| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 1,600,000 | +1,450,000 | 0.01 | 0.10 | +0.09 | buy |
| Casdin Capital, LLC | 0 | 400,000 | +400,000 | 0.00 | 0.88 | +0.88 | buy |
| Siren, L.L.C. | 300,000 | 610,515 | +310,515 | 0.33 | 0.55 | +0.21 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 76,633 | 385,447 | +308,814 | 0.02 | 0.10 | +0.08 | buy |
| STATE STREET CORP | 756,227 | 1,021,534 | +265,307 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 658,439 | 905,000 | +246,561 | 0.52 | 0.62 | +0.10 | buy |
| FMR LLC | 81,395 | 278,292 | +196,897 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 189,498 | +189,498 | 0.00 | 0.01 | +0.01 | buy |
| Longaeva Partners L.P. | 12,693 | 196,352 | +183,659 | 0.02 | 0.25 | +0.22 | buy |
| BlackRock, Inc. | 1,295,867 | 1,474,769 | +178,902 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 0 | 144,432 | +144,432 | 0.00 | 0.34 | +0.34 | buy |
| MILLENNIUM MANAGEMENT LLC | 140,641 | 276,733 | +136,092 | 0.00 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 129,753 | +129,753 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 263,174 | 388,810 | +125,636 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 175,483 | 290,113 | +114,630 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 0 | 110,493 | +110,493 | 0.00 | 0.52 | +0.52 | buy |
| D. E. Shaw & Co., Inc. | 0 | 101,644 | +101,644 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 42,242 | 140,309 | +98,067 | 0.00 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 18,058 | 110,163 | +92,105 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 15,097 | 97,347 | +82,250 | 0.00 | 0.02 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 389,872 | 457,145 | +67,273 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 13,249 | 53,353 | +40,104 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 50,870 | 88,908 | +38,038 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 116,776 | 154,476 | +37,700 | 0.00 | 0.00 | +0.00 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 35,968 | +35,968 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 0 | 27,000 | +27,000 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 26,023 | +26,023 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 1,465,014 | 1,490,508 | +25,494 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 50,000 | 75,000 | +25,000 | 0.11 | 0.14 | +0.03 | buy |
| Trexquant Investment LP | 0 | 23,810 | +23,810 | 0.00 | 0.01 | +0.01 | buy |
| STEMPOINT CAPITAL LP | 36,540 | 59,426 | +22,886 | 0.28 | 0.45 | +0.17 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 22,575 | +22,575 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 5,300 | 23,586 | +18,286 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 18,034 | +18,034 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 133,023 | 151,047 | +18,024 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 18,000 | +18,000 | 0.00 | 0.09 | +0.09 | buy |
| Nuveen, LLC | 23,734 | 41,259 | +17,525 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 15,603 | +15,603 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 23,551 | 38,096 | +14,545 | 0.02 | 0.02 | +0.01 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 4,116 | 18,645 | +14,529 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 868 | 14,852 | +13,984 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 12,599 | +12,599 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 5,894 | 16,821 | +10,927 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 116 | 10,622 | +10,506 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 10,473 | +10,473 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 87,500 | 97,100 | +9,600 | 0.43 | 0.40 | -0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,253 | 129,753 | +9,500 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 16,410 | 25,450 | +9,040 | 0.00 | 0.00 | +0.00 | buy |
| ALPS ADVISORS INC | 36,628 | 45,525 | +8,897 | 0.01 | 0.01 | +0.00 | buy |
| Bank of New York Mellon Corp | 33,778 | 41,586 | +7,808 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,432 | 9,044 | +7,612 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 5,215 | +5,215 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 5,158 | +5,158 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 4,780 | +4,780 | 0.00 | 0.00 | +0.00 | buy |
| AXQ CAPITAL, LP | 0 | 4,597 | +4,597 | 0.00 | 0.02 | +0.02 | buy |
| RHUMBLINE ADVISERS | 18,308 | 22,309 | +4,001 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 3,100 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 39,417 | 42,478 | +3,061 | 0.19 | 0.21 | +0.02 | buy |
| Virtus Investment Advisers, LLC | 6,374 | 9,109 | +2,735 | 0.07 | 0.09 | +0.02 | buy |
| MetLife Investment Management, LLC | 8,565 | 10,972 | +2,407 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 178 | 1,820 | +1,642 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 10,787 | 12,418 | +1,631 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 9,185 | 10,582 | +1,397 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 4,232 | 5,438 | +1,206 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 0 | 804 | +804 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 2,900 | 3,500 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 6,304 | 6,750 | +446 | 0.05 | 0.05 | -0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 385 | +385 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 1,302 | 1,673 | +371 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 371 | 709 | +338 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 12,284 | 12,621 | +337 | 0.01 | 0.01 | -0.00 | buy |
| Pacer Advisors, Inc. | 0 | 301 | +301 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 81,974 | 82,232 | +258 | 0.00 | 0.00 | -0.00 | buy |
| Federation des caisses Desjardins du Quebec | 0 | 210 | +210 | 0.00 | 0.00 | +0.00 | buy |
| Hurley Capital, LLC | 0 | 113 | +113 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 51 | 104 | +53 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 41 | +41 | 0.00 | 0.00 | +0.00 | buy |
| Bare Financial Services, Inc | 0 | 37 | +37 | 0.00 | 0.00 | +0.00 | buy |
| SJS Investment Consulting Inc. | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 3 | 12 | +9 | 0.00 | 0.00 | +0.00 | buy |
| CONTRAVISORY INVESTMENT MANAGEMENT, INC. | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 238 | 244 | +6 | 0.00 | 0.00 | -0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2 | +2 | 0.00 | 0.00 | +0.00 | buy |
| VIKING GLOBAL INVESTORS LP | 3,195,181 | 3,195,181 | 0 | 0.36 | 0.40 | +0.04 | hold |
| BAKER BROS. ADVISORS LP | 400,000 | 400,000 | 0 | 0.09 | 0.09 | -0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 9,905,045 | 9,905,045 | 0 | 4.21 | 3.79 | -0.42 | hold |
| Alyeska Investment Group, L.P. | 136,222 | 136,222 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Rock Springs Capital Management LP | 99,429 | 99,429 | 0 | 0.23 | 0.21 | -0.02 | hold |
| TPG GP A, LLC | 6,494,962 | 6,494,962 | 0 | 7.08 | 5.71 | -1.37 | hold |
| SEVEN GRAND MANAGERS, LLC | 50,000 | 50,000 | 0 | 0.13 | 0.09 | -0.05 | hold |
| Atlas Venture Life Science Advisors, LLC | 2,995,602 | 2,995,602 | 0 | 15.20 | 14.95 | -0.25 | hold |
| Artia Global Partners LP | 119,741 | 119,741 | 0 | 1.08 | 1.00 | -0.08 | hold |
| Fortitude Family Office, LLC | 15 | 15 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Enavate Sciences GP, LLC | 2,478,030 | 2,478,030 | 0 | 28.26 | 31.56 | +3.30 | hold |
| Farther Finance Advisors, LLC | 196 | 196 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ROTHSCHILD INVESTMENT LLC | 1 | 1 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Hughes Financial Services, LLC | 26 | 25 | -1 | 0.00 | 0.00 | -0.00 | sell |
| MAI Capital Management | 2 | 0 | -2 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 23 | 20 | -3 | 0.00 | 0.00 | +0.00 | sell |