| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Sanofi | 0 | 2,783,096 | +2,783,096 | 0.00 | 8.69 | +8.69 | buy |
| Cormorant Asset Management, LP | 0 | 2,465,348 | +2,465,348 | 0.00 | 1.30 | +1.30 | buy |
| TCG Crossover Management, LLC | 0 | 2,053,233 | +2,053,233 | 0.00 | 0.62 | +0.62 | buy |
| FEDERATED HERMES, INC. | 0 | 1,618,000 | +1,618,000 | 0.00 | 0.03 | +0.03 | buy |
| Casdin Capital, LLC | 0 | 1,550,000 | +1,550,000 | 0.00 | 1.23 | +1.23 | buy |
| FMR LLC | 0 | 1,458,677 | +1,458,677 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 0 | 1,200,000 | +1,200,000 | 0.00 | 0.80 | +0.80 | buy |
| Aberdeen Group plc | 0 | 707,656 | +707,656 | 0.00 | 0.01 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 600,000 | +600,000 | 0.00 | 0.12 | +0.12 | buy |
| Samsara BioCapital, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.61 | +0.61 | buy |
| Siren, L.L.C. | 0 | 411,250 | +411,250 | 0.00 | 0.12 | +0.12 | buy |
| LMR Partners LLP | 0 | 300,000 | +300,000 | 0.00 | 0.03 | +0.03 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 200,000 | +200,000 | 0.00 | 0.14 | +0.14 | buy |
| Redmile Group, LLC | 0 | 156,250 | +156,250 | 0.00 | 0.11 | +0.11 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 95,233 | +95,233 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 75,000 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| PFIZER INC | 0 | 75,000 | +75,000 | 0.00 | 0.34 | +0.34 | buy |
| Laurion Capital Management LP | 0 | 50,000 | +50,000 | 0.00 | 0.05 | +0.05 | buy |
| Bellevue Group AG | 0 | 50,000 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 43,500 | +43,500 | 0.00 | 0.40 | +0.40 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 35,739 | +35,739 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 35,000 | +35,000 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 35,000 | +35,000 | 0.00 | 0.02 | +0.02 | buy |
| HRT FINANCIAL LP | 0 | 23,726 | +23,726 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 15,326 | +15,326 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 14,241 | +14,241 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |