| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 0 | 4,835,872 | +4,835,872 | 0.00 | 6.68 | +6.68 | buy |
| EcoR1 Capital, LLC | 0 | 4,824,469 | +4,824,469 | 0.00 | 3.69 | +3.69 | buy |
| Blue Owl Capital Holdings LP | 0 | 3,161,348 | +3,161,348 | 0.00 | 15.20 | +15.20 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 2,317,044 | +2,317,044 | 0.00 | 0.01 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 2,123,812 | +2,123,812 | 0.00 | 0.03 | +0.03 | buy |
| BlackRock, Inc. | 0 | 2,112,127 | +2,112,127 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 1,592,043 | +1,592,043 | 0.00 | 0.28 | +0.28 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 1,564,196 | +1,564,196 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 1,503,084 | +1,503,084 | 0.00 | 0.28 | +0.28 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 1,454,267 | +1,454,267 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 996,351 | +996,351 | 0.00 | 0.10 | +0.10 | buy |
| Octagon Capital Advisors LP | 0 | 960,847 | +960,847 | 0.00 | 1.90 | +1.90 | buy |
| Merck & Co., Inc. | 0 | 952,844 | +952,844 | 0.00 | 4.88 | +4.88 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 507,000 | +507,000 | 0.00 | 0.15 | +0.15 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 491,936 | +491,936 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 468,566 | +468,566 | 0.00 | 1.70 | +1.70 | buy |
| STATE STREET CORP | 0 | 428,253 | +428,253 | 0.00 | 0.00 | +0.00 | buy |
| AH Capital Management, L.L.C. | 0 | 415,000 | +415,000 | 0.00 | 0.58 | +0.58 | buy |
| FMR LLC | 0 | 386,379 | +386,379 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 353,263 | +353,263 | 0.00 | 0.00 | +0.00 | buy |
| ArrowMark Colorado Holdings LLC | 0 | 329,471 | +329,471 | 0.00 | 0.16 | +0.16 | buy |
| Alyeska Investment Group, L.P. | 0 | 290,000 | +290,000 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 162,017 | +162,017 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 150,000 | +150,000 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 0 | 149,476 | +149,476 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 102,925 | +102,925 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 100,962 | +100,962 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.02 | +0.02 | buy |
| Laurion Capital Management LP | 0 | 100,000 | +100,000 | 0.00 | 0.17 | +0.17 | buy |
| Woodline Partners LP | 0 | 100,000 | +100,000 | 0.00 | 0.01 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 75,000 | +75,000 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 69,926 | +69,926 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 46,993 | +46,993 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 42,901 | +42,901 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 30,163 | +30,163 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 30,000 | +30,000 | 0.00 | 0.03 | +0.03 | buy |
| Ghisallo Capital Management LLC | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 25,000 | +25,000 | 0.00 | 0.03 | +0.03 | buy |
| Nuveen, LLC | 0 | 24,468 | +24,468 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 21,033 | +21,033 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 0 | 17,062 | +17,062 | 0.00 | 0.00 | +0.00 | buy |
| Zimmer Partners, LP | 0 | 15,000 | +15,000 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 14,185 | +14,185 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 14,080 | +14,080 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 13,990 | +13,990 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 12,113 | +12,113 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 11,637 | +11,637 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 9,724 | +9,724 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 9,651 | +9,651 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 0 | 8,355 | +8,355 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 7,611 | +7,611 | 0.00 | 0.00 | +0.00 | buy |
| PNC FINANCIAL SERVICES GROUP, INC. | 0 | 6,948 | +6,948 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 5,530 | +5,530 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 4,480 | +4,480 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 3,600 | +3,600 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 3,200 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,826 | +1,826 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,683 | +1,683 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,551 | +1,551 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 1,019 | +1,019 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 1,009 | +1,009 | 0.00 | 0.00 | +0.00 | buy |
| SALEM INVESTMENT COUNSELORS INC | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 393 | +393 | 0.00 | 0.00 | +0.00 | buy |