| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| GOLDMAN SACHS GROUP INC | 0 | 1,247,171 | +1,247,171 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 4,983,351 | 5,486,468 | +503,117 | 0.01 | 0.01 | -0.00 | buy |
| VANGUARD GROUP INC | 70,000 | 506,767 | +436,767 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 201,748 | +201,748 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,535,151 | 1,727,111 | +191,960 | 0.02 | 0.02 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 73,146 | +73,146 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 72,212 | +72,212 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 50,000 | 110,401 | +60,401 | 0.02 | 0.04 | +0.02 | buy |
| STATE STREET CORP | 0 | 58,046 | +58,046 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 1,951,562 | 1,995,594 | +44,032 | 2.86 | 3.38 | +0.52 | buy |
| Maven Securities LTD | 0 | 29,930 | +29,930 | 0.00 | 0.07 | +0.07 | buy |
| WINTON GROUP Ltd | 0 | 24,127 | +24,127 | 0.00 | 0.03 | +0.03 | buy |
| Bank of New York Mellon Corp | 0 | 19,970 | +19,970 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 19,110 | +19,110 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 15,843 | +15,843 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 171,100 | 186,560 | +15,460 | 0.04 | 0.03 | -0.01 | buy |
| CITIGROUP INC | 0 | 12,774 | +12,774 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 5,710 | +5,710 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 5,077 | +5,077 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 4,967 | +4,967 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 4,934 | +4,934 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 4,033 | +4,033 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 3,472 | +3,472 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 9,400 | 12,863 | +3,463 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 75,516 | 77,344 | +1,828 | 0.00 | 0.00 | -0.00 | buy |
| STRS OHIO | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,684 | +1,684 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 1,507 | +1,507 | 0.00 | 0.02 | +0.02 | buy |
| Ameritas Investment Partners, Inc. | 0 | 941 | +941 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 909 | +909 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 685 | +685 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 2,940,283 | 2,940,921 | +638 | 3.98 | 3.19 | -0.78 | buy |
| AMALGAMATED BANK | 0 | 317 | +317 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 257 | +257 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 748,183 | 748,183 | 0 | 0.42 | 0.33 | -0.09 | hold |
| ARCH Venture Management, LLC | 3,728,738 | 3,728,738 | 0 | 32.60 | 29.31 | -3.29 | hold |
| NORGES BANK | 70,000 | 70,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Logos Global Management LP | 208,910 | 208,910 | 0 | 0.50 | 0.46 | -0.05 | hold |
| Sandia Investment Management LP | 5,000 | 5,000 | 0 | 0.15 | 0.17 | +0.02 | hold |
| JOHNSON & JOHNSON | 2,498,051 | 2,498,051 | 0 | 14.50 | 11.97 | -2.53 | hold |
| Tidemark, LLC | 1,088 | 1,088 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Capital International Investors | 2,602,531 | 2,602,529 | -2 | 0.01 | 0.01 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,090,858 | 1,088,921 | -1,937 | 0.01 | 0.01 | -0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 20,000 | 17,600 | -2,400 | 0.39 | 0.29 | -0.10 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 13,000 | 0 | -13,000 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 16,345 | 0 | -16,345 | 0.00 | 0.00 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 30,000 | 0 | -30,000 | 0.02 | 0.00 | -0.02 | sell |
| LMR Partners LLP | 50,000 | 20,000 | -30,000 | 0.02 | 0.01 | -0.02 | sell |
| Alyeska Investment Group, L.P. | 34,731 | 0 | -34,731 | 0.00 | 0.00 | -0.00 | sell |
| TD ASSET MANAGEMENT INC | 101,522 | 62,198 | -39,324 | 0.00 | 0.00 | -0.00 | sell |
| Monashee Investment Management LLC | 40,000 | 0 | -40,000 | 0.12 | 0.00 | -0.12 | sell |
| Saturn V Capital Management LP | 70,000 | 0 | -70,000 | 0.62 | 0.00 | -0.62 | sell |
| CITADEL ADVISORS LLC | 592,458 | 487,458 | -105,000 | 0.01 | 0.01 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 116,782 | 0 | -116,782 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,360,605 | 1,047,408 | -313,197 | 0.00 | 0.00 | -0.00 | sell |
| Artal Group S.A. | 350,000 | 0 | -350,000 | 0.21 | 0.00 | -0.21 | sell |