| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 907,026 | 2,170,833 | +1,263,807 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,185,768 | 2,096,506 | +910,738 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 7,255,859 | 7,936,880 | +681,021 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 233,563 | 715,504 | +481,941 | 0.17 | 0.91 | +0.74 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 410,677 | 646,635 | +235,958 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 177,984 | 365,790 | +187,806 | 0.01 | 0.03 | +0.02 | buy |
| STATE STREET CORP | 295,587 | 481,375 | +185,788 | 0.00 | 0.00 | +0.00 | buy |
| Altshuler Shaham Ltd | 3,235,293 | 3,394,441 | +159,148 | 0.09 | 1.18 | +1.10 | buy |
| Bain Capital Life Sciences Investors, LLC | 2,295,322 | 2,439,538 | +144,216 | 2.08 | 3.35 | +1.27 | buy |
| UBS Group AG | 131,551 | 232,887 | +101,336 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 137,771 | 229,303 | +91,532 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 24,993 | 96,990 | +71,997 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 22,586 | 73,936 | +51,350 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,173 | 178,253 | +46,080 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 36,912 | 79,766 | +42,854 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 42,263 | +42,263 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 13,327 | 48,066 | +34,739 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 33,505 | +33,505 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 22,362 | +22,362 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 17,448 | +17,448 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 15,526 | +15,526 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 0 | 14,030 | +14,030 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 13,190 | +13,190 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,250 | 22,364 | +13,114 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 18,822 | 29,752 | +10,930 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 11,034 | 21,691 | +10,657 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 10,296 | 19,084 | +8,788 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 15,192 | 23,403 | +8,211 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 8,134 | +8,134 | 0.00 | 0.03 | +0.03 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 15,285 | 21,290 | +6,005 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 3,350 | 7,833 | +4,483 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 939 | 3,097 | +2,158 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,822 | 3,558 | +1,736 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 1,596 | 3,312 | +1,716 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,582 | 3,051 | +1,469 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,734 | 3,174 | +1,440 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 15,194 | 16,469 | +1,275 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 557,063 | 558,252 | +1,189 | 0.02 | 0.03 | +0.01 | buy |
| Invesco Ltd. | 15,315 | 16,300 | +985 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,290 | 2,174 | +884 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 137 | 941 | +804 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 224 | +224 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 135 | 309 | +174 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 163 | +163 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 147 | +147 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 593 | 693 | +100 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 562 | 659 | +97 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 16 | 31 | +15 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 5,693,589 | 5,693,589 | 0 | 0.84 | 1.57 | +0.74 | hold |
| GREAT POINT PARTNERS LLC | 300,000 | 300,000 | 0 | 1.00 | 2.14 | +1.14 | hold |
| NORGES BANK | 969,916 | 969,916 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Alyeska Investment Group, L.P. | 85,000 | 85,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 594,971 | 594,971 | 0 | 0.30 | 0.46 | +0.16 | hold |
| VR Adviser, LLC | 2,295,319 | 2,295,319 | 0 | 1.20 | 1.89 | +0.69 | hold |
| Omega Fund Management, LLC | 2,036,293 | 2,036,293 | 0 | 7.35 | 14.48 | +7.12 | hold |
| TCG Crossover Management, LLC | 2,801,763 | 2,801,763 | 0 | 2.34 | 3.51 | +1.17 | hold |
| Velan Capital Investment Management LP | 107,000 | 107,000 | 0 | 0.67 | 1.18 | +0.50 | hold |
| Lynx1 Capital Management LP | 219,247 | 219,247 | 0 | 0.48 | 0.70 | +0.21 | hold |
| Enavate Sciences GP, LLC | 2,459,703 | 2,459,703 | 0 | 11.34 | 15.30 | +3.96 | hold |
| Siren, L.L.C. | 788,450 | 788,450 | 0 | 0.27 | 0.45 | +0.18 | hold |
| Decheng Capital LLC | 3,285,293 | 3,285,293 | 0 | 5.64 | 9.11 | +3.47 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,700 | 4,700 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 594 | 594 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 12 | 0 | -12 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 136 | 96 | -40 | 0.00 | 0.00 | +0.00 | sell |
| SIGNATUREFD, LLC | 90 | 49 | -41 | 0.00 | 0.00 | -0.00 | sell |
| Versant Capital Management, Inc | 615 | 558 | -57 | 0.00 | 0.00 | +0.00 | sell |
| Physician Wealth Advisors, Inc. | 69 | 0 | -69 | 0.00 | 0.00 | -0.00 | sell |
| Allworth Financial LP | 185 | 66 | -119 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 3,200 | 1,800 | -1,400 | 0.00 | 0.00 | -0.00 | sell |
| Quantinno Capital Management LP | 15,225 | 10,614 | -4,611 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 18,178 | 11,695 | -6,483 | 0.00 | 0.00 | +0.00 | sell |
| Corebridge Financial, Inc. | 8,533 | 0 | -8,533 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 10,000 | 0 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 39,079 | 28,976 | -10,103 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 12,731 | 0 | -12,731 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 304,963 | 290,526 | -14,437 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 15,000 | 0 | -15,000 | 0.02 | 0.00 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 21,789 | 0 | -21,789 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 32,955 | 0 | -32,955 | 0.00 | 0.00 | -0.00 | sell |
| EcoR1 Capital, LLC | 60,000 | 0 | -60,000 | 0.02 | 0.00 | -0.02 | sell |
| MILLENNIUM MANAGEMENT LLC | 61,796 | 0 | -61,796 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,313,457 | 1,225,295 | -88,162 | 0.00 | 0.00 | +0.00 | sell |
| Samsara BioCapital, LLC | 2,067,146 | 1,443,231 | -623,915 | 2.26 | 3.24 | +0.99 | sell |
| Deep Track Capital, LP | 2,299,567 | 1,442,767 | -856,800 | 0.46 | 0.51 | +0.05 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,091,186 | 24,560 | -1,066,626 | 0.00 | 0.00 | -0.00 | sell |