| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 7,518,202 | 8,101,563 | +583,361 | 0.01 | 0.00 | -0.01 | buy |
| ORBIMED ADVISORS LLC | 5,693,589 | 5,693,589 | 0 | 3.16 | 1.12 | -2.05 | hold |
| BlackRock, Inc. | 3,344,504 | 3,370,689 | +26,185 | 0.00 | 0.00 | -0.00 | buy |
| Decheng Capital LLC | 3,143,078 | 2,724,868 | -418,210 | 11.48 | 3.71 | -7.77 | sell |
| Enavate Sciences GP, LLC | 2,459,703 | 2,459,703 | 0 | 13.18 | 6.30 | -6.88 | hold |
| Y-Intercept (Hong Kong) Ltd | 46,559 | 1,000,631 | +954,072 | 0.03 | 0.17 | +0.14 | buy |
| FEDERATED HERMES, INC. | 482 | 979,758 | +979,276 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 851,908 | 950,617 | +98,709 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 517,264 | 937,323 | +420,059 | 0.01 | 0.01 | -0.00 | buy |
| Bain Capital Life Sciences Investors, LLC | 1,329,544 | 867,211 | -462,333 | 2.76 | 0.70 | -2.06 | sell |
| Woodline Partners LP | 760,252 | 831,481 | +71,229 | 0.08 | 0.03 | -0.05 | buy |
| D. E. Shaw & Co., Inc. | 27,091 | 820,480 | +793,389 | 0.00 | 0.01 | +0.01 | buy |
| Parkman Healthcare Partners LLC | 834,559 | 786,783 | -47,776 | 2.16 | 0.73 | -1.42 | sell |
| Samsara BioCapital, LLC | 736,047 | 736,047 | 0 | 2.06 | 0.64 | -1.42 | hold |
| Pictet Asset Management Holding SA | 773,148 | 733,431 | -39,717 | 0.02 | 0.01 | -0.01 | sell |
| STATE STREET CORP | 1,319,226 | 705,350 | -613,876 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 0 | 640,326 | +640,326 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 619,321 | +619,321 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 122,068 | 552,609 | +430,541 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 110,280 | 463,001 | +352,721 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 494,971 | 400,000 | -94,971 | 0.80 | 0.22 | -0.58 | sell |
| Altshuler Shaham Ltd | 1,341,540 | 380,061 | -961,479 | 0.56 | 0.06 | -0.49 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 358,000 | +358,000 | 0.00 | 0.55 | +0.55 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 894,733 | 342,353 | -552,380 | 0.00 | 0.00 | -0.00 | sell |
| Propel Bio Management, LLC | 0 | 341,779 | +341,779 | 0.00 | 1.95 | +1.95 | buy |
| Jump Financial, LLC | 0 | 319,400 | +319,400 | 0.00 | 0.04 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 333,481 | 316,587 | -16,894 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 298,329 | 298,329 | 0 | 0.02 | 0.01 | -0.02 | hold |
| NORTHERN TRUST CORP | 236,799 | 260,992 | +24,193 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 284,931 | 257,729 | -27,202 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 0 | 241,123 | +241,123 | 0.00 | 0.36 | +0.36 | buy |
| UBS Group AG | 1,806,243 | 231,254 | -1,574,989 | 0.01 | 0.00 | -0.01 | sell |
| XTX Topco Ltd | 15,091 | 209,277 | +194,186 | 0.01 | 0.03 | +0.02 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 185,087 | +185,087 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 743,886 | 181,063 | -562,823 | 0.67 | 0.05 | -0.62 | sell |
| DEUTSCHE BANK AG\ | 127,815 | 180,889 | +53,074 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 178,168 | +178,168 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 31,049 | 176,657 | +145,608 | 0.01 | 0.01 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 115,807 | 161,349 | +45,542 | 0.02 | 0.01 | -0.00 | buy |
| Boxer Capital Management, LLC | 150,000 | 150,000 | 0 | 0.89 | 0.18 | -0.71 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 4,976 | 126,000 | +121,024 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 75,402 | 91,431 | +16,029 | 0.02 | 0.01 | -0.01 | buy |
| AMERICAN CENTURY COMPANIES INC | 87,756 | 87,624 | -132 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 84,853 | 81,383 | -3,470 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 0 | 80,002 | +80,002 | 0.00 | 0.00 | +0.00 | buy |
| Simplify Asset Management Inc. | 0 | 77,793 | +77,793 | 0.00 | 0.01 | +0.01 | buy |
| Nuveen, LLC | 78,568 | 75,536 | -3,032 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 0 | 73,568 | +73,568 | 0.00 | 0.19 | +0.19 | buy |
| AQR CAPITAL MANAGEMENT LLC | 30,503 | 72,171 | +41,668 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 343,791 | 66,770 | -277,021 | 0.01 | 0.00 | -0.01 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 16,400 | 62,100 | +45,700 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 15,415 | 49,389 | +33,974 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 86,384 | 48,460 | -37,924 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 26,600 | 48,100 | +21,500 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 0 | 44,626 | +44,626 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 44,376 | 43,992 | -384 | 0.01 | 0.00 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 41,671 | +41,671 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,523 | 41,203 | -320 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 163,186 | 40,510 | -122,676 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,652 | 39,661 | +25,009 | 0.00 | 0.00 | -0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 39,232 | +39,232 | 0.00 | 0.02 | +0.02 | buy |
| Stonepine Capital Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.28 | +0.28 | buy |
| ADAR1 Capital Management, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 0 | 31,484 | +31,484 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,010 | 31,010 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bleakley Financial Group, LLC | 0 | 28,864 | +28,864 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 27,503 | +27,503 | 0.00 | 0.03 | +0.03 | buy |
| Mariner, LLC | 11,830 | 27,314 | +15,484 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 19,636 | 26,434 | +6,798 | 0.00 | 0.00 | -0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 26,412 | +26,412 | 0.00 | 0.00 | +0.00 | buy |
| MARTINGALE ASSET MANAGEMENT L P | 0 | 26,223 | +26,223 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 25,866 | +25,866 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 524,499 | 24,720 | -499,779 | 0.01 | 0.00 | -0.01 | sell |
| DnB Asset Management AS | 12,793 | 23,515 | +10,722 | 0.00 | 0.00 | -0.00 | buy |
| Entropy Technologies, LP | 0 | 23,336 | +23,336 | 0.00 | 0.01 | +0.01 | buy |
| DIADEMA PARTNERS LP | 20,500 | 21,609 | +1,109 | 0.33 | 0.08 | -0.25 | buy |
| Man Group plc | 0 | 21,154 | +21,154 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 400 | 19,558 | +19,158 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,678 | 19,380 | -298 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 36,794 | 18,402 | -18,392 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 17,491 | 15,608 | -1,883 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,147 | 15,338 | +5,191 | 0.00 | 0.00 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 14,589 | +14,589 | 0.00 | 0.00 | +0.00 | buy |
| Corient Private Wealth LLC | 0 | 12,157 | +12,157 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,749 | 10,850 | -899 | 0.00 | 0.00 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 9,801 | 10,046 | +245 | 0.07 | 0.02 | -0.05 | buy |
| Shay Capital LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| STRS OHIO | 9,800 | 9,800 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 13,709 | 9,609 | -4,100 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 8,806 | 9,590 | +784 | 0.02 | 0.01 | -0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,456 | 9,456 | 0 | 0.00 | 0.00 | -0.00 | hold |
| KLP KAPITALFORVALTNING AS | 2,900 | 5,900 | +3,000 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 8,907 | 5,495 | -3,412 | 0.12 | 0.02 | -0.10 | sell |
| CITIGROUP INC | 6,949 | 5,055 | -1,894 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 3,360 | 3,883 | +523 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 2,823 | 3,647 | +824 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,626 | 2,819 | +193 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,741 | 2,741 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Tower Research Capital LLC (TRC) | 669 | 1,425 | +756 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,061 | 1,203 | +142 | 0.00 | 0.00 | -0.00 | buy |