| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TRV GP V, LLC | 7,135,233 | 7,135,233 | 0 | 59.95 | 50.44 | -9.51 | hold |
| FMR LLC | 6,916,995 | 7,111,865 | +194,870 | 0.01 | 0.01 | +0.00 | buy |
| ARCH Venture Management, LLC | 3,728,738 | 3,728,738 | 0 | 22.49 | 17.36 | -5.13 | hold |
| Capital International Investors | 3,402,529 | 3,402,529 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Cormorant Asset Management, LP | 3,192,521 | 3,027,521 | -165,000 | 6.54 | 5.21 | -1.34 | sell |
| GOLDMAN SACHS GROUP INC | 2,421,976 | 3,001,879 | +579,903 | 0.01 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 1,568,081 | 2,431,862 | +863,781 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 1,947,579 | 1,904,408 | -43,171 | 3.55 | 2.49 | -1.06 | sell |
| VANGUARD GROUP INC | 1,626,538 | 1,817,757 | +191,219 | 0.00 | 0.00 | +0.00 | buy |
| JOHNSON & JOHNSON | 1,784,517 | 1,784,517 | 0 | 10.52 | 9.75 | -0.76 | hold |
| BAKER BROS. ADVISORS LP | 1,547,090 | 1,547,090 | 0 | 0.33 | 0.27 | -0.06 | hold |
| Vestal Point Capital, LP | 950,000 | 1,110,000 | +160,000 | 1.28 | 1.24 | -0.04 | buy |
| Polar Capital Holdings Plc | 938,952 | 1,004,728 | +65,776 | 0.13 | 0.14 | +0.00 | buy |
| TRV GP VI, LLC | 969,218 | 969,218 | 0 | 26.26 | 19.80 | -6.46 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 892,258 | 952,371 | +60,113 | 0.01 | 0.01 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,102,391 | 881,609 | -220,782 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 855,620 | 788,411 | -67,209 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 371,626 | 714,821 | +343,195 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 1,053,469 | 708,469 | -345,000 | 1.22 | 0.64 | -0.58 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 533,403 | 694,734 | +161,331 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 403,923 | 673,923 | +270,000 | 0.35 | 0.37 | +0.03 | buy |
| T. Rowe Price Investment Management, Inc. | 707,508 | 619,029 | -88,479 | 0.01 | 0.01 | -0.00 | sell |
| Invesco Ltd. | 157,984 | 267,120 | +109,136 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 254,967 | +254,967 | 0.00 | 0.01 | +0.01 | buy |
| Burkehill Global Management, LP | 250,000 | 250,000 | 0 | 0.42 | 0.50 | +0.08 | hold |
| D. E. Shaw & Co., Inc. | 0 | 247,315 | +247,315 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 202,449 | 244,391 | +41,942 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 558,073 | 226,360 | -331,713 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 153,857 | 220,815 | +66,958 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 274,568 | 210,331 | -64,237 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 154,174 | 201,825 | +47,651 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 194,200 | 194,200 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Sio Capital Management, LLC | 185,265 | 185,265 | 0 | 1.39 | 0.93 | -0.46 | hold |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 178,737 | +178,737 | 0.00 | 0.11 | +0.11 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 450,000 | 150,000 | -300,000 | 0.02 | 0.01 | -0.01 | sell |
| Artia Global Partners LP | 64,608 | 138,508 | +73,900 | 0.34 | 0.68 | +0.34 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 35,300 | 118,814 | +83,514 | 0.00 | 0.01 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 137,014 | 115,190 | -21,824 | 0.00 | 0.00 | -0.00 | sell |
| Swedbank AB | 0 | 113,200 | +113,200 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 87,272 | 85,555 | -1,717 | 0.29 | 0.29 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 11,330 | 83,487 | +72,157 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 82,331 | 78,659 | -3,672 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 75,000 | 75,000 | 0 | 0.55 | 0.53 | -0.02 | hold |
| Bank of New York Mellon Corp | 47,422 | 74,081 | +26,659 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 21,873 | 70,946 | +49,073 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 13,341 | 66,149 | +52,808 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 20,519 | 62,979 | +42,460 | 0.01 | 0.02 | +0.01 | buy |
| Eversept Partners, LP | 143,565 | 59,233 | -84,332 | 0.33 | 0.10 | -0.23 | sell |
| CITIGROUP INC | 1,770 | 56,484 | +54,714 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 62,822 | 56,457 | -6,365 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 0 | 54,600 | +54,600 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 26,713 | 52,480 | +25,767 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 21,500 | 50,619 | +29,119 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 18,250 | 46,849 | +28,599 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 1,478 | 44,291 | +42,813 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 17,102 | 39,139 | +22,037 | 0.00 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 43,480 | 38,925 | -4,555 | 0.80 | 0.95 | +0.15 | sell |
| ExodusPoint Capital Management, LP | 0 | 34,651 | +34,651 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 58,061 | 34,553 | -23,508 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 13,462 | 32,109 | +18,647 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 24,286 | 30,726 | +6,440 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,096 | 26,690 | +25,594 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 33,893 | 22,384 | -11,509 | 0.00 | 0.00 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 6,249 | 21,535 | +15,286 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 21,074 | +21,074 | 0.00 | 0.03 | +0.03 | buy |
| AQR CAPITAL MANAGEMENT LLC | 20,622 | 20,878 | +256 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 8,153 | 18,268 | +10,115 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 16,783 | +16,783 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 10,863 | 15,996 | +5,133 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 9,984 | 15,129 | +5,145 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 124,803 | 14,794 | -110,009 | 0.00 | 0.00 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 0 | 13,800 | +13,800 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,053 | 13,249 | +5,196 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 0 | 13,200 | +13,200 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 13,062 | +13,062 | 0.00 | 0.01 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 12,733 | +12,733 | 0.00 | 0.03 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,220 | 12,353 | +5,133 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,959 | 12,212 | +253 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,398 | 10,766 | +3,368 | 0.02 | 0.03 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 21,143 | 10,208 | -10,935 | 0.00 | 0.00 | -0.00 | sell |
| CATALYST PRIVATE WEALTH, LLC | 10,000 | 10,000 | 0 | 0.13 | 0.13 | +0.00 | hold |
| SG Americas Securities, LLC | 6,265 | 9,673 | +3,408 | 0.00 | 0.00 | -0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 203,946 | 9,659 | -194,287 | 0.88 | 0.04 | -0.83 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 9,100 | +9,100 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 8,880 | +8,880 | 0.00 | 0.01 | +0.01 | buy |
| Quadrature Capital Ltd | 0 | 8,837 | +8,837 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 10,214 | 8,789 | -1,425 | 0.09 | 0.07 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 8,297 | +8,297 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 104,878 | 8,099 | -96,779 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 8,026 | +8,026 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 7,859 | +7,859 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 7,801 | +7,801 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 0 | 7,726 | +7,726 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 5,252 | 7,471 | +2,219 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 7,308 | +7,308 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 7,300 | 7,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 7,531 | 7,031 | -500 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 0 | 6,823 | +6,823 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 6,690 | +6,690 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 6,594 | +6,594 | 0.00 | 0.01 | +0.01 | buy |