| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 10,445,322 | +10,445,322 | 0.00 | 1.82 | +1.82 | buy |
| TPG GP A, LLC | 0 | 6,684,962 | +6,684,962 | 0.00 | 1.41 | +1.41 | buy |
| ORBIMED ADVISORS LLC | 0 | 3,704,959 | +3,704,959 | 0.00 | 0.93 | +0.93 | buy |
| Atlas Venture Life Science Advisors, LLC | 0 | 3,694,020 | +3,694,020 | 0.00 | 7.41 | +7.41 | buy |
| VIKING GLOBAL INVESTORS LP | 0 | 2,952,754 | +2,952,754 | 0.00 | 0.10 | +0.10 | buy |
| Enavate Sciences GP, LLC | 0 | 2,478,030 | +2,478,030 | 0.00 | 19.53 | +19.53 | buy |
| JPMORGAN CHASE & CO | 0 | 2,169,599 | +2,169,599 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,251,101 | +1,251,101 | 0.00 | 0.46 | +0.46 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 996,212 | +996,212 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 0 | 859,927 | +859,927 | 0.00 | 0.01 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 0 | 747,000 | +747,000 | 0.00 | 0.15 | +0.15 | buy |
| Aberdeen Group plc | 0 | 745,964 | +745,964 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 0 | 546,167 | +546,167 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 500,023 | +500,023 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 0 | 400,000 | +400,000 | 0.00 | 0.05 | +0.05 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 328,889 | +328,889 | 0.00 | 0.03 | +0.03 | buy |
| CITADEL ADVISORS LLC | 0 | 326,500 | +326,500 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 0 | 325,000 | +325,000 | 0.00 | 0.19 | +0.19 | buy |
| Soleus Capital Management, L.P. | 0 | 240,000 | +240,000 | 0.00 | 0.20 | +0.20 | buy |
| Zimmer Partners, LP | 0 | 237,500 | +237,500 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 209,266 | +209,266 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 0 | 198,396 | +198,396 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 0 | 186,222 | +186,222 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 179,072 | +179,072 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 135,563 | +135,563 | 0.00 | 0.00 | +0.00 | buy |
| CenterBook Partners LP | 0 | 114,284 | +114,284 | 0.00 | 0.08 | +0.08 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 114,138 | +114,138 | 0.00 | 0.25 | +0.25 | buy |
| Rock Springs Capital Management LP | 0 | 99,429 | +99,429 | 0.00 | 0.06 | +0.06 | buy |
| Woodline Partners LP | 0 | 80,000 | +80,000 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 64,644 | +64,644 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 63,741 | +63,741 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 63,000 | +63,000 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 0 | 60,000 | +60,000 | 0.00 | 0.20 | +0.20 | buy |
| TD ASSET MANAGEMENT INC | 0 | 55,366 | +55,366 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 33,964 | +33,964 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 33,549 | +33,549 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 26,822 | +26,822 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 14,757 | +14,757 | 0.00 | 0.04 | +0.04 | buy |
| STATE STREET CORP | 0 | 14,400 | +14,400 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 13,060 | +13,060 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 12,188 | +12,188 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 11,715 | +11,715 | 0.00 | 0.00 | +0.00 | buy |