| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TRV GP V, LLC | 7,135,233 | 7,135,233 | 0 | 48.98 | 59.95 | +10.98 | hold |
| FMR LLC | 5,474,633 | 6,916,995 | +1,442,362 | 0.00 | 0.01 | +0.01 | buy |
| ARCH Venture Management, LLC | 3,728,738 | 3,728,738 | 0 | 14.19 | 22.49 | +8.31 | hold |
| Capital International Investors | 2,602,529 | 3,402,529 | +800,000 | 0.01 | 0.02 | +0.01 | buy |
| Cormorant Asset Management, LP | 2,940,921 | 3,192,521 | +251,600 | 2.49 | 6.54 | +4.05 | buy |
| GOLDMAN SACHS GROUP INC | 1,235,035 | 2,421,976 | +1,186,941 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 1,995,594 | 1,947,579 | -48,015 | 1.54 | 3.55 | +2.00 | sell |
| JOHNSON & JOHNSON | 2,498,051 | 1,784,517 | -713,534 | 8.55 | 10.52 | +1.97 | sell |
| VANGUARD GROUP INC | 1,107,491 | 1,626,538 | +519,047 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,219,201 | 1,568,081 | +348,880 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 550,090 | 1,547,090 | +997,000 | 0.06 | 0.33 | +0.27 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,525,519 | 1,102,391 | -423,128 | 0.00 | 0.00 | +0.00 | sell |
| Siren, L.L.C. | 378,469 | 1,053,469 | +675,000 | 0.22 | 1.22 | +1.00 | buy |
| TRV GP VI, LLC | 969,218 | 969,218 | 0 | 17.16 | 26.26 | +9.10 | hold |
| Vestal Point Capital, LP | 0 | 950,000 | +950,000 | 0.00 | 1.28 | +1.28 | buy |
| Polar Capital Holdings Plc | 0 | 938,952 | +938,952 | 0.00 | 0.13 | +0.13 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 243,880 | 892,258 | +648,378 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,154,688 | 855,620 | -299,068 | 0.00 | 0.01 | +0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 613,819 | 707,508 | +93,689 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 273,507 | 558,073 | +284,566 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 333,159 | 533,403 | +200,244 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 450,000 | +450,000 | 0.00 | 0.02 | +0.02 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 403,923 | +403,923 | 0.00 | 0.35 | +0.35 | buy |
| STATE STREET CORP | 298,708 | 371,626 | +72,918 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 274,568 | +274,568 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 250,590 | +250,590 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 250,000 | +250,000 | 0.00 | 0.42 | +0.42 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 203,946 | +203,946 | 0.00 | 0.88 | +0.88 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 93,497 | 202,449 | +108,952 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 194,200 | 194,200 | 0 | 0.00 | 0.01 | +0.01 | hold |
| Sio Capital Management, LLC | 0 | 185,265 | +185,265 | 0.00 | 1.39 | +1.39 | buy |
| Invesco Ltd. | 0 | 157,984 | +157,984 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 157,533 | +157,533 | 0.00 | 1.11 | +1.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 154,174 | +154,174 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 116,273 | 153,857 | +37,584 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 143,565 | +143,565 | 0.00 | 0.33 | +0.33 | buy |
| TD ASSET MANAGEMENT INC | 196,870 | 137,014 | -59,856 | 0.00 | 0.00 | +0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 124,803 | +124,803 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 104,878 | +104,878 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 87,272 | +87,272 | 0.00 | 0.29 | +0.29 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 100,424 | 82,331 | -18,093 | 0.00 | 0.00 | +0.00 | sell |
| Fort Baker Capital Management LP | 0 | 81,644 | +81,644 | 0.00 | 0.40 | +0.40 | buy |
| Soleus Capital Management, L.P. | 0 | 80,000 | +80,000 | 0.00 | 0.13 | +0.13 | buy |
| DAFNA Capital Management LLC | 0 | 75,000 | +75,000 | 0.00 | 0.55 | +0.55 | buy |
| MPM BioImpact LLC | 0 | 71,807 | +71,807 | 0.00 | 0.35 | +0.35 | buy |
| Walleye Capital LLC | 0 | 69,570 | +69,570 | 0.00 | 0.02 | +0.02 | buy |
| Artia Global Partners LP | 0 | 64,608 | +64,608 | 0.00 | 0.34 | +0.34 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 62,822 | +62,822 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 58,061 | +58,061 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 57,148 | +57,148 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 40,104 | 47,422 | +7,318 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 46,223 | +46,223 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 45,130 | +45,130 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 179,860 | 43,480 | -136,380 | 1.35 | 0.80 | -0.55 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 15,600 | 35,300 | +19,700 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,653 | 33,893 | +32,240 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 28,972 | +28,972 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 71,108 | 26,713 | -44,395 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 24,949 | 24,286 | -663 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 21,873 | 21,873 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TWO SIGMA INVESTMENTS, LP | 19,743 | 21,500 | +1,757 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 21,143 | +21,143 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 16,972 | 20,622 | +3,650 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 20,519 | +20,519 | 0.00 | 0.01 | +0.01 | buy |
| Maven Securities LTD | 0 | 20,000 | +20,000 | 0.00 | 0.11 | +0.11 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 18,250 | +18,250 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 19,712 | 17,102 | -2,610 | 0.00 | 0.00 | +0.00 | sell |
| SIMPLEX TRADING, LLC | 0 | 16,730 | +16,730 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 11,267 | 13,462 | +2,195 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 13,341 | +13,341 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 10,602 | 11,959 | +1,357 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 11,330 | +11,330 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 11,149 | +11,149 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,863 | 10,863 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Virtus Investment Advisers, LLC | 8,441 | 10,214 | +1,773 | 0.03 | 0.09 | +0.05 | buy |
| CATALYST PRIVATE WEALTH, LLC | 10,000 | 10,000 | 0 | 0.05 | 0.13 | +0.08 | hold |
| JPMORGAN CHASE & CO | 10,535 | 9,984 | -551 | 0.00 | 0.00 | +0.00 | sell |
| SummitTX Capital, L.P. | 12,594 | 9,830 | -2,764 | 0.01 | 0.01 | +0.01 | sell |
| SEI INVESTMENTS CO | 0 | 8,153 | +8,153 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,811 | 8,053 | -1,758 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 0 | 7,531 | +7,531 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,330 | 7,398 | +68 | 0.01 | 0.02 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,500 | 7,300 | +3,800 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,961 | 7,220 | +5,259 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 6,265 | +6,265 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 6,249 | 6,249 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sandia Investment Management LP | 0 | 6,000 | +6,000 | 0.00 | 0.53 | +0.53 | buy |
| State of Tennessee, Department of Treasury | 0 | 5,400 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,532 | 5,252 | +720 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 4,822 | +4,822 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 4,822 | +4,822 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 3,728 | +3,728 | 0.00 | 0.01 | +0.01 | buy |
| GROUP ONE TRADING LLC | 0 | 2,475 | +2,475 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 1,700 | 2,100 | +400 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 7,053 | 1,770 | -5,283 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,793 | 1,483 | -310 | 0.00 | 0.00 | +0.00 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 1,478 | +1,478 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,304 | 1,458 | +154 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,454 | +1,454 | 0.00 | 0.00 | +0.00 | buy |