| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 30,785,585 | 30,923,878 | +138,293 | 0.03 | 0.02 | -0.01 | buy |
| COATUE MANAGEMENT LLC | 9,819,992 | 9,819,992 | 0 | 0.60 | 0.36 | -0.24 | hold |
| BRAIDWELL LP | 8,009,447 | 8,256,032 | +246,585 | 4.78 | 5.44 | +0.66 | buy |
| Sixth Street Partners Management Company, L.P. | 14,385,399 | 7,327,041 | -7,058,358 | 36.19 | 0.02 | -36.17 | sell |
| PointState Capital LP | 7,360,446 | 6,828,835 | -531,611 | 3.06 | 2.14 | -0.91 | sell |
| JPMORGAN CHASE & CO | 3,460,215 | 6,558,514 | +3,098,299 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 4,857,112 | 5,536,798 | +679,686 | 0.00 | 0.00 | -0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 5,588,257 | 5,079,141 | -509,116 | 0.07 | 0.06 | -0.01 | sell |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 2,289,602 | 3,958,531 | +1,668,929 | 0.16 | 0.26 | +0.10 | buy |
| Neuberger Berman Group LLC | 3,590,586 | 3,590,963 | +377 | 0.05 | 0.04 | -0.01 | buy |
| ORBIMED ADVISORS LLC | 2,806,811 | 2,806,811 | 0 | 1.09 | 0.95 | -0.15 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 1,614,286 | 2,370,268 | +755,982 | 0.02 | 0.02 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,527,756 | 2,202,647 | +674,891 | 0.02 | 0.03 | +0.01 | buy |
| MAK CAPITAL ONE LLC | 0 | 1,937,229 | +1,937,229 | 0.00 | 4.84 | +4.84 | buy |
| MORGAN STANLEY | 1,079,417 | 1,935,531 | +856,114 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 1,894,450 | 1,894,450 | 0 | 1.15 | 0.78 | -0.38 | hold |
| Clearbridge Investments, LLC | 1,551,774 | 1,595,877 | +44,103 | 0.02 | 0.02 | -0.00 | buy |
| FIL Ltd | 1,546,091 | 1,548,918 | +2,827 | 0.02 | 0.02 | -0.00 | buy |
| UBS Group AG | 2,745,811 | 1,423,371 | -1,322,440 | 0.01 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 0 | 1,418,392 | +1,418,392 | 0.00 | 0.05 | +0.05 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,322,752 | 1,374,952 | +52,200 | 0.02 | 0.01 | -0.00 | buy |
| Amundi | 20,972 | 1,218,364 | +1,197,392 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 984,953 | 1,217,548 | +232,595 | 0.00 | 0.00 | +0.00 | buy |
| Capital World Investors | 1,180,173 | 1,213,272 | +33,099 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 4,371,771 | 1,205,390 | -3,166,381 | 0.01 | 0.00 | -0.01 | sell |
| BANK OF AMERICA CORP /DE/ | 523,268 | 1,200,590 | +677,322 | 0.00 | 0.00 | +0.00 | buy |
| Champlain Investment Partners, LLC | 1,207,963 | 1,048,862 | -159,101 | 0.27 | 0.48 | +0.21 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 778,532 | 1,044,657 | +266,125 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 410,340 | 951,942 | +541,602 | 0.00 | 0.00 | +0.00 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 610,233 | 802,083 | +191,850 | 0.31 | 0.33 | +0.01 | buy |
| SEI INVESTMENTS CO | 598,712 | 762,659 | +163,947 | 0.01 | 0.01 | +0.00 | buy |
| Trexquant Investment LP | 490,536 | 727,944 | +237,408 | 0.06 | 0.08 | +0.02 | buy |
| Woodline Partners LP | 723,163 | 723,163 | 0 | 0.05 | 0.04 | -0.01 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 210,593 | 655,644 | +445,051 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 663,578 | 604,416 | -59,162 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 408,079 | 572,784 | +164,705 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 449,900 | 568,000 | +118,100 | 0.01 | 0.01 | +0.00 | buy |
| Rock Springs Capital Management LP | 563,000 | 487,500 | -75,500 | 0.59 | 0.42 | -0.17 | sell |
| Quantinno Capital Management LP | 140,909 | 441,672 | +300,763 | 0.00 | 0.01 | +0.01 | buy |
| Walleye Capital LLC | 0 | 424,407 | +424,407 | 0.00 | 0.04 | +0.04 | buy |
| Squarepoint Ops LLC | 0 | 380,927 | +380,927 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 670,388 | 379,388 | -291,000 | 0.01 | 0.01 | -0.00 | sell |
| Bank of New York Mellon Corp | 231,661 | 308,407 | +76,746 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 77,810 | 297,855 | +220,045 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 239,150 | 285,598 | +46,448 | 0.01 | 0.01 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 278,977 | 264,064 | -14,913 | 0.05 | 0.04 | -0.01 | sell |
| NORTHERN TRUST CORP | 174,065 | 258,787 | +84,722 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 187,480 | 226,878 | +39,398 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 0 | 222,717 | +222,717 | 0.00 | 0.00 | +0.00 | buy |
| Maxi Investments CY Ltd | 0 | 210,670 | +210,670 | 0.00 | 0.76 | +0.76 | buy |
| D. E. Shaw & Co., Inc. | 129,577 | 204,818 | +75,241 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 53,066 | 204,432 | +151,366 | 0.00 | 0.00 | +0.00 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 194,710 | 204,152 | +9,442 | 0.01 | 0.01 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 5,002 | 182,345 | +177,343 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 30,350 | 173,010 | +142,660 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 152,236 | +152,236 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 146,100 | 146,100 | 0 | 0.00 | 0.00 | 0.00 | hold |
| XTX Topco Ltd | 78,506 | 136,488 | +57,982 | 0.02 | 0.03 | +0.01 | buy |
| CastleKnight Management LP | 41,036 | 132,236 | +91,200 | 0.03 | 0.09 | +0.05 | buy |
| Invesco Ltd. | 1,222,278 | 132,103 | -1,090,175 | 0.00 | 0.00 | -0.00 | sell |
| NATIXIS | 52,778 | 124,716 | +71,938 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 136,334 | 123,129 | -13,205 | 0.01 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 77,180 | 111,236 | +34,056 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 18,651 | 102,044 | +83,393 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 100,327 | 100,327 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Ghisallo Capital Management LLC | 250,000 | 100,000 | -150,000 | 0.12 | 0.03 | -0.09 | sell |
| SALEM INVESTMENT COUNSELORS INC | 0 | 100,000 | +100,000 | 0.00 | 0.04 | +0.04 | buy |
| RHUMBLINE ADVISERS | 74,622 | 98,849 | +24,227 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 90,233 | 98,595 | +8,362 | 0.00 | 0.00 | -0.00 | buy |
| Smartleaf Asset Management LLC | 94,051 | 94,051 | 0 | 0.06 | 0.06 | -0.00 | hold |
| Gotham Asset Management, LLC | 744,426 | 89,535 | -654,891 | 0.04 | 0.00 | -0.04 | sell |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 85,600 | +85,600 | 0.00 | 0.00 | +0.00 | buy |
| Pathstone Holdings, LLC | 0 | 82,782 | +82,782 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 305,911 | 81,736 | -224,175 | 0.01 | 0.00 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 57,076 | 81,021 | +23,945 | 0.00 | 0.00 | -0.00 | buy |
| Exome Asset Management LLC | 0 | 78,180 | +78,180 | 0.00 | 0.86 | +0.86 | buy |
| Creative Planning | 77,998 | 77,456 | -542 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 53,607 | 71,695 | +18,088 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 68,222 | +68,222 | 0.00 | 0.01 | +0.01 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 63,895 | +63,895 | 0.00 | 0.03 | +0.03 | buy |
| Renaissance Capital LLC | 43,484 | 62,887 | +19,403 | 0.60 | 0.62 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 45,700 | 61,300 | +15,600 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 12,296 | 61,237 | +48,941 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 59,873 | +59,873 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 28,994 | 59,103 | +30,109 | 0.00 | 0.00 | +0.00 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 56,744 | 54,890 | -1,854 | 0.00 | 0.00 | -0.00 | sell |
| Police & Firemen's Retirement System of New Jersey | 39,497 | 54,057 | +14,560 | 0.01 | 0.01 | +0.00 | buy |
| Treasurer of the State of North Carolina | 39,005 | 52,515 | +13,510 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 42,041 | 51,502 | +9,461 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS ADVISORS, LLC | 13,759 | 49,587 | +35,828 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 153,512 | 47,595 | -105,917 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 46,068 | +46,068 | 0.00 | 0.02 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 50,069 | 44,989 | -5,080 | 0.07 | 0.05 | -0.02 | sell |
| Virtu Financial LLC | 0 | 44,018 | +44,018 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 38,290 | 43,653 | +5,363 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 14,940 | 42,899 | +27,959 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 25,331 | 42,500 | +17,169 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 25,269 | 41,316 | +16,047 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 74,423 | 41,228 | -33,195 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 38,493 | +38,493 | 0.00 | 0.01 | +0.01 | buy |