| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Altshuler Shaham Ltd | 0 | 3,235,293 | +3,235,293 | 0.00 | 0.09 | +0.09 | buy |
| Deep Track Capital, LP | 1,000,000 | 2,299,567 | +1,299,567 | 0.62 | 0.46 | -0.16 | buy |
| Parkman Healthcare Partners LLC | 0 | 233,563 | +233,563 | 0.00 | 0.17 | +0.17 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 177,984 | +177,984 | 0.00 | 0.01 | +0.01 | buy |
| Velan Capital Investment Management LP | 0 | 107,000 | +107,000 | 0.00 | 0.67 | +0.67 | buy |
| FMR LLC | 7,176,187 | 7,255,859 | +79,672 | 0.01 | 0.00 | -0.00 | buy |
| BlackRock, Inc. | 1,117,800 | 1,185,768 | +67,968 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 61,796 | +61,796 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 247,187 | 295,587 | +48,400 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 363,269 | 410,677 | +47,408 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 526,511 | 557,063 | +30,552 | 0.06 | 0.02 | -0.04 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 21,789 | +21,789 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 18,822 | +18,822 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 15,285 | +15,285 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 15,225 | +15,225 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 15,000 | +15,000 | 0.00 | 0.02 | +0.02 | buy |
| MARSHALL WACE, LLP | 290,734 | 304,963 | +14,229 | 0.01 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 12,731 | +12,731 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,700 | +4,700 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 3,350 | +3,350 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 1,596 | +1,596 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 615 | +615 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 593 | +593 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,828 | 10,296 | +468 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 14,851 | 15,192 | +341 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,047 | 9,250 | +203 | 0.00 | 0.00 | -0.00 | buy |
| Allworth Financial LP | 0 | 185 | +185 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 136 | +136 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 135 | +135 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 90 | +90 | 0.00 | 0.00 | +0.00 | buy |
| Physician Wealth Advisors, Inc. | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 5,693,589 | 5,693,589 | 0 | 1.94 | 0.84 | -1.11 | hold |
| Ameritas Investment Partners, Inc. | 1,822 | 1,822 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,290 | 1,290 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 12 | 12 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GREAT POINT PARTNERS LLC | 300,000 | 300,000 | 0 | 2.32 | 1.00 | -1.33 | hold |
| Alyeska Investment Group, L.P. | 85,000 | 85,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 11,034 | 11,034 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 60,000 | 60,000 | 0 | 0.04 | 0.02 | -0.02 | hold |
| VR Adviser, LLC | 2,295,319 | 2,295,319 | 0 | 2.59 | 1.20 | -1.39 | hold |
| Omega Fund Management, LLC | 2,036,293 | 2,036,293 | 0 | 21.71 | 7.35 | -14.36 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,295,322 | 2,295,322 | 0 | 4.44 | 2.08 | -2.36 | hold |
| Walleye Capital LLC | 10,000 | 10,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TCG Crossover Management, LLC | 2,801,763 | 2,801,763 | 0 | 4.38 | 2.34 | -2.04 | hold |
| Enavate Sciences GP, LLC | 2,459,703 | 2,459,703 | 0 | 29.04 | 11.34 | -17.70 | hold |
| Decheng Capital LLC | 3,285,293 | 3,285,293 | 0 | 11.58 | 5.64 | -5.94 | hold |
| Legal & General Group Plc | 1,734 | 1,734 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STRS OHIO | 3,200 | 3,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMALGAMATED BANK | 594 | 594 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Bank of New York Mellon Corp | 36,913 | 36,912 | -1 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 7 | 0 | -7 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 44 | 0 | -44 | 0.00 | 0.00 | -0.00 | sell |
| Sterling Capital Management LLC | 249 | 137 | -112 | 0.00 | 0.00 | -0.00 | sell |
| Corebridge Financial, Inc. | 8,660 | 8,533 | -127 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 134 | 0 | -134 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 160 | 0 | -160 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 15,602 | 15,315 | -287 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,511 | 939 | -572 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 1,660 | 562 | -1,098 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 2,846 | 1,582 | -1,264 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 27,017 | 24,993 | -2,024 | 0.00 | 0.00 | -0.00 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 135,323 | 132,173 | -3,150 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 16,721 | 13,327 | -3,394 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 43,340 | 39,079 | -4,261 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 600,000 | 594,971 | -5,029 | 0.69 | 0.30 | -0.39 | sell |
| NORTHERN TRUST CORP | 143,721 | 137,771 | -5,950 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 7,590 | 0 | -7,590 | 0.00 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 915,021 | 907,026 | -7,995 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 26,504 | 18,178 | -8,326 | 0.00 | 0.00 | -0.00 | sell |
| Sandia Investment Management LP | 10,000 | 0 | -10,000 | 0.31 | 0.00 | -0.31 | sell |
| GOLDMAN SACHS GROUP INC | 44,490 | 32,955 | -11,535 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 800,000 | 788,450 | -11,550 | 0.58 | 0.27 | -0.31 | sell |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 12,500 | 0 | -12,500 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,111,337 | 1,091,186 | -20,151 | 0.01 | 0.00 | -0.00 | sell |
| Lynx1 Capital Management LP | 240,042 | 219,247 | -20,795 | 1.48 | 0.48 | -1.00 | sell |
| UBS Group AG | 161,512 | 131,551 | -29,961 | 0.00 | 0.00 | -0.00 | sell |
| NORGES BANK | 1,000,000 | 969,916 | -30,084 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 47,792 | 15,194 | -32,598 | 0.00 | 0.00 | -0.00 | sell |
| Verition Fund Management LLC | 37,379 | 0 | -37,379 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 45,549 | 0 | -45,549 | 0.00 | 0.00 | -0.00 | sell |
| SOROS FUND MANAGEMENT LLC | 46,350 | 0 | -46,350 | 0.01 | 0.00 | -0.01 | sell |
| MOODY ALDRICH PARTNERS LLC | 74,773 | 0 | -74,773 | 0.23 | 0.00 | -0.23 | sell |
| Samsara BioCapital, LLC | 2,217,146 | 2,067,146 | -150,000 | 5.00 | 2.26 | -2.75 | sell |
| CITADEL ADVISORS LLC | 180,000 | 0 | -180,000 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,583,154 | 1,313,457 | -269,697 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 301,152 | 0 | -301,152 | 0.01 | 0.00 | -0.01 | sell |