| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| TCG Crossover Management, LLC | 0 | 696,560 | +696,560 | 0.00 | 0.54 | +0.54 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 166,842 | +166,842 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 2,112,127 | 2,278,358 | +166,231 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 9,724 | 151,696 | +141,972 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 95,400 | +95,400 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 63,514 | +63,514 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 0 | 62,636 | +62,636 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 0 | 57,059 | +57,059 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 428,253 | 484,010 | +55,757 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 50,464 | +50,464 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 48,123 | +48,123 | 0.00 | 0.00 | +0.00 | buy |
| Quantinno Capital Management LP | 0 | 46,887 | +46,887 | 0.00 | 0.00 | +0.00 | buy |
| GREAT LAKES ADVISORS, LLC | 0 | 43,612 | +43,612 | 0.00 | 0.01 | +0.01 | buy |
| Mirador Capital Partners LP | 0 | 40,124 | +40,124 | 0.00 | 0.16 | +0.16 | buy |
| Squarepoint Ops LLC | 0 | 38,381 | +38,381 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 32,779 | +32,779 | 0.00 | 0.01 | +0.01 | buy |
| Sofinnova Investments, Inc. | 0 | 32,436 | +32,436 | 0.00 | 0.06 | +0.06 | buy |
| NORTHERN TRUST CORP | 149,476 | 180,575 | +31,099 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 30,914 | +30,914 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 491,936 | 520,737 | +28,801 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 24,468 | 49,816 | +25,348 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 21,402 | +21,402 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 7,611 | 27,659 | +20,048 | 0.00 | 0.00 | +0.00 | buy |
| Mariner, LLC | 0 | 17,770 | +17,770 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 16,402 | +16,402 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 468,566 | 484,200 | +15,634 | 1.70 | 2.50 | +0.80 | buy |
| Virtus Investment Advisers, LLC | 0 | 14,920 | +14,920 | 0.00 | 0.11 | +0.11 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 14,379 | +14,379 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 1,019 | 13,177 | +12,158 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 7,020 | +7,020 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 14,080 | 21,022 | +6,942 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 42,901 | 49,250 | +6,349 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 1,551 | 7,754 | +6,203 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 21,033 | 26,945 | +5,912 | 0.00 | 0.00 | +0.00 | buy |
| NBC SECURITIES, INC. | 0 | 5,358 | +5,358 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 100,962 | 105,902 | +4,940 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 162,017 | 166,842 | +4,825 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,200 | 7,500 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 3,368 | +3,368 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 2,978 | +2,978 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 69,926 | 72,835 | +2,909 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 12,113 | 14,908 | +2,795 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 2,267 | +2,267 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 11,637 | 12,994 | +1,357 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,009 | 2,268 | +1,259 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 46,993 | 48,044 | +1,051 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 985 | +985 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 700 | +700 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 576 | +576 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 8,355 | 8,835 | +480 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 397 | +397 | 0.00 | 0.00 | +0.00 | buy |
| Global Retirement Partners, LLC | 0 | 395 | +395 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 385 | +385 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 310 | +310 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 288 | +288 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,683 | 1,925 | +242 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,826 | 2,062 | +236 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 124 | +124 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,651 | 9,769 | +118 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 101 | +101 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 80 | +80 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 77 | +77 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 39 | +39 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 34 | +34 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| WPG Advisers, LLC | 0 | 25 | +25 | 0.00 | 0.00 | +0.00 | buy |
| FWL INVESTMENT MANAGEMENT, LLC | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| Rossby Financial, LCC | 0 | 18 | +18 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| Freestone Grove Partners LP | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 100,000 | 100,000 | 0 | 0.02 | 0.04 | +0.02 | hold |
| BAKER BROS. ADVISORS LP | 996,351 | 996,351 | 0 | 0.10 | 0.16 | +0.06 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 507,000 | 507,000 | 0 | 0.15 | 0.22 | +0.07 | hold |
| Alyeska Investment Group, L.P. | 290,000 | 290,000 | 0 | 0.01 | 0.02 | +0.01 | hold |
| RTW INVESTMENTS, LP | 1,592,043 | 1,592,043 | 0 | 0.28 | 0.44 | +0.15 | hold |
| AH Capital Management, L.L.C. | 415,000 | 415,000 | 0 | 0.58 | 0.09 | -0.48 | hold |
| EcoR1 Capital, LLC | 4,824,469 | 4,824,469 | 0 | 3.69 | 7.71 | +4.02 | hold |
| MPM BioImpact LLC | 4,835,872 | 4,835,872 | 0 | 6.68 | 9.50 | +2.82 | hold |
| Woodline Partners LP | 100,000 | 100,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ghisallo Capital Management LLC | 25,000 | 25,000 | 0 | 0.01 | 0.02 | +0.00 | hold |
| Octagon Capital Advisors LP | 960,847 | 960,847 | 0 | 1.90 | 2.84 | +0.94 | hold |
| READYSTATE ASSET MANAGEMENT LP | 30,000 | 30,000 | 0 | 0.03 | 0.04 | +0.01 | hold |
| SEVEN GRAND MANAGERS, LLC | 25,000 | 25,000 | 0 | 0.03 | 0.03 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 5,530 | 5,530 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Merck & Co., Inc. | 952,844 | 952,844 | 0 | 4.88 | 5.83 | +0.96 | hold |
| SALEM INVESTMENT COUNSELORS INC | 1,000 | 1,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Sterling Capital Management LLC | 393 | 184 | -209 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 3,600 | 3,100 | -500 | 0.00 | 0.00 | +0.00 | sell |
| PNC FINANCIAL SERVICES GROUP, INC. | 6,948 | 6,140 | -808 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,480 | 3,280 | -1,200 | 0.00 | 0.00 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 30,163 | 21,278 | -8,885 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 13,990 | 0 | -13,990 | 0.00 | 0.00 | -0.00 | sell |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 14,185 | 0 | -14,185 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 15,000 | 0 | -15,000 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 17,062 | 0 | -17,062 | 0.00 | 0.00 | -0.00 | sell |