| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 1,568,081 | 2,431,862 | +863,781 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 2,421,976 | 3,001,879 | +579,903 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 371,626 | 714,821 | +343,195 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 403,923 | 673,923 | +270,000 | 0.35 | 0.37 | +0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 254,967 | +254,967 | 0.00 | 0.01 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 0 | 247,315 | +247,315 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 6,916,995 | 7,111,865 | +194,870 | 0.01 | 0.01 | +0.00 | buy |
| VANGUARD GROUP INC | 1,626,538 | 1,817,757 | +191,219 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 178,737 | +178,737 | 0.00 | 0.11 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 533,403 | 694,734 | +161,331 | 0.00 | 0.00 | +0.00 | buy |
| Vestal Point Capital, LP | 950,000 | 1,110,000 | +160,000 | 1.28 | 1.24 | -0.04 | buy |
| Swedbank AB | 0 | 113,200 | +113,200 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 157,984 | 267,120 | +109,136 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 35,300 | 118,814 | +83,514 | 0.00 | 0.01 | +0.00 | buy |
| Artia Global Partners LP | 64,608 | 138,508 | +73,900 | 0.34 | 0.68 | +0.34 | buy |
| DIMENSIONAL FUND ADVISORS LP | 11,330 | 83,487 | +72,157 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 153,857 | 220,815 | +66,958 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 938,952 | 1,004,728 | +65,776 | 0.13 | 0.14 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 892,258 | 952,371 | +60,113 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 1,770 | 56,484 | +54,714 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 54,600 | +54,600 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,341 | 66,149 | +52,808 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 21,873 | 70,946 | +49,073 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 154,174 | 201,825 | +47,651 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,478 | 44,291 | +42,813 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 20,519 | 62,979 | +42,460 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 202,449 | 244,391 | +41,942 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 34,651 | +34,651 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 21,500 | 50,619 | +29,119 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 18,250 | 46,849 | +28,599 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 47,422 | 74,081 | +26,659 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 26,713 | 52,480 | +25,767 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,096 | 26,690 | +25,594 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 17,102 | 39,139 | +22,037 | 0.00 | 0.01 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 21,074 | +21,074 | 0.00 | 0.03 | +0.03 | buy |
| WELLS FARGO & COMPANY/MN | 13,462 | 32,109 | +18,647 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 16,783 | +16,783 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 6,249 | 21,535 | +15,286 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 13,800 | +13,800 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 13,200 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 13,062 | +13,062 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,733 | +12,733 | 0.00 | 0.03 | +0.03 | buy |
| SEI INVESTMENTS CO | 8,153 | 18,268 | +10,115 | 0.00 | 0.00 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 9,100 | +9,100 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 8,880 | +8,880 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 8,837 | +8,837 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 8,297 | +8,297 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 8,026 | +8,026 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 7,859 | +7,859 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 7,801 | +7,801 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 7,726 | +7,726 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 7,308 | +7,308 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 0 | 6,823 | +6,823 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 6,690 | +6,690 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 6,594 | +6,594 | 0.00 | 0.01 | +0.01 | buy |
| RHUMBLINE ADVISERS | 24,286 | 30,726 | +6,440 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 5,900 | +5,900 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,053 | 13,249 | +5,196 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 9,984 | 15,129 | +5,145 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,220 | 12,353 | +5,133 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 10,863 | 15,996 | +5,133 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 3,754 | +3,754 | 0.00 | 0.01 | +0.01 | buy |
| SG Americas Securities, LLC | 6,265 | 9,673 | +3,408 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,398 | 10,766 | +3,368 | 0.02 | 0.03 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 5,252 | 7,471 | +2,219 | 0.00 | 0.00 | +0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 0 | 1,208 | +1,208 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,411 | 2,316 | +905 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,454 | 2,282 | +828 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,483 | 2,310 | +827 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 1,211 | 1,640 | +429 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 420 | +420 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 582 | 894 | +312 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 300 | +300 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 20,622 | 20,878 | +256 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 11,959 | 12,212 | +253 | 0.00 | 0.00 | -0.00 | buy |
| MassMutual Private Wealth & Trust, FSB | 0 | 161 | +161 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 789 | 935 | +146 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 83 | +83 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 205 | 225 | +20 | 0.00 | 0.00 | +0.00 | buy |
| SageView Advisory Group, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,458 | 1,468 | +10 | 0.00 | 0.00 | -0.00 | buy |
| SBI Securities Co., Ltd. | 53 | 63 | +10 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 1,547,090 | 1,547,090 | 0 | 0.33 | 0.27 | -0.06 | hold |
| ARCH Venture Management, LLC | 3,728,738 | 3,728,738 | 0 | 22.49 | 17.36 | -5.13 | hold |
| DAFNA Capital Management LLC | 75,000 | 75,000 | 0 | 0.55 | 0.53 | -0.02 | hold |
| Ensign Peak Advisors, Inc | 194,200 | 194,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Daiwa Securities Group Inc. | 121 | 121 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sio Capital Management, LLC | 185,265 | 185,265 | 0 | 1.39 | 0.93 | -0.46 | hold |
| Capital International Investors | 3,402,529 | 3,402,529 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Sunbelt Securities, Inc. | 11 | 11 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 3 | 3 | 0 | 0.00 | 0.00 | -0.00 | hold |
| QUADRANT CAPITAL GROUP LLC | 57 | 57 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 115 | 115 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CATALYST PRIVATE WEALTH, LLC | 10,000 | 10,000 | 0 | 0.13 | 0.13 | +0.00 | hold |
| Sandia Investment Management LP | 6,000 | 6,000 | 0 | 0.53 | 0.45 | -0.08 | hold |
| Burkehill Global Management, LP | 250,000 | 250,000 | 0 | 0.42 | 0.50 | +0.08 | hold |
| True Wealth Design, LLC | 44 | 44 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TRV GP VI, LLC | 969,218 | 969,218 | 0 | 26.26 | 19.80 | -6.46 | hold |