| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 1,327,707 | 1,452,707 | +125,000 | 1.29 | 2.10 | +0.81 | buy |
| VIKING GLOBAL INVESTORS LP | 1,787,705 | 1,437,705 | -350,000 | 0.16 | 0.30 | +0.15 | sell |
| MORGAN STANLEY | 442,856 | 1,167,728 | +724,872 | 0.00 | 0.01 | +0.00 | buy |
| Sanofi | 1,157,926 | 1,157,926 | 0 | 14.98 | 29.47 | +14.49 | hold |
| HighTower Advisors, LLC | 871,759 | 870,507 | -1,252 | 0.03 | 0.08 | +0.04 | sell |
| BlackRock, Inc. | 684,746 | 777,383 | +92,637 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 594,918 | 623,084 | +28,166 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 440,092 | 454,657 | +14,565 | 0.91 | 1.55 | +0.64 | buy |
| Capital Research Global Investors | 0 | 421,575 | +421,575 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 203,923 | 374,961 | +171,038 | 0.00 | 0.00 | +0.00 | buy |
| Caligan Partners LP | 236,383 | 323,565 | +87,182 | 1.10 | 2.34 | +1.24 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 297,116 | +297,116 | 0.00 | 0.03 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 297,820 | 275,917 | -21,903 | 0.01 | 0.02 | +0.01 | sell |
| PFM Health Sciences, LP | 239,644 | 265,517 | +25,873 | 0.69 | 2.12 | +1.44 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 264,000 | +264,000 | 0.00 | 0.04 | +0.04 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 221,920 | 226,009 | +4,089 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 97,382 | 214,725 | +117,343 | 0.02 | 0.09 | +0.06 | buy |
| Woodline Partners LP | 336,590 | 139,479 | -197,111 | 0.05 | 0.04 | -0.01 | sell |
| NORGES BANK | 0 | 133,300 | +133,300 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 11,553 | 122,101 | +110,548 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 17,574 | 112,396 | +94,822 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 25,966 | 100,617 | +74,651 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 78,812 | 92,009 | +13,197 | 0.07 | 0.19 | +0.12 | buy |
| NORTHERN TRUST CORP | 92,657 | 88,509 | -4,148 | 0.00 | 0.00 | +0.00 | sell |
| SummitTX Capital, L.P. | 54,143 | 82,885 | +28,742 | 0.08 | 0.20 | +0.12 | buy |
| UBS Group AG | 0 | 73,699 | +73,699 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 161,909 | 71,488 | -90,421 | 0.12 | 0.12 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 17,832 | 69,119 | +51,287 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 4,971 | 55,759 | +50,788 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 8,400 | 52,600 | +44,200 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 39,327 | 46,269 | +6,942 | 0.00 | 0.00 | +0.00 | buy |
| Laird Norton Wetherby Trust Company, LLC | 0 | 40,382 | +40,382 | 0.00 | 0.07 | +0.07 | buy |
| ArrowMark Colorado Holdings LLC | 35,176 | 35,176 | 0 | 0.02 | 0.06 | +0.04 | hold |
| JANE STREET GROUP, LLC | 62,941 | 33,019 | -29,922 | 0.00 | 0.00 | +0.00 | sell |
| MARSHALL WACE, LLP | 27,242 | 29,310 | +2,068 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 17,164 | 29,308 | +12,144 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 29,759 | 28,393 | -1,366 | 0.00 | 0.00 | +0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 27,793 | 27,341 | -452 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 57,194 | 26,900 | -30,294 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 50,125 | 26,748 | -23,377 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 28,445 | 25,390 | -3,055 | 0.00 | 0.00 | +0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 25,000 | +25,000 | 0.00 | 0.08 | +0.08 | buy |
| Empirical Financial Services, LLC d.b.a. Empirical Wealth Management | 22,584 | 22,883 | +299 | 0.02 | 0.03 | +0.02 | buy |
| BARCLAYS PLC | 13,468 | 21,879 | +8,411 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 38,134 | 20,778 | -17,356 | 0.00 | 0.00 | +0.00 | sell |
| Corient Private Wealth LLC | 0 | 20,443 | +20,443 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 17,584 | 17,090 | -494 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 4,829 | 17,059 | +12,230 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 16,377 | 16,377 | 0 | 0.57 | 0.88 | +0.31 | hold |
| SG Americas Securities, LLC | 0 | 16,088 | +16,088 | 0.00 | 0.00 | +0.00 | buy |
| Groupe la Francaise | 47,334 | 15,636 | -31,698 | 0.02 | 0.02 | -0.00 | sell |
| Voleon Capital Management LP | 0 | 15,008 | +15,008 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,886 | 14,850 | +12,964 | 0.00 | 0.00 | +0.00 | buy |
| Ethic Inc. | 14,487 | 12,971 | -1,516 | 0.01 | 0.02 | +0.01 | sell |
| Mariner, LLC | 17,342 | 12,746 | -4,596 | 0.00 | 0.00 | +0.00 | sell |
| Jain Global LLC | 0 | 12,098 | +12,098 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 11,963 | +11,963 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,735 | 11,435 | -2,300 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 7,599 | 10,813 | +3,214 | 0.00 | 0.00 | +0.00 | buy |
| Meridian Wealth Advisors, LLC | 25,000 | 10,500 | -14,500 | 0.12 | 0.11 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 13,719 | 10,141 | -3,578 | 0.00 | 0.00 | +0.00 | sell |
| Quantinno Capital Management LP | 11,827 | 10,038 | -1,789 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 0 | 9,021 | +9,021 | 0.00 | 0.02 | +0.02 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 16,500 | 9,000 | -7,500 | 0.01 | 0.01 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 19,230 | 8,950 | -10,280 | 0.00 | 0.00 | +0.00 | sell |
| Jefferies Financial Group Inc. | 0 | 8,901 | +8,901 | 0.00 | 0.01 | +0.01 | buy |
| CREDIT INDUSTRIEL ET COMMERCIAL | 28,958 | 8,656 | -20,302 | 0.16 | 0.10 | -0.06 | sell |
| Rafferty Asset Management, LLC | 0 | 8,582 | +8,582 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 5,998 | 7,501 | +1,503 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 6,277 | 7,402 | +1,125 | 0.02 | 0.11 | +0.09 | buy |
| DEUTSCHE BANK AG\ | 0 | 6,638 | +6,638 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 5,708 | +5,708 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 5,564 | +5,564 | 0.00 | 0.00 | +0.00 | buy |
| Janney Montgomery Scott LLC | 0 | 5,495 | +5,495 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 5,358 | +5,358 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 5,334 | +5,334 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 7,425 | 5,320 | -2,105 | 0.00 | 0.00 | +0.00 | sell |
| Harvest Investment Services, LLC | 0 | 5,049 | +5,049 | 0.00 | 0.08 | +0.08 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,130 | 4,712 | +582 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 4,642 | +4,642 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 3,800 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 31,698 | 3,698 | -28,000 | 0.81 | 0.17 | -0.64 | sell |
| Jump Financial, LLC | 0 | 3,504 | +3,504 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,472 | 3,472 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 0 | 3,398 | +3,398 | 0.00 | 0.00 | +0.00 | buy |
| Presidio Capital Management, LLC | 0 | 3,394 | +3,394 | 0.00 | 0.08 | +0.08 | buy |
| Virtus Investment Advisers, LLC | 0 | 3,343 | +3,343 | 0.00 | 0.07 | +0.07 | buy |
| PROFUND ADVISORS LLC | 0 | 3,271 | +3,271 | 0.00 | 0.01 | +0.01 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 3,242 | +3,242 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 3,101 | +3,101 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 3,051 | +3,051 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 3,000 | 3,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 2,785 | +2,785 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,660 | 2,660 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 2,539 | 2,370 | -169 | 0.01 | 0.01 | +0.01 | sell |
| AlphaQuest LLC | 0 | 2,192 | +2,192 | 0.00 | 0.01 | +0.01 | buy |
| Hurley Capital, LLC | 0 | 1,660 | +1,660 | 0.00 | 0.07 | +0.07 | buy |
| DIADEMA PARTNERS LP | 0 | 1,299 | +1,299 | 0.00 | 0.06 | +0.06 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 1,200 | 1,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIMPLEX TRADING, LLC | 0 | 1,145 | +1,145 | 0.00 | 0.00 | +0.00 | buy |