| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,086,413 | 7,518,202 | -568,211 | 0.01 | 0.01 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 5,693,589 | 5,693,589 | 0 | 2.57 | 3.16 | +0.59 | hold |
| BlackRock, Inc. | 2,603,706 | 3,344,504 | +740,798 | 0.00 | 0.00 | +0.00 | buy |
| Decheng Capital LLC | 3,285,293 | 3,143,078 | -142,215 | 10.78 | 11.48 | +0.70 | sell |
| NORGES BANK | 0 | 2,882,647 | +2,882,647 | 0.00 | 0.01 | +0.01 | buy |
| Enavate Sciences GP, LLC | 2,459,703 | 2,459,703 | 0 | 14.13 | 13.18 | -0.95 | hold |
| VANGUARD GROUP INC | 2,442,551 | 2,388,439 | -54,112 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 272,271 | 1,806,243 | +1,533,972 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,527,958 | +1,527,958 | 0.00 | 0.02 | +0.02 | buy |
| Altshuler Shaham Ltd | 1,416,822 | 1,341,540 | -75,282 | 0.44 | 0.56 | +0.12 | sell |
| Bain Capital Life Sciences Investors, LLC | 2,439,538 | 1,329,544 | -1,109,994 | 3.05 | 2.76 | -0.28 | sell |
| Omega Fund Management, LLC | 1,356,293 | 1,326,293 | -30,000 | 11.47 | 12.57 | +1.09 | sell |
| STATE STREET CORP | 1,114,581 | 1,319,226 | +204,645 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 1,169,298 | 1,169,298 | 0 | 1.24 | 1.57 | +0.33 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 1,125,395 | 894,733 | -230,662 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 817,109 | 851,908 | +34,799 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 843,502 | 834,559 | -8,943 | 1.74 | 2.16 | +0.41 | sell |
| Pictet Asset Management Holding SA | 0 | 773,148 | +773,148 | 0.00 | 0.02 | +0.02 | buy |
| Woodline Partners LP | 602,252 | 760,252 | +158,000 | 0.05 | 0.08 | +0.03 | buy |
| Integral Health Asset Management, LLC | 575,000 | 750,000 | +175,000 | 0.79 | 1.03 | +0.24 | buy |
| TCG Crossover Management, LLC | 2,117,103 | 743,886 | -1,373,217 | 1.96 | 0.67 | -1.29 | sell |
| Samsara BioCapital, LLC | 962,154 | 736,047 | -226,107 | 2.36 | 2.06 | -0.30 | sell |
| Vestal Point Capital, LP | 0 | 720,000 | +720,000 | 0.00 | 0.72 | +0.72 | buy |
| Siren, L.L.C. | 788,450 | 588,450 | -200,000 | 0.58 | 0.48 | -0.10 | sell |
| BARCLAYS PLC | 85,315 | 524,499 | +439,184 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 40,113 | 517,264 | +477,151 | 0.00 | 0.01 | +0.01 | buy |
| Nantahala Capital Management, LLC | 594,971 | 494,971 | -100,000 | 0.69 | 0.80 | +0.11 | sell |
| MARSHALL WACE, LLP | 867,999 | 343,791 | -524,208 | 0.02 | 0.01 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 223,214 | 333,481 | +110,267 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 300,000 | 300,000 | 0 | 2.36 | 2.64 | +0.28 | hold |
| Alyeska Investment Group, L.P. | 0 | 298,329 | +298,329 | 0.00 | 0.02 | +0.02 | buy |
| JENNISON ASSOCIATES LLC | 0 | 288,847 | +288,847 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 284,828 | 284,931 | +103 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 254,719 | 236,799 | -17,920 | 0.00 | 0.00 | +0.00 | sell |
| Invesco Ltd. | 17,190 | 163,186 | +145,996 | 0.00 | 0.00 | +0.00 | buy |
| Boxer Capital Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.89 | +0.89 | buy |
| DEUTSCHE BANK AG\ | 26,737 | 127,815 | +101,078 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 87,535 | 122,068 | +34,533 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 112,404 | 116,724 | +4,320 | 0.09 | 0.10 | +0.01 | buy |
| Schonfeld Strategic Advisors LLC | 190,244 | 115,807 | -74,437 | 0.02 | 0.02 | -0.01 | sell |
| JPMORGAN CHASE & CO | 29,947 | 110,280 | +80,333 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 71,540 | 87,756 | +16,216 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 55,473 | 86,384 | +30,911 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 91,521 | 84,853 | -6,668 | 0.00 | 0.00 | +0.00 | sell |
| Nuveen, LLC | 69,882 | 78,568 | +8,686 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 75,402 | +75,402 | 0.00 | 0.02 | +0.02 | buy |
| Artia Global Partners LP | 0 | 68,653 | +68,653 | 0.00 | 0.30 | +0.30 | buy |
| Exome Asset Management LLC | 51,960 | 64,845 | +12,885 | 0.65 | 0.87 | +0.22 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 56,557 | +56,557 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 55,841 | +55,841 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.10 | +0.10 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 46,559 | +46,559 | 0.00 | 0.03 | +0.03 | buy |
| ALPS ADVISORS INC | 25,962 | 44,376 | +18,414 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 49,406 | 41,523 | -7,883 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 34,521 | 38,683 | +4,162 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 25,160 | 36,794 | +11,634 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 31,049 | +31,049 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 19,850 | 31,010 | +11,160 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 29,954 | 30,503 | +549 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 27,091 | +27,091 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 26,600 | +26,600 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 0 | 20,500 | +20,500 | 0.00 | 0.33 | +0.33 | buy |
| MetLife Investment Management, LLC | 21,691 | 19,678 | -2,013 | 0.00 | 0.00 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 18,501 | 19,636 | +1,135 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,863 | 17,491 | +628 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 15,735 | 16,560 | +825 | 0.02 | 0.03 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 16,400 | +16,400 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 14,889 | 15,415 | +526 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 15,091 | +15,091 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,176 | 14,652 | +12,476 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 14,582 | +14,582 | 0.00 | 0.01 | +0.01 | buy |
| Graham Capital Management, L.P. | 0 | 13,712 | +13,712 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 2,924 | 13,709 | +10,785 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 13,420 | +13,420 | 0.00 | 0.00 | +0.00 | buy |
| DnB Asset Management AS | 0 | 12,793 | +12,793 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 12,246 | +12,246 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 47,001 | 12,020 | -34,981 | 0.01 | 0.00 | -0.00 | sell |
| Mariner, LLC | 10,933 | 11,830 | +897 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 14,266 | 11,749 | -2,517 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,300 | 11,700 | +5,400 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,500 | 10,500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| INTECH INVESTMENT MANAGEMENT LLC | 10,396 | 10,396 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,092 | 10,147 | -1,945 | 0.00 | 0.00 | +0.00 | sell |
| Virtus Investment Advisers, LLC | 9,843 | 9,801 | -42 | 0.05 | 0.07 | +0.02 | sell |
| STRS OHIO | 0 | 9,800 | +9,800 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 9,447 | 9,456 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 8,907 | +8,907 | 0.00 | 0.12 | +0.12 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 8,806 | +8,806 | 0.00 | 0.02 | +0.02 | buy |
| ProShare Advisors LLC | 0 | 8,354 | +8,354 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 8,087 | +8,087 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 42,037 | 6,949 | -35,088 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 0 | 5,518 | +5,518 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,527 | 4,976 | -1,551 | 0.00 | 0.00 | -0.00 | sell |
| CWM, LLC | 3,341 | 3,360 | +19 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 2,900 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 3,034 | 2,823 | -211 | 0.00 | 0.00 | +0.00 | sell |
| Ameritas Investment Partners, Inc. | 2,741 | 2,741 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Mirae Asset Global Investments Co., Ltd. | 0 | 2,626 | +2,626 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 2,264 | 1,919 | -345 | 0.00 | 0.00 | +0.00 | sell |
| Empowered Funds, LLC | 0 | 1,647 | +1,647 | 0.00 | 0.00 | +0.00 | buy |