| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,905,045 | 9,905,045 | 0 | 4.17 | 4.21 | +0.03 | hold |
| TPG GP A, LLC | 6,744,962 | 6,494,962 | -250,000 | 10.33 | 7.08 | -3.25 | sell |
| ORBIMED ADVISORS LLC | 3,561,655 | 3,530,702 | -30,953 | 3.00 | 3.09 | +0.09 | sell |
| VIKING GLOBAL INVESTORS LP | 3,195,181 | 3,195,181 | 0 | 0.35 | 0.36 | +0.01 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,995,602 | 2,995,602 | 0 | 14.24 | 15.20 | +0.96 | hold |
| Enavate Sciences GP, LLC | 2,478,030 | 2,478,030 | 0 | 20.12 | 28.26 | +8.15 | hold |
| JPMORGAN CHASE & CO | 1,231,819 | 1,465,014 | +233,195 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 1,115,278 | 1,451,220 | +335,942 | 0.03 | 0.04 | +0.01 | buy |
| BlackRock, Inc. | 1,291,599 | 1,295,867 | +4,268 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 1,087,325 | 1,166,931 | +79,606 | 0.03 | 0.03 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 970,590 | 970,590 | 0 | 0.51 | 0.46 | -0.05 | hold |
| PRICE T ROWE ASSOCIATES INC /MD/ | 831,373 | 756,376 | -74,997 | 0.00 | 0.00 | -0.00 | sell |
| STATE STREET CORP | 693,395 | 756,227 | +62,832 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 1,179,098 | 658,439 | -520,659 | 0.89 | 0.52 | -0.37 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 639,045 | 645,530 | +6,485 | 0.41 | 0.43 | +0.02 | buy |
| Aberdeen Group plc | 839,960 | 564,175 | -275,785 | 0.05 | 0.04 | -0.02 | sell |
| BAKER BROS. ADVISORS LP | 400,000 | 400,000 | 0 | 0.10 | 0.09 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 380,042 | 389,872 | +9,830 | 0.00 | 0.00 | +0.00 | buy |
| Siren, L.L.C. | 300,000 | 300,000 | 0 | 0.37 | 0.33 | -0.03 | hold |
| Sio Capital Management, LLC | 0 | 294,340 | +294,340 | 0.00 | 1.70 | +1.70 | buy |
| Soleus Capital Management, L.P. | 268,500 | 293,500 | +25,000 | 0.47 | 0.48 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 36,269 | 263,174 | +226,905 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 79,862 | 255,636 | +175,774 | 0.01 | 0.02 | +0.01 | buy |
| Candriam S.C.A. | 0 | 236,813 | +236,813 | 0.00 | 0.05 | +0.05 | buy |
| FRANKLIN RESOURCES INC | 175,483 | 175,483 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 150,000 | +150,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 89,177 | 147,641 | +58,464 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 180,593 | 141,024 | -39,569 | 3.98 | 4.04 | +0.06 | sell |
| MILLENNIUM MANAGEMENT LLC | 80,546 | 140,641 | +60,095 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 136,549 | +136,549 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 136,222 | 136,222 | 0 | 0.02 | 0.02 | -0.00 | hold |
| MORGAN STANLEY | 49,876 | 133,023 | +83,147 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 123,686 | 120,253 | -3,433 | 0.00 | 0.00 | -0.00 | sell |
| Artia Global Partners LP | 119,741 | 119,741 | 0 | 0.79 | 1.08 | +0.29 | hold |
| NORTHERN TRUST CORP | 112,116 | 116,776 | +4,660 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 99,429 | 99,429 | 0 | 0.21 | 0.23 | +0.03 | hold |
| Rhenman & Partners Asset Management AB | 0 | 87,500 | +87,500 | 0.00 | 0.43 | +0.43 | buy |
| TD ASSET MANAGEMENT INC | 113,352 | 82,996 | -30,356 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 101,643 | 81,974 | -19,669 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 384 | 81,395 | +81,011 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 83,850 | 76,633 | -7,217 | 0.02 | 0.02 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 69,424 | 64,458 | -4,966 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 43,567 | 50,870 | +7,303 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.11 | +0.11 | buy |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 50,000 | 0 | 0.16 | 0.13 | -0.02 | hold |
| Russell Investments Group, Ltd. | 21,941 | 48,419 | +26,478 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 38,347 | 46,079 | +7,732 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 42,242 | +42,242 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,264 | 40,570 | +38,306 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 41,460 | 39,417 | -2,043 | 0.25 | 0.19 | -0.06 | sell |
| ALPS ADVISORS INC | 36,648 | 36,628 | -20 | 0.01 | 0.01 | -0.00 | sell |
| STEMPOINT CAPITAL LP | 0 | 36,540 | +36,540 | 0.00 | 0.28 | +0.28 | buy |
| Bank of New York Mellon Corp | 35,134 | 33,778 | -1,356 | 0.00 | 0.00 | -0.00 | sell |
| POLEN CAPITAL MANAGEMENT LLC | 31,258 | 26,775 | -4,483 | 0.01 | 0.01 | +0.00 | sell |
| Maven Securities LTD | 0 | 25,000 | +25,000 | 0.00 | 0.06 | +0.06 | buy |
| Nuveen, LLC | 23,734 | 23,734 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 4,926 | 23,551 | +18,625 | 0.01 | 0.02 | +0.01 | buy |
| Rafferty Asset Management, LLC | 24,690 | 22,137 | -2,553 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 48,172 | 18,385 | -29,787 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 17,694 | 18,308 | +614 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,185 | 18,058 | +12,873 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 15,620 | 16,410 | +790 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 16,360 | 15,217 | -1,143 | 0.00 | 0.00 | -0.00 | sell |
| Walleye Capital LLC | 0 | 15,097 | +15,097 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 10,029 | 13,249 | +3,220 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 79,729 | 12,693 | -67,036 | 0.39 | 0.02 | -0.37 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 6,752 | 12,284 | +5,532 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 111,162 | 10,787 | -100,375 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 9,213 | 9,939 | +726 | 0.01 | 0.01 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 8,915 | 9,185 | +270 | 0.00 | 0.00 | -0.00 | buy |
| MetLife Investment Management, LLC | 8,565 | 8,565 | 0 | 0.00 | 0.00 | +0.00 | hold |
| China Universal Asset Management Co., Ltd. | 10,272 | 7,920 | -2,352 | 0.03 | 0.02 | -0.01 | sell |
| ExodusPoint Capital Management, LP | 0 | 7,190 | +7,190 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 6,220 | 6,374 | +154 | 0.07 | 0.07 | +0.00 | buy |
| Quarry LP | 0 | 6,304 | +6,304 | 0.00 | 0.05 | +0.05 | buy |
| Hudson Bay Capital Management LP | 0 | 6,180 | +6,180 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 17,551 | 5,894 | -11,657 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 6,400 | 5,500 | -900 | 0.00 | 0.00 | -0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 7,589 | 5,489 | -2,100 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,300 | 5,300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 4,232 | 4,232 | 0 | 0.00 | 0.00 | +0.00 | hold |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 5,189 | 4,116 | -1,073 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 0 | 2,900 | +2,900 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 1,129 | 2,352 | +1,223 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,169 | 2,328 | +159 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,682 | 1,432 | -250 | 0.00 | 0.00 | -0.00 | sell |
| Ameritas Investment Partners, Inc. | 1,302 | 1,302 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GF FUND MANAGEMENT CO. LTD. | 876 | 1,003 | +127 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 988 | 868 | -120 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 371 | +371 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 254 | +254 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 48 | 241 | +193 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 177 | 238 | +61 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 190 | 196 | +6 | 0.00 | 0.00 | -0.00 | buy |
| Quantbot Technologies LP | 0 | 178 | +178 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 116 | +116 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 105 | 105 | 0 | 0.00 | 0.00 | +0.00 | hold |
| US BANCORP \DE\ | 65 | 51 | -14 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 0 | 36 | +36 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 28 | 29 | +1 | 0.00 | 0.00 | -0.00 | buy |