| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,101,563 | 8,162,897 | +61,334 | 0.00 | 0.00 | -0.00 | buy |
| ORBIMED ADVISORS LLC | 5,693,589 | 5,693,589 | 0 | 1.12 | 0.75 | -0.37 | hold |
| NORGES BANK | 0 | 3,768,619 | +3,768,619 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 3,370,689 | 3,753,358 | +382,669 | 0.00 | 0.00 | -0.00 | buy |
| Decheng Capital LLC | 2,724,868 | 2,724,868 | 0 | 3.71 | 2.58 | -1.13 | hold |
| Enavate Sciences GP, LLC | 2,459,703 | 2,459,703 | 0 | 6.30 | 4.93 | -1.37 | hold |
| MILLENNIUM MANAGEMENT LLC | 937,323 | 1,143,775 | +206,452 | 0.01 | 0.01 | -0.00 | buy |
| D. E. Shaw & Co., Inc. | 820,480 | 1,036,044 | +215,564 | 0.01 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 463,001 | 1,012,044 | +549,043 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 619,321 | 978,500 | +359,179 | 0.01 | 0.01 | -0.00 | buy |
| Parkman Healthcare Partners LLC | 786,783 | 935,247 | +148,464 | 0.73 | 0.66 | -0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 950,617 | 931,261 | -19,356 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 831,481 | 831,481 | 0 | 0.03 | 0.02 | -0.01 | hold |
| STATE STREET CORP | 705,350 | 766,323 | +60,973 | 0.00 | 0.00 | -0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 1,000,631 | 693,555 | -307,076 | 0.17 | 0.09 | -0.08 | sell |
| Bain Capital Life Sciences Investors, LLC | 867,211 | 600,949 | -266,262 | 0.70 | 0.25 | -0.46 | sell |
| AQR CAPITAL MANAGEMENT LLC | 72,171 | 544,869 | +472,698 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 552,609 | 524,632 | -27,977 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 126,000 | 511,546 | +385,546 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 498,490 | +498,490 | 0.00 | 0.02 | +0.02 | buy |
| Trexquant Investment LP | 176,657 | 466,430 | +289,773 | 0.01 | 0.02 | +0.01 | buy |
| Point72 Asset Management, L.P. | 178,168 | 453,011 | +274,843 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 48,460 | 391,762 | +343,302 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 80,002 | 381,613 | +301,611 | 0.00 | 0.00 | +0.00 | buy |
| Altshuler Shaham Ltd | 380,061 | 380,061 | 0 | 0.06 | 0.03 | -0.03 | hold |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 185,087 | 357,756 | +172,669 | 0.00 | 0.00 | +0.00 | buy |
| Samsara BioCapital, LLC | 736,047 | 353,717 | -382,330 | 0.64 | 0.20 | -0.44 | sell |
| Propel Bio Management, LLC | 341,779 | 350,389 | +8,610 | 1.95 | 1.27 | -0.69 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 342,353 | 342,353 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 260,992 | 297,346 | +36,354 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 44,626 | 290,904 | +246,278 | 0.00 | 0.00 | +0.00 | buy |
| Voleon Capital Management LP | 0 | 285,234 | +285,234 | 0.00 | 0.04 | +0.04 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 262,456 | +262,456 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 257,729 | 262,456 | +4,727 | 0.00 | 0.00 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 253,092 | +253,092 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 316,587 | 246,917 | -69,670 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 209,277 | 242,346 | +33,069 | 0.03 | 0.02 | -0.01 | buy |
| DEUTSCHE BANK AG\ | 180,889 | 241,447 | +60,558 | 0.00 | 0.00 | -0.00 | buy |
| UBS Group AG | 231,254 | 234,714 | +3,460 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 161,349 | 225,760 | +64,411 | 0.01 | 0.01 | -0.00 | buy |
| Jump Financial, LLC | 319,400 | 223,223 | -96,177 | 0.04 | 0.01 | -0.03 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 358,000 | 219,700 | -138,300 | 0.55 | 0.22 | -0.34 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 175,110 | +175,110 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 170,590 | +170,590 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 150,000 | 150,000 | 0 | 0.18 | 0.08 | -0.10 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 62,100 | 131,300 | +69,200 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 73,568 | 129,446 | +55,878 | 0.19 | 0.22 | +0.02 | buy |
| ALGERT GLOBAL LLC | 0 | 118,630 | +118,630 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 81,383 | 85,747 | +4,364 | 0.00 | 0.00 | -0.00 | buy |
| Nuveen, LLC | 75,536 | 84,770 | +9,234 | 0.00 | 0.00 | -0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 87,624 | 78,194 | -9,430 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 21,154 | 73,823 | +52,669 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 39,232 | 69,348 | +30,116 | 0.02 | 0.03 | +0.01 | buy |
| Simplify Asset Management Inc. | 77,793 | 62,113 | -15,680 | 0.01 | 0.01 | -0.00 | sell |
| ALPS ADVISORS INC | 43,992 | 55,228 | +11,236 | 0.00 | 0.00 | -0.00 | buy |
| Quantinno Capital Management LP | 49,389 | 54,838 | +5,449 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 10,046 | 53,638 | +43,592 | 0.02 | 0.09 | +0.06 | buy |
| Invesco Ltd. | 40,510 | 53,397 | +12,887 | 0.00 | 0.00 | -0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 31,010 | 51,680 | +20,670 | 0.00 | 0.00 | -0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 50,369 | +50,369 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 48,100 | 48,100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Russell Investments Group, Ltd. | 3,647 | 47,458 | +43,811 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 43,182 | +43,182 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,203 | 42,384 | +1,181 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 42,325 | +42,325 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 91,431 | 41,045 | -50,386 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 5,055 | 40,339 | +35,284 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 39,661 | 38,634 | -1,027 | 0.00 | 0.00 | -0.00 | sell |
| Stonepine Capital Management, LLC | 35,000 | 33,432 | -1,568 | 0.28 | 0.18 | -0.10 | sell |
| Mariner, LLC | 27,314 | 33,141 | +5,827 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 18,402 | 29,497 | +11,095 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 24,720 | 29,208 | +4,488 | 0.00 | 0.00 | -0.00 | buy |
| Creative Planning | 10,850 | 28,483 | +17,633 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 663 | 28,178 | +27,515 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 26,434 | 28,058 | +1,624 | 0.00 | 0.00 | -0.00 | buy |
| AXQ CAPITAL, LP | 27,503 | 27,068 | -435 | 0.03 | 0.02 | -0.01 | sell |
| nVerses Capital, LLC | 0 | 24,029 | +24,029 | 0.00 | 0.26 | +0.26 | buy |
| DnB Asset Management AS | 23,515 | 23,600 | +85 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 22,508 | +22,508 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 22,385 | +22,385 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 19,380 | 20,852 | +1,472 | 0.00 | 0.00 | -0.00 | buy |
| SG Americas Securities, LLC | 0 | 20,338 | +20,338 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 20,026 | +20,026 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 19,800 | +19,800 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 19,535 | +19,535 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 21,609 | 19,093 | -2,516 | 0.08 | 0.05 | -0.03 | sell |
| Shay Capital LLC | 10,000 | 18,000 | +8,000 | 0.01 | 0.01 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 17,988 | +17,988 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 23,336 | 17,542 | -5,794 | 0.01 | 0.00 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 41,671 | 17,065 | -24,606 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 15,608 | 16,217 | +609 | 0.00 | 0.00 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,338 | 15,735 | +397 | 0.00 | 0.00 | -0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 13,352 | +13,352 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 9,609 | 12,561 | +2,952 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 12,491 | +12,491 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 9,800 | 12,000 | +2,200 | 0.00 | 0.00 | -0.00 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 11,500 | +11,500 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 640,326 | 10,793 | -629,533 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 10,550 | +10,550 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 10,487 | +10,487 | 0.00 | 0.00 | +0.00 | buy |