| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 9,633,435 | 14,217,768 | +4,584,333 | 0.02 | 0.02 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 3,113,956 | +3,113,956 | 0.00 | 0.06 | +0.06 | buy |
| PointState Capital LP | 3,883,721 | 6,718,707 | +2,834,986 | 2.11 | 3.10 | +0.99 | buy |
| UBS Group AG | 235,873 | 2,183,980 | +1,948,107 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 647,081 | 2,371,236 | +1,724,155 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 6,917 | 1,660,280 | +1,653,363 | 0.00 | 0.08 | +0.08 | buy |
| Point72 Asset Management, L.P. | 246,624 | 1,864,860 | +1,618,236 | 0.02 | 0.08 | +0.06 | buy |
| JPMORGAN CHASE & CO | 858,105 | 2,445,281 | +1,587,176 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 8,025,759 | 9,205,959 | +1,180,200 | 0.15 | 0.16 | +0.01 | buy |
| Champlain Investment Partners, LLC | 0 | 939,365 | +939,365 | 0.00 | 0.26 | +0.26 | buy |
| MARSHALL WACE, LLP | 82,975 | 1,002,734 | +919,759 | 0.00 | 0.03 | +0.02 | buy |
| FIL Ltd | 225,920 | 1,122,775 | +896,855 | 0.01 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 429,478 | 1,122,748 | +693,270 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,200 | 685,826 | +684,626 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 222,336 | 773,852 | +551,516 | 0.01 | 0.02 | +0.01 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 0 | 543,185 | +543,185 | 0.00 | 0.33 | +0.33 | buy |
| BRAIDWELL LP | 7,316,142 | 7,816,142 | +500,000 | 6.57 | 6.74 | +0.18 | buy |
| SEVEN GRAND MANAGERS, LLC | 100,000 | 495,095 | +395,095 | 0.25 | 1.02 | +0.77 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,116,191 | 1,470,295 | +354,104 | 0.01 | 0.01 | +0.00 | buy |
| Meridiem Capital Partners LP | 0 | 278,063 | +278,063 | 0.00 | 0.47 | +0.47 | buy |
| MORGAN STANLEY | 1,534,423 | 1,794,991 | +260,568 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 247,407 | +247,407 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 803,802 | 1,033,115 | +229,313 | 0.00 | 0.00 | -0.00 | buy |
| Longaeva Partners L.P. | 1,285,968 | 1,509,745 | +223,777 | 8.27 | 4.84 | -3.43 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 6,210 | 218,305 | +212,095 | 0.00 | 0.06 | +0.06 | buy |
| WORLDQUANT MILLENNIUM ADVISORS LLC | 10,092 | 188,861 | +178,769 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 32,752 | 206,993 | +174,241 | 0.00 | 0.01 | +0.01 | buy |
| ARK Investment Management LLC | 245,350 | 408,725 | +163,375 | 0.04 | 0.07 | +0.03 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 0 | 162,313 | +162,313 | 0.00 | 0.16 | +0.16 | buy |
| JANE STREET GROUP, LLC | 14,595 | 170,997 | +156,402 | 0.00 | 0.01 | +0.00 | buy |
| Creative Planning | 0 | 149,856 | +149,856 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 0 | 146,100 | +146,100 | 0.00 | 0.00 | 0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 1,322,752 | 1,464,558 | +141,806 | 0.03 | 0.03 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 0 | 125,000 | +125,000 | 0.00 | 0.32 | +0.32 | buy |
| HRT FINANCIAL LP | 0 | 122,939 | +122,939 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 110,294 | +110,294 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 155,340 | 260,645 | +105,305 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 225,100 | 329,900 | +104,800 | 0.01 | 0.01 | +0.00 | buy |
| Jump Financial, LLC | 0 | 103,005 | +103,005 | 0.00 | 0.03 | +0.03 | buy |
| TD Waterhouse Canada Inc. | 0 | 92,653 | +92,653 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 0 | 82,705 | +82,705 | 0.00 | 0.02 | +0.02 | buy |
| ORBIMED ADVISORS LLC | 3,034,858 | 3,116,011 | +81,153 | 2.20 | 1.72 | -0.48 | buy |
| GOLDMAN SACHS GROUP INC | 282,209 | 350,142 | +67,933 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 171,127 | 237,897 | +66,770 | 0.01 | 0.01 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 64,397 | +64,397 | 0.00 | 0.00 | +0.00 | buy |
| HAMILTON LANE ADVISORS LLC | 0 | 58,725 | +58,725 | 0.00 | 0.87 | +0.87 | buy |
| FRANKLIN RESOURCES INC | 216,964 | 268,615 | +51,651 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 3,177 | 54,117 | +50,940 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 50,888 | +50,888 | 0.00 | 0.06 | +0.06 | buy |
| ELEMENT CAPITAL MANAGEMENT LLC | 0 | 50,000 | +50,000 | 0.00 | 0.70 | +0.70 | buy |
| Engineers Gate Manager LP | 22,028 | 71,403 | +49,375 | 0.01 | 0.02 | +0.02 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 31,657 | 78,163 | +46,506 | 0.03 | 0.10 | +0.07 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 45,976 | +45,976 | 0.00 | 0.10 | +0.10 | buy |
| MANGROVE PARTNERS IM, LLC | 0 | 42,483 | +42,483 | 0.00 | 0.09 | +0.09 | buy |
| Maven Securities LTD | 0 | 40,000 | +40,000 | 0.00 | 0.14 | +0.14 | buy |
| PERCEPTIVE ADVISORS LLC | 1,098,163 | 1,136,206 | +38,043 | 0.96 | 0.56 | -0.40 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 35,050 | +35,050 | 0.00 | 0.00 | +0.00 | buy |
| Clearbridge Investments, LLC | 1,381,230 | 1,416,207 | +34,977 | 0.03 | 0.03 | -0.00 | buy |
| Gotham Asset Management, LLC | 33,203 | 67,186 | +33,983 | 0.00 | 0.01 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 31,029 | +31,029 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 30,157 | +30,157 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 0 | 26,670 | +26,670 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 26,343 | +26,343 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 24,869 | 50,403 | +25,534 | 0.00 | 0.00 | +0.00 | buy |
| PEAK6 LLC | 0 | 24,800 | +24,800 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 0 | 24,451 | +24,451 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 22,016 | +22,016 | 0.00 | 0.04 | +0.04 | buy |
| OAK RIDGE INVESTMENTS LLC | 0 | 21,820 | +21,820 | 0.00 | 0.04 | +0.04 | buy |
| Diversified Trust Co | 0 | 20,000 | +20,000 | 0.00 | 0.01 | +0.01 | buy |
| Magnetar Financial LLC | 0 | 17,493 | +17,493 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 16,490 | +16,490 | 0.00 | 0.01 | +0.01 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 59,552 | 75,330 | +15,778 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 15,235 | +15,235 | 0.00 | 0.04 | +0.04 | buy |
| Sandia Investment Management LP | 8,600 | 23,600 | +15,000 | 0.78 | 1.59 | +0.81 | buy |
| Mirae Asset Global Investments Co., Ltd. | 0 | 13,711 | +13,711 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 13,263 | +13,263 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 13,251 | +13,251 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 12,900 | +12,900 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 0 | 12,462 | +12,462 | 0.00 | 0.00 | +0.00 | buy |
| Temasek Holdings (Private) Ltd | 0 | 12,235 | +12,235 | 0.00 | 0.00 | +0.00 | buy |
| Michael & Susan Dell Foundation | 0 | 12,235 | +12,235 | 0.00 | 0.01 | +0.01 | buy |
| AXQ CAPITAL, LP | 0 | 12,212 | +12,212 | 0.00 | 0.07 | +0.07 | buy |
| Clal Insurance Enterprises Holdings Ltd | 0 | 11,930 | +11,930 | 0.00 | 0.00 | +0.00 | buy |
| Northwest & Ethical Investments L.P. | 0 | 10,600 | +10,600 | 0.00 | 0.01 | +0.01 | buy |
| Knollwood Investment Advisory, LLC | 0 | 10,445 | +10,445 | 0.00 | 0.03 | +0.03 | buy |
| Brevan Howard Capital Management LP | 0 | 9,767 | +9,767 | 0.00 | 0.01 | +0.01 | buy |
| LPL Financial LLC | 15,991 | 25,711 | +9,720 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 9,601 | +9,601 | 0.00 | 0.00 | +0.00 | buy |
| Summit Trail Advisors, LLC | 0 | 9,292 | +9,292 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 8,995 | +8,995 | 0.00 | 0.00 | +0.00 | buy |
| COURIER CAPITAL LLC | 0 | 8,550 | +8,550 | 0.00 | 0.01 | +0.01 | buy |
| OCCUDO QUANTITATIVE STRATEGIES LP | 0 | 8,355 | +8,355 | 0.00 | 0.02 | +0.02 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 7,925 | +7,925 | 0.00 | 0.00 | +0.00 | buy |
| Nikko Asset Management Americas, Inc. | 47,371 | 54,719 | +7,348 | 0.01 | 0.02 | +0.00 | buy |
| IQ EQ FUND MANAGEMENT (IRELAND) Ltd | 8,326 | 15,546 | +7,220 | 0.02 | 0.03 | +0.01 | buy |
| GF FUND MANAGEMENT CO. LTD. | 0 | 5,543 | +5,543 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 4,291 | 9,244 | +4,953 | 0.00 | 0.00 | +0.00 | buy |
| ADAMS STREET PARTNERS LLC | 0 | 4,894 | +4,894 | 0.00 | 0.05 | +0.05 | buy |
| EDMOND DE ROTHSCHILD HOLDING S.A. | 7,500 | 12,265 | +4,765 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 4,622 | +4,622 | 0.00 | 0.00 | +0.00 | buy |