| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 0 | 7,176,187 | +7,176,187 | 0.00 | 0.01 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 0 | 5,693,589 | +5,693,589 | 0.00 | 1.94 | +1.94 | buy |
| Decheng Capital LLC | 0 | 3,285,293 | +3,285,293 | 0.00 | 11.58 | +11.58 | buy |
| TCG Crossover Management, LLC | 0 | 2,801,763 | +2,801,763 | 0.00 | 4.38 | +4.38 | buy |
| Bain Capital Life Sciences Investors, LLC | 0 | 2,295,322 | +2,295,322 | 0.00 | 4.44 | +4.44 | buy |
| VR Adviser, LLC | 0 | 2,295,319 | +2,295,319 | 0.00 | 2.59 | +2.59 | buy |
| Samsara BioCapital, LLC | 0 | 2,217,146 | +2,217,146 | 0.00 | 5.00 | +5.00 | buy |
| Omega Fund Management, LLC | 0 | 2,036,293 | +2,036,293 | 0.00 | 21.71 | +21.71 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 1,583,154 | +1,583,154 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 0 | 1,117,800 | +1,117,800 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 1,111,337 | +1,111,337 | 0.00 | 0.01 | +0.01 | buy |
| NORGES BANK | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.62 | +0.62 | buy |
| VANGUARD GROUP INC | 0 | 915,021 | +915,021 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 800,000 | +800,000 | 0.00 | 0.58 | +0.58 | buy |
| Nantahala Capital Management, LLC | 0 | 600,000 | +600,000 | 0.00 | 0.69 | +0.69 | buy |
| Woodline Partners LP | 0 | 526,511 | +526,511 | 0.00 | 0.06 | +0.06 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 363,269 | +363,269 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 301,152 | +301,152 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 0 | 300,000 | +300,000 | 0.00 | 2.32 | +2.32 | buy |
| MARSHALL WACE, LLP | 0 | 290,734 | +290,734 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 0 | 247,187 | +247,187 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 0 | 240,042 | +240,042 | 0.00 | 1.48 | +1.48 | buy |
| CITADEL ADVISORS LLC | 0 | 180,000 | +180,000 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 161,512 | +161,512 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 143,721 | +143,721 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 135,323 | +135,323 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 85,000 | +85,000 | 0.00 | 0.01 | +0.01 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 74,773 | +74,773 | 0.00 | 0.23 | +0.23 | buy |
| EcoR1 Capital, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.04 | +0.04 | buy |
| JPMORGAN CHASE & CO | 0 | 47,792 | +47,792 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 46,350 | +46,350 | 0.00 | 0.01 | +0.01 | buy |
| JANE STREET GROUP, LLC | 0 | 45,549 | +45,549 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 44,490 | +44,490 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 0 | 43,340 | +43,340 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 37,379 | +37,379 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 36,913 | +36,913 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 27,017 | +27,017 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 26,504 | +26,504 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 16,721 | +16,721 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 15,602 | +15,602 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 14,851 | +14,851 | 0.00 | 0.00 | +0.00 | buy |
| DAVIDSON KEMPNER CAPITAL MANAGEMENT LP | 0 | 12,500 | +12,500 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 11,034 | +11,034 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Sandia Investment Management LP | 0 | 10,000 | +10,000 | 0.00 | 0.31 | +0.31 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 9,828 | +9,828 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 9,047 | +9,047 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 0 | 8,660 | +8,660 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 7,590 | +7,590 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 3,200 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,846 | +2,846 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,822 | +1,822 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,734 | +1,734 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 1,660 | +1,660 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,511 | +1,511 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 1,290 | +1,290 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 594 | +594 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 249 | +249 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 134 | +134 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 12 | +12 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |