| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sixth Street Partners Management Company, L.P. | 24,385,399 | 19,385,399 | -5,000,000 | 63.36 | 53.72 | -9.64 | sell |
| FMR LLC | 9,633,435 | 14,217,768 | +4,584,333 | 0.02 | 0.02 | +0.00 | buy |
| COATUE MANAGEMENT LLC | 10,142,198 | 9,819,992 | -322,206 | 0.75 | 0.66 | -0.09 | sell |
| T. Rowe Price Investment Management, Inc. | 8,025,759 | 9,205,959 | +1,180,200 | 0.15 | 0.16 | +0.01 | buy |
| BRAIDWELL LP | 7,316,142 | 7,816,142 | +500,000 | 6.57 | 6.74 | +0.18 | buy |
| PointState Capital LP | 3,883,721 | 6,718,707 | +2,834,986 | 2.11 | 3.10 | +0.99 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 6,924,745 | 4,827,965 | -2,096,780 | 0.02 | 0.01 | -0.01 | sell |
| Neuberger Berman Group LLC | 4,345,042 | 3,800,922 | -544,120 | 0.08 | 0.08 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 3,938,072 | 3,652,647 | -285,425 | 0.09 | 0.07 | -0.02 | sell |
| ORBIMED ADVISORS LLC | 3,034,858 | 3,116,011 | +81,153 | 2.20 | 1.72 | -0.48 | buy |
| CITADEL ADVISORS LLC | 0 | 3,113,956 | +3,113,956 | 0.00 | 0.06 | +0.06 | buy |
| JPMORGAN CHASE & CO | 858,105 | 2,445,281 | +1,587,176 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 647,081 | 2,371,236 | +1,724,155 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 235,873 | 2,183,980 | +1,948,107 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 246,624 | 1,864,860 | +1,618,236 | 0.02 | 0.08 | +0.06 | buy |
| MORGAN STANLEY | 1,534,423 | 1,794,991 | +260,568 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 6,917 | 1,660,280 | +1,653,363 | 0.00 | 0.08 | +0.08 | buy |
| Longaeva Partners L.P. | 1,285,968 | 1,509,745 | +223,777 | 8.27 | 4.84 | -3.43 | buy |
| AMERIPRISE FINANCIAL INC | 1,679,468 | 1,505,080 | -174,388 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,116,191 | 1,470,295 | +354,104 | 0.01 | 0.01 | +0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,322,752 | 1,464,558 | +141,806 | 0.03 | 0.03 | -0.00 | buy |
| Clearbridge Investments, LLC | 1,381,230 | 1,416,207 | +34,977 | 0.03 | 0.03 | -0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,098,163 | 1,136,206 | +38,043 | 0.96 | 0.56 | -0.40 | buy |
| FIL Ltd | 225,920 | 1,122,775 | +896,855 | 0.01 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 429,478 | 1,122,748 | +693,270 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 803,802 | 1,033,115 | +229,313 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 82,975 | 1,002,734 | +919,759 | 0.00 | 0.03 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 971,330 | 941,639 | -29,691 | 0.01 | 0.01 | -0.00 | sell |
| Champlain Investment Partners, LLC | 0 | 939,365 | +939,365 | 0.00 | 0.26 | +0.26 | buy |
| Ghisallo Capital Management LLC | 1,048,163 | 845,332 | -202,831 | 1.04 | 1.02 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 222,336 | 773,852 | +551,516 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 723,163 | 723,163 | 0 | 0.10 | 0.08 | -0.03 | hold |
| Rock Springs Capital Management LP | 793,651 | 687,500 | -106,151 | 1.40 | 0.95 | -0.45 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,200 | 685,826 | +684,626 | 0.00 | 0.01 | +0.01 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 0 | 543,185 | +543,185 | 0.00 | 0.33 | +0.33 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 495,095 | +395,095 | 0.25 | 1.02 | +0.77 | buy |
| ARK Investment Management LLC | 245,350 | 408,725 | +163,375 | 0.04 | 0.07 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 398,328 | 372,979 | -25,349 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 282,209 | 350,142 | +67,933 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 225,100 | 329,900 | +104,800 | 0.01 | 0.01 | +0.00 | buy |
| Meridiem Capital Partners LP | 0 | 278,063 | +278,063 | 0.00 | 0.47 | +0.47 | buy |
| FRANKLIN RESOURCES INC | 216,964 | 268,615 | +51,651 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 155,340 | 260,645 | +105,305 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 247,407 | +247,407 | 0.00 | 0.03 | +0.03 | buy |
| LAZARD ASSET MANAGEMENT LLC | 277,537 | 242,779 | -34,758 | 0.01 | 0.01 | -0.00 | sell |
| Holocene Advisors, LP | 171,127 | 237,897 | +66,770 | 0.01 | 0.01 | +0.00 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 6,210 | 218,305 | +212,095 | 0.00 | 0.06 | +0.06 | buy |
| Qube Research & Technologies Ltd | 32,752 | 206,993 | +174,241 | 0.00 | 0.01 | +0.01 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 10,092 | 188,861 | +178,769 | 0.00 | 0.02 | +0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 264,551 | 182,382 | -82,169 | 0.05 | 0.03 | -0.02 | sell |
| JANE STREET GROUP, LLC | 14,595 | 170,997 | +156,402 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 320,669 | 162,915 | -157,754 | 0.08 | 0.03 | -0.05 | sell |
| ODDO BHF ASSET MANAGEMENT SAS | 0 | 162,313 | +162,313 | 0.00 | 0.16 | +0.16 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 150,000 | 150,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| Creative Planning | 0 | 149,856 | +149,856 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 146,100 | +146,100 | 0.00 | 0.00 | 0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 125,000 | +125,000 | 0.00 | 0.32 | +0.32 | buy |
| HRT FINANCIAL LP | 0 | 122,939 | +122,939 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 110,294 | +110,294 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 103,005 | +103,005 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 110,084 | 101,816 | -8,268 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 94,888 | 97,518 | +2,630 | 0.00 | 0.00 | -0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 92,653 | +92,653 | 0.00 | 0.02 | +0.02 | buy |
| PURA VIDA INVESTMENTS, LLC | 89,940 | 89,940 | 0 | 16.58 | 9.07 | -7.51 | hold |
| Trexquant Investment LP | 0 | 82,705 | +82,705 | 0.00 | 0.02 | +0.02 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 31,657 | 78,163 | +46,506 | 0.03 | 0.10 | +0.07 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 59,552 | 75,330 | +15,778 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 75,000 | 75,000 | 0 | 0.13 | 0.13 | +0.00 | hold |
| Engineers Gate Manager LP | 22,028 | 71,403 | +49,375 | 0.01 | 0.02 | +0.02 | buy |
| Gotham Asset Management, LLC | 33,203 | 67,186 | +33,983 | 0.00 | 0.01 | +0.00 | buy |
| Quantinno Capital Management LP | 72,223 | 64,922 | -7,301 | 0.01 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 0 | 64,397 | +64,397 | 0.00 | 0.00 | +0.00 | buy |
| HAMILTON LANE ADVISORS LLC | 0 | 58,725 | +58,725 | 0.00 | 0.87 | +0.87 | buy |
| Nikko Asset Management Americas, Inc. | 47,371 | 54,719 | +7,348 | 0.01 | 0.02 | +0.00 | buy |
| BARCLAYS PLC | 3,177 | 54,117 | +50,940 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 50,888 | +50,888 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 24,869 | 50,403 | +25,534 | 0.00 | 0.00 | +0.00 | buy |
| ELEMENT CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.70 | +0.70 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 45,976 | +45,976 | 0.00 | 0.10 | +0.10 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 42,483 | +42,483 | 0.00 | 0.09 | +0.09 | buy |
| Maven Securities LTD | 0 | 40,000 | +40,000 | 0.00 | 0.14 | +0.14 | buy |
| NORTHERN TRUST CORP | 45,595 | 36,948 | -8,647 | 0.00 | 0.00 | -0.00 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 35,050 | +35,050 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 175,544 | 33,505 | -142,039 | 0.00 | 0.00 | -0.00 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 31,029 | +31,029 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 48,445 | 30,725 | -17,720 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 30,157 | +30,157 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 26,670 | +26,670 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 26,343 | +26,343 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 15,991 | 25,711 | +9,720 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 25,290 | 25,290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PEAK6 LLC | 0 | 24,800 | +24,800 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 24,451 | +24,451 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 8,600 | 23,600 | +15,000 | 0.78 | 1.59 | +0.81 | buy |
| RHUMBLINE ADVISERS | 21,497 | 23,381 | +1,884 | 0.00 | 0.00 | -0.00 | buy |
| WPWealth LLP | 23,036 | 23,025 | -11 | 0.11 | 0.10 | -0.02 | sell |
| Nuveen, LLC | 22,413 | 22,413 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PDT Partners, LLC | 0 | 22,016 | +22,016 | 0.00 | 0.04 | +0.04 | buy |
| OAK RIDGE INVESTMENTS LLC | 0 | 21,820 | +21,820 | 0.00 | 0.04 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 1,201,985 | 20,387 | -1,181,598 | 0.01 | 0.00 | -0.01 | sell |