| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 156,250 | 2,733,926 | +2,577,676 | 0.11 | 2.38 | +2.27 | buy |
| Nantahala Capital Management, LLC | 1,200,000 | 1,568,188 | +368,188 | 0.80 | 1.23 | +0.43 | buy |
| ORBIMED ADVISORS LLC | 0 | 192,740 | +192,740 | 0.00 | 0.05 | +0.05 | buy |
| Aberdeen Group plc | 707,656 | 846,695 | +139,039 | 0.01 | 0.02 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 49,984 | +49,984 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 20,461 | +20,461 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 10,271 | +10,271 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 9,496 | +9,496 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 14,241 | 18,072 | +3,831 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 1,344 | +1,344 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 754 | +754 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 698 | +698 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1,618,000 | 1,618,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Sanofi | 2,783,096 | 2,783,096 | 0 | 8.69 | 6.76 | -1.93 | hold |
| PERCEPTIVE ADVISORS LLC | 600,000 | 600,000 | 0 | 0.12 | 0.12 | -0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 43,500 | 43,500 | 0 | 0.40 | 0.39 | -0.00 | hold |
| Casdin Capital, LLC | 1,550,000 | 1,550,000 | 0 | 1.23 | 1.01 | -0.22 | hold |
| Cormorant Asset Management, LP | 2,465,348 | 2,465,348 | 0 | 1.30 | 1.64 | +0.34 | hold |
| Samsara BioCapital, LLC | 600,000 | 600,000 | 0 | 0.61 | 0.64 | +0.03 | hold |
| TCG Crossover Management, LLC | 2,053,233 | 2,053,233 | 0 | 0.62 | 0.64 | +0.02 | hold |
| SBI Securities Co., Ltd. | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Burkehill Global Management, LP | 35,000 | 35,000 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Siren, L.L.C. | 411,250 | 411,250 | 0 | 0.12 | 0.11 | -0.01 | hold |
| FMR LLC | 1,458,677 | 1,458,677 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PFIZER INC | 75,000 | 75,000 | 0 | 0.34 | 0.61 | +0.27 | hold |
| Bellevue Group AG | 50,000 | 49,248 | -752 | 0.01 | 0.01 | +0.00 | sell |
| HRT FINANCIAL LP | 23,726 | 17,075 | -6,651 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 15,326 | 0 | -15,326 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 35,000 | 0 | -35,000 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 35,739 | 0 | -35,739 | 0.00 | 0.00 | -0.00 | sell |
| Laurion Capital Management LP | 50,000 | 0 | -50,000 | 0.05 | 0.00 | -0.05 | sell |
| Alyeska Investment Group, L.P. | 75,000 | 0 | -75,000 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 95,233 | 0 | -95,233 | 0.00 | 0.00 | -0.00 | sell |
| SEVEN GRAND MANAGERS, LLC | 200,000 | 47,600 | -152,400 | 0.14 | 0.02 | -0.12 | sell |
| LMR Partners LLP | 300,000 | 0 | -300,000 | 0.03 | 0.00 | -0.03 | sell |