 684,746 | -43,998 | 0.00 | 0.00 | +0.00 | sell |
| VANGUARD GROUP INC | 598,448 | 594,918 | -3,530 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 0 | 442,856 | +442,856 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 708,678 | 440,092 | -268,586 | 0.69 | 0.91 | +0.22 | sell |
| Woodline Partners LP | 662,868 | 336,590 | -326,278 | 0.05 | 0.05 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 275,778 | 297,820 | +22,042 | 0.00 | 0.01 | +0.00 | buy |
| PFM Health Sciences, LP | 244,261 | 239,644 | -4,617 | 0.30 | 0.69 | +0.39 | sell |
| Caligan Partners LP | 0 | 236,383 | +236,383 | 0.00 | 1.10 | +1.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 225,955 | 221,920 | -4,035 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 204,959 | 203,923 | -1,036 | 0.00 | 0.00 | +0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 26,834 | 170,158 | +143,324 | 0.02 | 0.28 | +0.26 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 177,318 | 161,909 | -15,409 | 0.06 | 0.12 | +0.06 | sell |
| Schonfeld Strategic Advisors LLC | 154,790 | 97,382 | -57,408 | 0.02 | 0.02 | +0.01 | sell |
| NORTHERN TRUST CORP | 97,685 | 92,657 | -5,028 | 0.00 | 0.00 | +0.00 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 28,230 | 78,812 | +50,582 | 0.01 | 0.07 | +0.05 | buy |
| JANE STREET GROUP, LLC | 19,373 | 62,941 | +43,568 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 57,194 | +57,194 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 0 | 54,143 | +54,143 | 0.00 | 0.08 | +0.08 | buy |
| Bank of New York Mellon Corp | 50,478 | 50,125 | -353 | 0.00 | 0.00 | +0.00 | sell |
| Groupe la Francaise | 75,932 | 47,334 | -28,598 | 0.02 | 0.02 | +0.00 | sell |
| Slotnik Capital, LLC | 184,171 | 41,401 | -142,770 | 1.06 | 0.50 | -0.56 | sell |
| Laird Norton Wetherby Wealth Management, LLC | 40,656 | 40,656 | 0 | 0.03 | 0.06 | +0.03 | hold |
| FMR LLC | 39,071 | 39,327 | +256 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 29,993 | 38,134 | +8,141 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 36,206 | 35,176 | -1,030 | 0.01 | 0.02 | +0.01 | sell |
| Birchview Capital, LP | 32,110 | 31,698 | -412 | 0.46 | 0.81 | +0.35 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 29,759 | +29,759 | 0.00 | 0.00 | +0.00 | buy |
| CREDIT INDUSTRIEL ET COMMERCIAL | 64,217 | 28,958 | -35,259 | 0.15 | 0.16 | +0.01 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 120,124 | 28,445 | -91,679 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,793 | 27,793 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARSHALL WACE, LLP | 0 | 27,242 | +27,242 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 11,089 | 25,966 | +14,877 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Advisors, LLC | 25,000 | 25,000 | 0 | 0.06 | 0.12 | +0.06 | hold |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 22,584 | 22,584 | 0 | 0.01 | 0.02 | +0.01 | hold |
| ALLIANCEBERNSTEIN L.P. | 20,420 | 19,230 | -1,190 | 0.00 | 0.00 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 0 | 17,832 | +17,832 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 21,214 | 17,584 | -3,630 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 13,492 | 17,574 | +4,082 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 11,954 | 17,342 | +5,388 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 22,170 | 17,164 | -5,006 | 0.00 | 0.00 | +0.00 | sell |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,500 | 16,500 | 0 | 0.01 | 0.01 | +0.01 | hold |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 16,377 | +16,377 | 0.00 | 0.57 | +0.57 | buy |
| Caption Management, LLC | 199,508 | 15,513 | -183,995 | 0.26 | 0.03 | -0.23 | sell |
| Ethic Inc. | 15,739 | 14,487 | -1,252 | 0.00 | 0.01 | +0.00 | sell |
| RHUMBLINE ADVISERS | 14,334 | 13,735 | -599 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 13,719 | +13,719 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 17,164 | 13,468 | -3,696 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 0 | 11,827 | +11,827 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 11,553 | +11,553 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 8,400 | +8,400 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 7,626 | +7,626 | 0.00 | 0.06 | +0.06 | buy |
| WELLS FARGO & COMPANY/MN | 6,466 | 7,599 | +1,133 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 7,683 | 7,425 | -258 | 0.00 | 0.00 | +0.00 | sell |
| Dynamic Technology Lab Private Ltd | 0 | 7,388 | +7,388 | 0.00 | 0.04 | +0.04 | buy |
| Belvedere Trading LLC | 0 | 6,277 | +6,277 | 0.00 | 0.02 | +0.02 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 6,003 | +6,003 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 5,998 | +5,998 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 3,332 | 4,971 | +1,639 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 5,308 | 4,829 | -479 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,954 | 4,130 | -824 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,472 | 3,472 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NBC SECURITIES, INC. | 0 | 3,000 | +3,000 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 3,374 | 2,660 | -714 | 0.00 | 0.00 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 2,907 | 2,539 | -368 | 0.00 | 0.01 | +0.00 | sell |
| NATIXIS | 2,000 | 2,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 1,097 | 1,886 | +789 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 1,200 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,216 | 1,043 | -1,173 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 853 | 853 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 768 | 768 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 245 | 625 | +380 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 568 | +568 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 559 | 560 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 737 | 498 | -239 | 0.00 | 0.00 | +0.00 | sell |
| AMALGAMATED BANK | 362 | 362 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 359 | 307 | -52 | 0.00 | 0.00 | +0.00 | sell |
| Wealthspire Advisors, LLC | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| FNY Investment Advisers, LLC | 250 | 250 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 0 | 217 | +217 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 168 | 168 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CWM, LLC | 125 | 148 | +23 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 155 | 139 | -16 | 0.00 | 0.00 | +0.00 | sell |
| Optiver Holding B.V. | 0 | 114 | +114 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 75 | +75 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 22 | 40 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 1 | 38 | +37 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 20 | 20 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rockefeller Capital Management L.P. | 0 | 13 | +13 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 11 | 11 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sunbelt Securities, Inc. | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 4 | 4 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 23,073 | 0 | -23,073 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 19,783 | 0 | -19,783 | 0.00 | 0.00 | -0.00 | sell |
| JBF Capital, Inc. | 20,949 | 0 | -20,949 | 0.05 | 0.00 | -0.05 | sell |