| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PERCEPTIVE ADVISORS LLC | 403,923 | 673,923 | +270,000 | 0.35 | 0.36 | +0.02 | buy |
| Vestal Point Capital, LP | 950,000 | 1,110,000 | +160,000 | 1.28 | 1.24 | -0.04 | buy |
| Artia Global Partners LP | 64,608 | 138,508 | +73,900 | 0.34 | 0.68 | +0.34 | buy |
| Polar Capital Holdings Plc | 938,952 | 1,004,728 | +65,776 | 0.13 | 0.14 | +0.00 | buy |
| ALPS ADVISORS INC | 17,102 | 39,139 | +22,037 | 0.00 | 0.01 | 0.00 | buy |
| China Universal Asset Management Co., Ltd. | 7,398 | 10,766 | +3,368 | 0.02 | 0.03 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 789 | 935 | +146 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 7,531 | 7,031 | -500 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 10,214 | 8,789 | -1,425 | 0.09 | 0.07 | -0.01 | sell |
| Informed Momentum Co LLC | 87,272 | 85,555 | -1,717 | 0.29 | 0.29 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 43,480 | 38,925 | -4,555 | 0.80 | 0.95 | +0.15 | sell |
| TD ASSET MANAGEMENT INC | 137,014 | 115,190 | -21,824 | 0.00 | 0.00 | -0.00 | sell |
| Sofinnova Investments, Inc. | 1,947,579 | 1,904,408 | -43,171 | 3.16 | 2.49 | -0.67 | sell |
| Eversept Partners, LP | 143,565 | 59,233 | -84,332 | 0.29 | 0.09 | -0.20 | sell |
| T. Rowe Price Investment Management, Inc. | 707,508 | 619,029 | -88,479 | 0.01 | 0.01 | -0.00 | sell |
| Cormorant Asset Management, LP | 3,192,521 | 3,027,521 | -165,000 | 6.54 | 4.25 | -2.30 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 203,946 | 9,659 | -194,287 | 0.88 | 0.04 | -0.83 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,102,391 | 881,609 | -220,782 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 450,000 | 150,000 | -300,000 | 0.02 | 0.01 | -0.01 | sell |
| Siren, L.L.C. | 1,053,469 | 708,469 | -345,000 | 1.22 | 0.64 | -0.58 | sell |