| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,168,939 | 7,172,894 | +3,955 | 0.01 | 0.01 | +0.00 | buy |
| TRV GP V, LLC | 7,135,233 | 6,280,525 | -854,708 | 55.68 | 52.53 | -3.15 | sell |
| ARCH Venture Management, LLC | 3,728,738 | 3,728,738 | 0 | 17.23 | 14.12 | -3.11 | hold |
| Capital International Investors | 3,097,973 | 2,921,958 | -176,015 | 0.02 | 0.03 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 2,942,251 | 2,910,449 | -31,802 | 0.01 | 0.01 | +0.00 | sell |
| BlackRock, Inc. | 2,505,955 | 2,699,786 | +193,831 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 2,957,521 | 2,657,521 | -300,000 | 4.67 | 5.67 | +1.01 | sell |
| Sofinnova Investments, Inc. | 1,904,408 | 1,904,408 | 0 | 2.99 | 4.24 | +1.25 | hold |
| JOHNSON & JOHNSON | 1,784,517 | 1,784,517 | 0 | 8.56 | 9.31 | +0.75 | hold |
| Polar Capital Holdings Plc | 1,642,461 | 1,608,514 | -33,947 | 0.22 | 0.19 | -0.03 | sell |
| BAKER BROS. ADVISORS LP | 1,547,090 | 1,547,090 | 0 | 0.28 | 0.32 | +0.05 | hold |
| TRV GP VI, LLC | 969,218 | 969,218 | 0 | 22.37 | 17.39 | -4.98 | hold |
| STATE STREET CORP | 759,552 | 818,712 | +59,160 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 721,622 | 793,453 | +71,831 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 866,456 | 787,446 | -79,010 | 0.00 | 0.00 | +0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 673,923 | 773,342 | +99,419 | 0.42 | 0.50 | +0.08 | buy |
| Vestal Point Capital, LP | 1,436,229 | 730,000 | -706,229 | 1.26 | 0.71 | -0.55 | sell |
| ALLIANCEBERNSTEIN L.P. | 727,843 | 693,384 | -34,459 | 0.01 | 0.01 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 918,866 | 644,082 | -274,784 | 0.01 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 641,469 | 641,469 | 0 | 0.56 | 0.54 | -0.01 | hold |
| Capital World Investors | 536,607 | 551,657 | +15,050 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 620,600 | 393,200 | -227,400 | 0.01 | 0.01 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 224,498 | 362,114 | +137,616 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 185,925 | 347,650 | +161,725 | 0.03 | 0.07 | +0.03 | buy |
| Sio Capital Management, LLC | 366,809 | 307,657 | -59,152 | 1.65 | 2.20 | +0.54 | sell |
| MORGAN STANLEY | 165,954 | 297,612 | +131,658 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 237,992 | 277,305 | +39,313 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 257,431 | 250,795 | -6,636 | 0.17 | 0.19 | +0.01 | sell |
| Burkehill Global Management, LP | 250,000 | 250,000 | 0 | 0.39 | 0.38 | -0.01 | hold |
| Sixth Street Partners Management Company, L.P. | 0 | 246,815 | +246,815 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 239,917 | 246,815 | +6,898 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 0 | 223,822 | +223,822 | 0.00 | 0.11 | +0.11 | buy |
| Invesco Ltd. | 171,757 | 215,236 | +43,479 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 175,449 | 214,831 | +39,382 | 0.00 | 0.01 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 194,200 | 165,546 | -28,654 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 319,552 | 154,908 | -164,644 | 0.01 | 0.00 | -0.00 | sell |
| UBS Group AG | 151,758 | 151,174 | -584 | 0.00 | 0.00 | +0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 150,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Artia Global Partners LP | 138,508 | 138,508 | 0 | 0.98 | 1.10 | +0.12 | hold |
| Swedbank AB | 113,200 | 117,400 | +4,200 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 71,508 | 103,361 | +31,853 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 11,148 | 102,163 | +91,015 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 0 | 97,537 | +97,537 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 99,078 | 91,878 | -7,200 | 0.00 | 0.00 | +0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 78,231 | 86,988 | +8,757 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 114,815 | 86,885 | -27,930 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 0 | 82,442 | +82,442 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 72,319 | 82,222 | +9,903 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 76,616 | +76,616 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 110,826 | 76,076 | -34,750 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 75,000 | 75,000 | 0 | 0.53 | 0.60 | +0.06 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,359 | 69,682 | -5,677 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 66,582 | +66,582 | 0.00 | 0.48 | +0.48 | buy |
| AMERICAN CENTURY COMPANIES INC | 56,292 | 65,764 | +9,472 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 47,903 | 61,441 | +13,538 | 0.03 | 0.03 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 72,948 | 58,537 | -14,411 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 6,868 | 57,468 | +50,600 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 55,705 | +55,705 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 56,500 | 55,200 | -1,300 | 0.00 | 0.00 | +0.00 | sell |
| Russell Investments Group, Ltd. | 32,918 | 55,194 | +22,276 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 20,984 | 53,937 | +32,953 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 38,907 | 48,243 | +9,336 | 0.01 | 0.01 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 22,784 | 39,978 | +17,194 | 0.01 | 0.03 | +0.02 | buy |
| RHUMBLINE ADVISERS | 34,533 | 37,198 | +2,665 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 33,426 | 32,499 | -927 | 0.00 | 0.00 | +0.00 | sell |
| DEUTSCHE BANK AG\ | 24,169 | 32,212 | +8,043 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 11,116 | 32,171 | +21,055 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Quantitative Investments LLC | 0 | 30,386 | +30,386 | 0.00 | 0.21 | +0.21 | buy |
| AQR CAPITAL MANAGEMENT LLC | 25,510 | 26,454 | +944 | 0.00 | 0.00 | +0.00 | buy |
| Ellsworth Advisors, LLC | 0 | 24,539 | +24,539 | 0.00 | 0.16 | +0.16 | buy |
| TWO SIGMA INVESTMENTS, LP | 28,103 | 24,470 | -3,633 | 0.00 | 0.00 | +0.00 | sell |
| CITIGROUP INC | 78,799 | 24,373 | -54,426 | 0.00 | 0.00 | -0.00 | sell |
| Creative Planning | 15,519 | 22,918 | +7,399 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 17,154 | 22,555 | +5,401 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 23,914 | 22,101 | -1,813 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 35,952 | 22,055 | -13,897 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 0 | 21,314 | +21,314 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 35,825 | 19,189 | -16,636 | 0.02 | 0.02 | -0.01 | sell |
| MetLife Investment Management, LLC | 15,996 | 18,009 | +2,013 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 15,846 | 16,564 | +718 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 30,819 | 16,294 | -14,525 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 9,611 | 14,994 | +5,383 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 14,585 | 14,696 | +111 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 14,656 | 14,606 | -50 | 0.23 | 0.22 | -0.01 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 513 | 14,256 | +13,743 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 13,618 | 14,108 | +490 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,058 | 10,812 | -1,246 | 0.03 | 0.03 | -0.00 | sell |
| Allianz Asset Management GmbH | 13,200 | 10,700 | -2,500 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 11,000 | 10,300 | -700 | 0.00 | 0.00 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 6,612 | 10,176 | +3,564 | 0.00 | 0.00 | +0.00 | buy |
| CATALYST PRIVATE WEALTH, LLC | 10,000 | 10,000 | 0 | 0.17 | 0.20 | +0.03 | hold |
| STIFEL FINANCIAL CORP | 9,023 | 9,773 | +750 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,471 | 9,034 | +1,563 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 9,773 | 8,887 | -886 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 9,007 | 8,521 | -486 | 0.08 | 0.08 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 7,035 | 8,371 | +1,336 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 15,672 | 8,255 | -7,417 | 0.00 | 0.00 | -0.00 | sell |
| Arizona State Retirement System | 7,854 | 7,584 | -270 | 0.00 | 0.00 | +0.00 | sell |
| Quadrature Capital Ltd | 0 | 6,359 | +6,359 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 6,358 | +6,358 | 0.00 | 0.01 | +0.01 | buy |