| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 0 | 550,090 | +550,090 | 0.00 | 0.06 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,073,208 | 1,525,519 | +452,311 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 64,747 | 273,507 | +208,760 | 0.00 | 0.00 | +0.00 | buy |
| Affinity Asset Advisors, LLC | 0 | 199,643 | +199,643 | 0.00 | 0.34 | +0.34 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 179,860 | +179,860 | 0.00 | 1.35 | +1.35 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 131,340 | +131,340 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 191,122 | 298,708 | +107,586 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,167,251 | 1,219,201 | +51,950 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,109,625 | 1,154,688 | +45,063 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 203,242 | 243,880 | +40,638 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 162,818 | 196,870 | +34,052 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 78,931 | 100,424 | +21,493 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 315,663 | 333,159 | +17,496 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 16,972 | +16,972 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 15,600 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 11,462 | +11,462 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 11,230 | +11,230 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 10,602 | +10,602 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 14,358 | 24,949 | +10,591 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 62,696 | 71,108 | +8,412 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 35,482 | 40,104 | +4,622 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 16,400 | 20,000 | +3,600 | 0.19 | 0.32 | +0.13 | buy |
| Woodline Partners LP | 182,028 | 185,028 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 90,968 | 93,497 | +2,529 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,967 | 11,267 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 1,353 | +1,353 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 922 | 2,100 | +1,178 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 941 | 1,793 | +852 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,209 | 1,961 | +752 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 145 | 474 | +329 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 998 | 1,304 | +306 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,266 | 1,410 | +144 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 137 | 205 | +68 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Rise Advisors, LLC | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 3 | 44 | +41 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 59 | 85 | +26 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 3 | +3 | 0.00 | 0.00 | +0.00 | buy |
| ARCH Venture Management, LLC | 3,728,738 | 3,728,738 | 0 | 18.21 | 14.19 | -4.02 | hold |
| Ensign Peak Advisors, Inc | 194,200 | 194,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 121 | 121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 10,863 | 10,863 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital International Investors | 2,602,529 | 2,602,529 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Cormorant Asset Management, LP | 2,940,921 | 2,940,921 | 0 | 2.23 | 2.49 | +0.26 | hold |
| Sofinnova Investments, Inc. | 1,995,594 | 1,995,594 | 0 | 1.51 | 1.54 | +0.03 | hold |
| Logos Global Management LP | 208,910 | 208,910 | 0 | 0.37 | 0.32 | -0.06 | hold |
| CATALYST PRIVATE WEALTH, LLC | 10,000 | 10,000 | 0 | 0.05 | 0.05 | +0.00 | hold |
| Nuveen, LLC | 21,873 | 21,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TRV GP VI, LLC | 969,218 | 969,218 | 0 | 23.16 | 17.16 | -6.00 | hold |
| TRV GP V, LLC | 7,135,233 | 7,135,233 | 0 | 57.21 | 48.98 | -8.24 | hold |
| JOHNSON & JOHNSON | 2,498,051 | 2,498,051 | 0 | 7.33 | 8.55 | +1.22 | hold |
| Siren, L.L.C. | 378,469 | 378,469 | 0 | 0.21 | 0.22 | +0.01 | hold |
| Tidemark, LLC | 1,088 | 1,088 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 4,532 | 4,532 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 936 | 936 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,500 | 3,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| STRS OHIO | 1,700 | 1,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 582 | 582 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 7,337 | 7,330 | -7 | 0.01 | 0.01 | +0.00 | sell |
| Allworth Financial LP | 15 | 0 | -15 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 10,554 | 10,535 | -19 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,887 | 9,811 | -76 | 0.00 | 0.00 | +0.00 | sell |
| US BANCORP \DE\ | 144 | 0 | -144 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 8,637 | 8,441 | -196 | 0.02 | 0.03 | +0.01 | sell |
| DEUTSCHE BANK AG\ | 6,502 | 6,249 | -253 | 0.00 | 0.00 | +0.00 | sell |
| GAMMA Investing LLC | 918 | 445 | -473 | 0.00 | 0.00 | -0.00 | sell |
| KLP KAPITALFORVALTNING AS | 1,900 | 0 | -1,900 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 26,128 | 19,712 | -6,416 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 1,115,424 | 1,107,491 | -7,933 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 15,085 | 7,053 | -8,032 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 8,271 | 0 | -8,271 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 10,296 | 1,653 | -8,643 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 1,244,310 | 1,235,035 | -9,275 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 128,083 | 116,273 | -11,810 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 5,486,468 | 5,474,633 | -11,835 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 12,000 | 0 | -12,000 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 13,760 | 0 | -13,760 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 33,757 | 19,743 | -14,014 | 0.00 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 26,830 | 12,594 | -14,236 | 0.01 | 0.01 | -0.01 | sell |
| XTX Topco Ltd | 15,442 | 0 | -15,442 | 0.01 | 0.00 | -0.01 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 29,939 | 1,095 | -28,844 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 31,900 | 0 | -31,900 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 249,414 | 0 | -249,414 | 0.00 | 0.00 | -0.00 | sell |
| Deep Track Capital, LP | 457,556 | 98,237 | -359,319 | 0.15 | 0.04 | -0.11 | sell |
| T. Rowe Price Investment Management, Inc. | 1,551,925 | 613,819 | -938,106 | 0.01 | 0.00 | -0.01 | sell |