| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 14,217,768 | 30,785,585 | +16,567,817 | 0.02 | 0.03 | +0.01 | buy |
| Sixth Street Partners Management Company, L.P. | 19,385,399 | 14,385,399 | -5,000,000 | 53.72 | 36.19 | -17.53 | sell |
| COATUE MANAGEMENT LLC | 9,819,992 | 9,819,992 | 0 | 0.66 | 0.60 | -0.06 | hold |
| BRAIDWELL LP | 7,816,142 | 8,009,447 | +193,305 | 6.74 | 4.78 | -1.97 | buy |
| PointState Capital LP | 6,718,707 | 7,360,446 | +641,739 | 3.10 | 3.06 | -0.04 | buy |
| T. Rowe Price Investment Management, Inc. | 9,205,959 | 5,588,257 | -3,617,702 | 0.16 | 0.07 | -0.09 | sell |
| BlackRock, Inc. | 2,371,236 | 4,857,112 | +2,485,876 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,827,965 | 4,371,771 | -456,194 | 0.01 | 0.01 | -0.01 | sell |
| Neuberger Berman Group LLC | 3,800,922 | 3,590,586 | -210,336 | 0.08 | 0.05 | -0.03 | sell |
| JPMORGAN CHASE & CO | 2,445,281 | 3,460,215 | +1,014,934 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 3,116,011 | 2,806,811 | -309,200 | 1.72 | 1.09 | -0.63 | sell |
| UBS Group AG | 2,183,980 | 2,745,811 | +561,831 | 0.01 | 0.01 | -0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 565 | 2,289,602 | +2,289,037 | 0.00 | 0.16 | +0.16 | buy |
| Duquesne Family Office LLC | 0 | 1,894,450 | +1,894,450 | 0.00 | 1.15 | +1.15 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 685,826 | 1,614,286 | +928,460 | 0.01 | 0.02 | +0.01 | buy |
| Clearbridge Investments, LLC | 1,416,207 | 1,551,774 | +135,567 | 0.03 | 0.02 | -0.01 | buy |
| FIL Ltd | 1,122,775 | 1,546,091 | +423,316 | 0.02 | 0.02 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 3,652,647 | 1,527,756 | -2,124,891 | 0.07 | 0.02 | -0.05 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,464,558 | 1,322,752 | -141,806 | 0.03 | 0.02 | -0.01 | sell |
| Invesco Ltd. | 1,033,115 | 1,222,278 | +189,163 | 0.00 | 0.00 | -0.00 | buy |
| Champlain Investment Partners, LLC | 939,365 | 1,207,963 | +268,598 | 0.26 | 0.27 | +0.02 | buy |
| Capital World Investors | 0 | 1,180,173 | +1,180,173 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,470,295 | 1,149,133 | -321,162 | 0.01 | 0.00 | -0.00 | sell |
| MORGAN STANLEY | 1,794,991 | 1,079,417 | -715,574 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 260,645 | 984,953 | +724,308 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 1,864,860 | 918,331 | -946,529 | 0.08 | 0.03 | -0.05 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 372,979 | 778,532 | +405,553 | 0.00 | 0.00 | +0.00 | buy |
| Gotham Asset Management, LLC | 67,186 | 744,426 | +677,240 | 0.01 | 0.04 | +0.03 | buy |
| Woodline Partners LP | 723,163 | 723,163 | 0 | 0.08 | 0.05 | -0.03 | hold |
| TD ASSET MANAGEMENT INC | 773,852 | 670,388 | -103,464 | 0.02 | 0.01 | -0.01 | sell |
| Nuveen, LLC | 22,413 | 663,578 | +641,165 | 0.00 | 0.00 | +0.00 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 543,185 | 610,233 | +67,048 | 0.33 | 0.31 | -0.01 | buy |
| SEI INVESTMENTS CO | 24,451 | 598,712 | +574,261 | 0.00 | 0.01 | +0.01 | buy |
| Rock Springs Capital Management LP | 687,500 | 563,000 | -124,500 | 0.95 | 0.59 | -0.36 | sell |
| BANK OF AMERICA CORP /DE/ | 1,122,748 | 523,268 | -599,480 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 82,705 | 490,536 | +407,831 | 0.02 | 0.06 | +0.04 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 329,900 | 449,900 | +120,000 | 0.01 | 0.01 | -0.00 | buy |
| GOLDMAN SACHS GROUP INC | 350,142 | 410,340 | +60,198 | 0.00 | 0.00 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 1,505,080 | 408,079 | -1,097,001 | 0.01 | 0.00 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 242,779 | 305,911 | +63,132 | 0.01 | 0.01 | -0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 218,305 | 278,977 | +60,672 | 0.06 | 0.05 | -0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 941,639 | 267,950 | -673,689 | 0.01 | 0.00 | -0.01 | sell |
| Ghisallo Capital Management LLC | 845,332 | 250,000 | -595,332 | 1.02 | 0.12 | -0.90 | sell |
| FEDERATED HERMES, INC. | 3,000 | 239,150 | +236,150 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 50,403 | 231,661 | +181,258 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 125,000 | 229,912 | +104,912 | 0.32 | 0.43 | +0.11 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 210,593 | +210,593 | 0.00 | 0.00 | +0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 188,861 | 194,710 | +5,849 | 0.02 | 0.01 | -0.01 | buy |
| Qube Research & Technologies Ltd | 206,993 | 187,480 | -19,513 | 0.01 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 36,948 | 174,065 | +137,117 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 101,816 | 153,512 | +51,696 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 146,100 | 146,100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Quantinno Capital Management LP | 64,922 | 140,909 | +75,987 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 3,817 | 140,097 | +136,280 | 0.00 | 0.07 | +0.07 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 150,000 | 136,334 | -13,666 | 0.01 | 0.01 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 0 | 129,577 | +129,577 | 0.00 | 0.00 | +0.00 | buy |
| Man Group plc | 0 | 128,971 | +128,971 | 0.00 | 0.00 | +0.00 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 162,313 | 109,539 | -52,774 | 0.16 | 0.08 | -0.09 | sell |
| Engineers Gate Manager LP | 71,403 | 102,757 | +31,354 | 0.02 | 0.02 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 182,382 | 100,327 | -82,055 | 0.03 | 0.01 | -0.02 | sell |
| Smartleaf Asset Management LLC | 0 | 94,051 | +94,051 | 0.00 | 0.06 | +0.06 | buy |
| RAYMOND JAMES FINANCIAL INC | 97,518 | 90,233 | -7,285 | 0.00 | 0.00 | -0.00 | sell |
| PURA VIDA INVESTMENTS, LLC | 89,940 | 89,940 | 0 | 9.07 | 10.81 | +1.74 | hold |
| XTX Topco Ltd | 0 | 78,506 | +78,506 | 0.00 | 0.02 | +0.02 | buy |
| Creative Planning | 149,856 | 77,998 | -71,858 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 3,113,956 | 77,810 | -3,036,146 | 0.06 | 0.00 | -0.06 | sell |
| CITIGROUP INC | 30,725 | 77,180 | +46,455 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 75,000 | 75,000 | 0 | 0.13 | 0.07 | -0.07 | hold |
| RHUMBLINE ADVISERS | 23,381 | 74,622 | +51,241 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 54,117 | 74,423 | +20,306 | 0.00 | 0.00 | -0.00 | buy |
| TWINBEECH CAPITAL LP | 0 | 58,100 | +58,100 | 0.00 | 0.11 | +0.11 | buy |
| ALLIANCEBERNSTEIN L.P. | 20,387 | 57,076 | +36,689 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 75,330 | 56,744 | -18,586 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 31,029 | 53,607 | +22,578 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 53,066 | +53,066 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 52,778 | +52,778 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 45,976 | 50,069 | +4,093 | 0.10 | 0.07 | -0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 12,900 | 45,700 | +32,800 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 268,615 | 44,975 | -223,640 | 0.00 | 0.00 | -0.00 | sell |
| Renaissance Capital LLC | 14,429 | 43,484 | +29,055 | 0.28 | 0.60 | +0.32 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 78,163 | 43,080 | -35,083 | 0.10 | 0.07 | -0.03 | sell |
| LPL Financial LLC | 25,711 | 42,041 | +16,330 | 0.00 | 0.00 | +0.00 | buy |
| CastleKnight Management LP | 10,436 | 41,036 | +30,600 | 0.02 | 0.03 | +0.02 | buy |
| Entropy Technologies, LP | 0 | 40,503 | +40,503 | 0.00 | 0.03 | +0.03 | buy |
| Police & Firemen's Retirement System of New Jersey | 11,932 | 39,497 | +27,565 | 0.00 | 0.01 | +0.00 | buy |
| Treasurer of the State of North Carolina | 9,496 | 39,005 | +29,509 | 0.00 | 0.00 | +0.00 | buy |
| Americana Partners, LLC | 12,433 | 38,367 | +25,934 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 25,290 | 38,290 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| Nikko Asset Management Americas, Inc. | 54,719 | 36,133 | -18,586 | 0.02 | 0.01 | -0.01 | sell |
| Caption Management, LLC | 50,888 | 33,332 | -17,556 | 0.06 | 0.03 | -0.03 | sell |
| Diversified Trust Co | 20,000 | 32,500 | +12,500 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,157 | 30,350 | +193 | 0.00 | 0.00 | -0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 28,994 | +28,994 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 6,881 | 28,781 | +21,900 | 0.00 | 0.00 | +0.00 | buy |
| PARK AVENUE SECURITIES LLC | 0 | 27,937 | +27,937 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 0 | 27,492 | +27,492 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 6,821 | 26,519 | +19,698 | 0.00 | 0.00 | +0.00 | buy |
| OAK RIDGE INVESTMENTS LLC | 21,820 | 26,106 | +4,286 | 0.04 | 0.03 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 25,331 | +25,331 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,995 | 25,269 | +23,274 | 0.00 | 0.00 | +0.00 | buy |