| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,111,865 | 7,168,939 | +57,074 | 0.01 | 0.01 | +0.00 | buy |
| TRV GP V, LLC | 7,135,233 | 7,135,233 | 0 | 50.44 | 55.68 | +5.23 | hold |
| ARCH Venture Management, LLC | 3,728,738 | 3,728,738 | 0 | 17.36 | 17.23 | -0.13 | hold |
| Capital International Investors | 3,402,529 | 3,097,973 | -304,556 | 0.02 | 0.02 | +0.01 | sell |
| Cormorant Asset Management, LP | 3,027,521 | 2,957,521 | -70,000 | 5.21 | 4.67 | -0.54 | sell |
| GOLDMAN SACHS GROUP INC | 3,001,879 | 2,942,251 | -59,628 | 0.01 | 0.01 | -0.00 | sell |
| BlackRock, Inc. | 2,431,862 | 2,505,955 | +74,093 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 1,904,408 | 1,904,408 | 0 | 2.49 | 2.99 | +0.49 | hold |
| JOHNSON & JOHNSON | 1,784,517 | 1,784,517 | 0 | 9.75 | 8.56 | -1.20 | hold |
| Polar Capital Holdings Plc | 1,004,728 | 1,642,461 | +637,733 | 0.14 | 0.22 | +0.09 | buy |
| BAKER BROS. ADVISORS LP | 1,547,090 | 1,547,090 | 0 | 0.27 | 0.28 | +0.00 | hold |
| Vestal Point Capital, LP | 1,110,000 | 1,436,229 | +326,229 | 1.24 | 1.26 | +0.02 | buy |
| TRV GP VI, LLC | 969,218 | 969,218 | 0 | 19.80 | 22.37 | +2.57 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 952,371 | 918,866 | -33,505 | 0.01 | 0.01 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 881,609 | 866,456 | -15,153 | 0.00 | 0.00 | +0.00 | sell |
| STATE STREET CORP | 714,821 | 759,552 | +44,731 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 788,411 | 727,843 | -60,568 | 0.01 | 0.01 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 694,734 | 721,622 | +26,888 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 673,923 | 673,923 | 0 | 0.37 | 0.42 | +0.04 | hold |
| Siren, L.L.C. | 708,469 | 641,469 | -67,000 | 0.64 | 0.56 | -0.08 | sell |
| T. Rowe Price Investment Management, Inc. | 619,029 | 620,600 | +1,571 | 0.01 | 0.01 | +0.00 | buy |
| Capital World Investors | 0 | 536,607 | +536,607 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 185,265 | 366,809 | +181,544 | 0.93 | 1.65 | +0.72 | buy |
| MILLENNIUM MANAGEMENT LLC | 201,825 | 319,552 | +117,727 | 0.00 | 0.01 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 178,737 | 257,431 | +78,694 | 0.11 | 0.17 | +0.06 | buy |
| Burkehill Global Management, LP | 250,000 | 250,000 | 0 | 0.50 | 0.39 | -0.11 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 244,391 | 239,917 | -4,474 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 220,815 | 237,992 | +17,177 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 83,487 | 224,498 | +141,011 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 194,200 | 194,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Candriam S.C.A. | 0 | 185,925 | +185,925 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 247,315 | 175,449 | -71,866 | 0.01 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 267,120 | 171,757 | -95,363 | 0.00 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 210,331 | 165,954 | -44,377 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 226,360 | 151,758 | -74,602 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 150,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Artia Global Partners LP | 138,508 | 138,508 | 0 | 0.68 | 0.98 | +0.30 | hold |
| Freestone Grove Partners LP | 0 | 127,783 | +127,783 | 0.00 | 0.03 | +0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 254,967 | 114,815 | -140,152 | 0.01 | 0.00 | -0.00 | sell |
| Swedbank AB | 113,200 | 113,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 34,553 | 110,826 | +76,273 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 115,190 | 99,078 | -16,112 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 56,484 | 78,799 | +22,315 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 56,457 | 78,231 | +21,774 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,659 | 75,359 | -3,300 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 75,000 | 75,000 | 0 | 0.53 | 0.53 | +0.01 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 66,149 | 72,948 | +6,799 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 74,081 | 72,319 | -1,762 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 70,946 | 71,508 | +562 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 54,600 | 56,500 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 46,849 | 56,292 | +9,443 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 13,062 | 47,903 | +34,841 | 0.01 | 0.03 | +0.02 | buy |
| ALPS ADVISORS INC | 39,139 | 38,907 | -232 | 0.01 | 0.01 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 12,353 | 35,952 | +23,599 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 35,825 | +35,825 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 30,726 | 34,533 | +3,807 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 26,690 | 33,426 | +6,736 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,282 | 32,918 | +30,636 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 18,268 | 30,819 | +12,551 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 50,619 | 28,103 | -22,516 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 20,878 | 25,510 | +4,632 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 38,925 | 25,421 | -13,504 | 0.95 | 0.69 | -0.26 | sell |
| DEUTSCHE BANK AG\ | 21,535 | 24,169 | +2,634 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 8,297 | 23,914 | +15,617 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 7,031 | 22,784 | +15,753 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 62,979 | 20,984 | -41,995 | 0.02 | 0.00 | -0.01 | sell |
| Legal & General Group Plc | 22,384 | 17,154 | -5,230 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 15,996 | 15,996 | 0 | 0.00 | 0.00 | +0.00 | hold |
| JPMORGAN CHASE & CO | 15,129 | 15,846 | +717 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 10,208 | 15,672 | +5,464 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 12,212 | 15,519 | +3,307 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 14,656 | +14,656 | 0.00 | 0.23 | +0.23 | buy |
| AMERIPRISE FINANCIAL INC | 14,794 | 14,585 | -209 | 0.00 | 0.00 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 13,800 | 13,800 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,249 | 13,618 | +369 | 0.00 | 0.00 | -0.00 | buy |
| Allianz Asset Management GmbH | 13,200 | 13,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 10,766 | 12,058 | +1,292 | 0.03 | 0.03 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 44,291 | 11,789 | -32,502 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 11,148 | +11,148 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 32,109 | 11,116 | -20,993 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,300 | 11,000 | +3,700 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| CATALYST PRIVATE WEALTH, LLC | 10,000 | 10,000 | 0 | 0.13 | 0.17 | +0.04 | hold |
| GSA CAPITAL PARTNERS LLP | 12,733 | 9,928 | -2,805 | 0.03 | 0.02 | -0.01 | sell |
| State of New Jersey Common Pension Fund D | 0 | 9,773 | +9,773 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 118,814 | 9,700 | -109,114 | 0.01 | 0.00 | -0.01 | sell |
| BARCLAYS PLC | 52,480 | 9,611 | -42,869 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 6,823 | 9,023 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,789 | 9,007 | +218 | 0.07 | 0.08 | +0.01 | buy |
| Arizona State Retirement System | 7,726 | 7,854 | +128 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 7,531 | +7,531 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,471 | 7,471 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 8,026 | 7,035 | -991 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 0 | 6,868 | +6,868 | 0.00 | 0.00 | +0.00 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 6,753 | +6,753 | 0.00 | 0.02 | +0.02 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 6,612 | +6,612 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 6,493 | +6,493 | 0.00 | 0.01 | +0.01 | buy |
| ProShare Advisors LLC | 7,308 | 6,394 | -914 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 5,900 | 5,900 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Tower Research Capital LLC (TRC) | 430 | 3,792 | +3,362 | 0.00 | 0.00 | +0.00 | buy |