| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 481,375 | 1,114,581 | +633,206 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 290,526 | 867,999 | +577,473 | 0.00 | 0.02 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 575,000 | +575,000 | 0.00 | 0.79 | +0.79 | buy |
| BlackRock, Inc. | 2,096,506 | 2,603,706 | +507,200 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,170,833 | 2,442,551 | +271,718 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 223,214 | +223,214 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 646,635 | 817,109 | +170,474 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 161,113 | +161,113 | 0.00 | 0.61 | +0.61 | buy |
| FMR LLC | 7,936,880 | 8,086,413 | +149,533 | 0.00 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 715,504 | 843,502 | +127,998 | 0.91 | 1.74 | +0.83 | buy |
| SummitTX Capital, L.P. | 0 | 112,404 | +112,404 | 0.00 | 0.09 | +0.09 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 178,253 | 284,828 | +106,575 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 87,535 | +87,535 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 73,131 | +73,131 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 61,299 | +61,299 | 0.00 | 0.03 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 55,473 | +55,473 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 51,960 | +51,960 | 0.00 | 0.65 | +0.65 | buy |
| AMERICAN CENTURY COMPANIES INC | 22,362 | 71,540 | +49,178 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 558,252 | 602,252 | +44,000 | 0.03 | 0.05 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 40,113 | +40,113 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 232,887 | 272,271 | +39,384 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 34,521 | +34,521 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 11,695 | 42,037 | +30,342 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA HOLDINGS INC | 0 | 28,290 | +28,290 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 229,303 | 254,719 | +25,416 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 18,196 | +18,196 | 0.00 | 0.02 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 15,735 | +15,735 | 0.00 | 0.02 | +0.02 | buy |
| Verition Fund Management LLC | 33,505 | 47,001 | +13,496 | 0.00 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 16,469 | 29,947 | +13,478 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 79,766 | 91,521 | +11,755 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 10,933 | +10,933 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 10,500 | +10,500 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 10,614 | 14,889 | +4,275 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 3,097 | 6,527 | +3,430 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 23,403 | 26,737 | +3,334 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 147 | 3,034 | +2,887 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 22,364 | 25,160 | +2,796 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,134 | 9,843 | +1,709 | 0.03 | 0.05 | +0.02 | buy |
| Police & Firemen's Retirement System of New Jersey | 7,833 | 9,447 | +1,614 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,700 | 6,300 | +1,600 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 48,066 | 49,406 | +1,340 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 941 | 2,264 | +1,323 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 1,305 | +1,305 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 1,141 | +1,141 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 17,448 | 18,501 | +1,053 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 16,300 | 17,190 | +890 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 332 | +332 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 14,030 | 14,266 | +236 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 29,752 | 29,954 | +202 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 693 | 890 | +197 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 149 | +149 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 128 | +128 | 0.00 | 0.00 | +0.00 | buy |
| N.E.W. Advisory Services LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 3,312 | 3,341 | +29 | 0.00 | 0.00 | +0.00 | buy |
| Sunbelt Securities, Inc. | 0 | 19 | +19 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,174 | 2,176 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 49 | 51 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 66 | 67 | +1 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 1 | 2 | +1 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 309 | 310 | +1 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 5,693,589 | 5,693,589 | 0 | 1.57 | 2.57 | +1.00 | hold |
| GREAT POINT PARTNERS LLC | 300,000 | 300,000 | 0 | 2.14 | 2.36 | +0.21 | hold |
| Nantahala Capital Management, LLC | 594,971 | 594,971 | 0 | 0.46 | 0.69 | +0.23 | hold |
| MetLife Investment Management, LLC | 21,691 | 21,691 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Parallel Advisors, LLC | 2 | 2 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Bain Capital Life Sciences Investors, LLC | 2,439,538 | 2,439,538 | 0 | 3.35 | 3.05 | -0.31 | hold |
| Enavate Sciences GP, LLC | 2,459,703 | 2,459,703 | 0 | 15.30 | 14.13 | -1.17 | hold |
| Siren, L.L.C. | 788,450 | 788,450 | 0 | 0.45 | 0.58 | +0.13 | hold |
| Decheng Capital LLC | 3,285,293 | 3,285,293 | 0 | 9.11 | 10.78 | +1.67 | hold |
| Clearstead Advisors, LLC | 163 | 163 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 594 | 594 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NISA INVESTMENT ADVISORS, LLC | 96 | 96 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Versant Capital Management, Inc | 558 | 548 | -10 | 0.00 | 0.00 | +0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 15,526 | 15,503 | -23 | 0.00 | 0.00 | +0.00 | sell |
| True Wealth Design, LLC | 31 | 0 | -31 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 659 | 531 | -128 | 0.00 | 0.00 | +0.00 | sell |
| Caitong International Asset Management Co., Ltd | 224 | 0 | -224 | 0.00 | 0.00 | -0.00 | sell |
| Legal & General Group Plc | 3,174 | 2,924 | -250 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 3,558 | 2,741 | -817 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,190 | 12,092 | -1,098 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 3,051 | 1,868 | -1,183 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 1,800 | 0 | -1,800 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 19,084 | 16,863 | -2,221 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 28,976 | 25,962 | -3,014 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 73,936 | 69,882 | -4,054 | 0.00 | 0.00 | +0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 24,560 | 19,850 | -4,710 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 21,290 | 10,396 | -10,894 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 96,990 | 85,315 | -11,675 | 0.00 | 0.00 | +0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,263 | 0 | -42,263 | 0.00 | 0.00 | -0.00 | sell |
| Alyeska Investment Group, L.P. | 85,000 | 0 | -85,000 | 0.00 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,225,295 | 1,125,395 | -99,900 | 0.00 | 0.00 | +0.00 | sell |
| Velan Capital Investment Management LP | 107,000 | 0 | -107,000 | 1.18 | 0.00 | -1.18 | sell |
| Schonfeld Strategic Advisors LLC | 365,790 | 190,244 | -175,546 | 0.03 | 0.02 | -0.01 | sell |
| Lynx1 Capital Management LP | 219,247 | 0 | -219,247 | 0.70 | 0.00 | -0.70 | sell |
| Samsara BioCapital, LLC | 1,443,231 | 962,154 | -481,077 | 3.24 | 2.36 | -0.88 | sell |
| Omega Fund Management, LLC | 2,036,293 | 1,356,293 | -680,000 | 14.48 | 11.47 | -3.00 | sell |
| TCG Crossover Management, LLC | 2,801,763 | 2,117,103 | -684,660 | 3.51 | 1.96 | -1.55 | sell |
| NORGES BANK | 969,916 | 0 | -969,916 | 0.00 | 0.00 | -0.00 | sell |
| VR Adviser, LLC | 2,295,319 | 1,169,298 | -1,126,021 | 1.89 | 1.24 | -0.65 | sell |
| Deep Track Capital, LP | 1,442,767 | 0 | -1,442,767 | 0.51 | 0.00 | -0.51 | sell |