| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BRAIDWELL LP | 0 | 1,081,855 | +1,081,855 | 0.00 | 0.64 | +0.64 | buy |
| BlackRock, Inc. | 198,396 | 637,104 | +438,708 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 2,952,754 | 3,195,181 | +242,427 | 0.10 | 0.16 | +0.06 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 747,000 | 970,590 | +223,590 | 0.15 | 0.31 | +0.15 | buy |
| Aberdeen Group plc | 745,964 | 950,547 | +204,583 | 0.02 | 0.03 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 135,563 | 289,275 | +153,712 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 240,000 | 376,000 | +136,000 | 0.20 | 0.45 | +0.25 | buy |
| STATE STREET CORP | 14,400 | 124,518 | +110,118 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 546,167 | 630,351 | +84,184 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 63,000 | 135,185 | +72,185 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 114,138 | 186,015 | +71,877 | 0.25 | 0.66 | +0.41 | buy |
| NORTHERN TRUST CORP | 26,822 | 91,890 | +65,068 | 0.00 | 0.00 | +0.00 | buy |
| TPG GP A, LLC | 6,684,962 | 6,744,962 | +60,000 | 1.41 | 6.24 | +4.83 | buy |
| JPMORGAN CHASE & CO | 2,169,599 | 2,221,188 | +51,589 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 51,367 | +51,367 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 64,644 | 92,832 | +28,188 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 209,266 | 236,813 | +27,547 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 26,000 | +26,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 0 | 24,131 | +24,131 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 23,022 | +23,022 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 17,670 | +17,670 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 16,975 | +16,975 | 0.00 | 0.00 | +0.00 | buy |
| BOSUN ASSET MANAGEMENT, LLC | 0 | 16,975 | +16,975 | 0.00 | 0.11 | +0.11 | buy |
| Nuveen, LLC | 0 | 16,040 | +16,040 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 14,017 | +14,017 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 9,596 | +9,596 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 8,033 | +8,033 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 6,800 | +6,800 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 6,747 | +6,747 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 6,374 | +6,374 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 5,535 | +5,535 | 0.00 | 0.03 | +0.03 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,549 | 38,038 | +4,489 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 4,380 | +4,380 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 2,608 | +2,608 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 1,761 | +1,761 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 1,374 | +1,374 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 1,259 | +1,259 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 770 | +770 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 0 | 421 | +421 | 0.00 | 0.00 | +0.00 | buy |
| Hughes Financial Services, LLC | 0 | 44 | +44 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 3,704,959 | 3,704,959 | 0 | 0.93 | 1.62 | +0.69 | hold |
| BAKER BROS. ADVISORS LP | 400,000 | 400,000 | 0 | 0.05 | 0.07 | +0.02 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,445,322 | 10,445,322 | 0 | 1.82 | 3.05 | +1.23 | hold |
| Alyeska Investment Group, L.P. | 186,222 | 186,222 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Rock Springs Capital Management LP | 99,429 | 99,429 | 0 | 0.06 | 0.11 | +0.05 | hold |
| Holocene Advisors, LP | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Woodline Partners LP | 80,000 | 80,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Atlas Venture Life Science Advisors, LLC | 3,694,020 | 3,694,020 | 0 | 7.41 | 9.68 | +2.27 | hold |
| Enavate Sciences GP, LLC | 2,478,030 | 2,478,030 | 0 | 19.53 | 24.35 | +4.82 | hold |
| Siren, L.L.C. | 325,000 | 325,000 | 0 | 0.19 | 0.29 | +0.10 | hold |
| FRANKLIN RESOURCES INC | 500,023 | 500,023 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 55,366 | 49,966 | -5,400 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 11,715 | 0 | -11,715 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 12,188 | 0 | -12,188 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 13,060 | 0 | -13,060 | 0.00 | 0.00 | -0.00 | sell |
| Aster Capital Management (DIFC) Ltd | 14,757 | 0 | -14,757 | 0.04 | 0.00 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 63,741 | 46,048 | -17,693 | 0.00 | 0.00 | +0.00 | sell |
| Squarepoint Ops LLC | 33,964 | 0 | -33,964 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,251,101 | 1,216,045 | -35,056 | 0.46 | 0.79 | +0.33 | sell |
| STEMPOINT CAPITAL LP | 60,000 | 0 | -60,000 | 0.20 | 0.00 | -0.20 | sell |
| JENNISON ASSOCIATES LLC | 859,927 | 752,800 | -107,127 | 0.01 | 0.01 | +0.00 | sell |
| CenterBook Partners LP | 114,284 | 0 | -114,284 | 0.08 | 0.00 | -0.08 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 996,212 | 861,238 | -134,974 | 0.00 | 0.00 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 179,072 | 14,034 | -165,038 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 326,500 | 129,912 | -196,588 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 237,500 | 0 | -237,500 | 0.05 | 0.00 | -0.05 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 328,889 | 83,850 | -245,039 | 0.03 | 0.01 | -0.02 | sell |