| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 4,983,351 | +4,983,351 | 0.00 | 0.01 | +0.01 | buy |
| ARCH Venture Management, LLC | 0 | 3,728,738 | +3,728,738 | 0.00 | 32.60 | +32.60 | buy |
| Cormorant Asset Management, LP | 0 | 2,940,283 | +2,940,283 | 0.00 | 3.98 | +3.98 | buy |
| Capital International Investors | 0 | 2,602,531 | +2,602,531 | 0.00 | 0.01 | +0.01 | buy |
| JOHNSON & JOHNSON | 0 | 2,498,051 | +2,498,051 | 0.00 | 14.50 | +14.50 | buy |
| Sofinnova Investments, Inc. | 0 | 1,951,562 | +1,951,562 | 0.00 | 2.86 | +2.86 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 1,535,151 | +1,535,151 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 1,360,605 | +1,360,605 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 1,090,858 | +1,090,858 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 748,183 | +748,183 | 0.00 | 0.42 | +0.42 | buy |
| CITADEL ADVISORS LLC | 0 | 592,458 | +592,458 | 0.00 | 0.01 | +0.01 | buy |
| Artal Group S.A. | 0 | 350,000 | +350,000 | 0.00 | 0.21 | +0.21 | buy |
| Logos Global Management LP | 0 | 208,910 | +208,910 | 0.00 | 0.50 | +0.50 | buy |
| Woodline Partners LP | 0 | 171,100 | +171,100 | 0.00 | 0.04 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 116,782 | +116,782 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 101,522 | +101,522 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 75,516 | +75,516 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 70,000 | +70,000 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 0 | 70,000 | +70,000 | 0.00 | 0.62 | +0.62 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| LMR Partners LLP | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| Monashee Investment Management LLC | 0 | 40,000 | +40,000 | 0.00 | 0.12 | +0.12 | buy |
| Alyeska Investment Group, L.P. | 0 | 34,731 | +34,731 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 30,000 | +30,000 | 0.00 | 0.02 | +0.02 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.39 | +0.39 | buy |
| Squarepoint Ops LLC | 0 | 16,345 | +16,345 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 13,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 9,400 | +9,400 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 0 | 5,000 | +5,000 | 0.00 | 0.15 | +0.15 | buy |
| Tidemark, LLC | 0 | 1,088 | +1,088 | 0.00 | 0.01 | +0.01 | buy |