| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| VANGUARD GROUP INC | 630,351 | 1,143,154 | +512,803 | 0.00 | 0.00 | +0.00 | buy |
| JENNISON ASSOCIATES LLC | 752,800 | 997,375 | +244,575 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 637,104 | 844,605 | +207,501 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,034 | 214,085 | +200,051 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 124,518 | 240,199 | +115,681 | 0.00 | 0.00 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 61,457 | +61,457 | 0.00 | 0.38 | +0.38 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 42,234 | +42,234 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 376,000 | 413,500 | +37,500 | 0.45 | 0.65 | +0.20 | buy |
| TD ASSET MANAGEMENT INC | 49,966 | 87,082 | +37,116 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 30,103 | +30,103 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 289,275 | 316,564 | +27,289 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 92,832 | 111,496 | +18,664 | 0.00 | 0.00 | +0.00 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 16,975 | 31,258 | +14,283 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 10,162 | +10,162 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 8,513 | +8,513 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 7,486 | +7,486 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 1,374 | 7,374 | +6,000 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 91,890 | 97,711 | +5,821 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 0 | 4,490 | +4,490 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 24,131 | 27,463 | +3,332 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 6,374 | 7,576 | +1,202 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 5,535 | 6,698 | +1,163 | 0.03 | 0.06 | +0.02 | buy |
| Russell Investments Group, Ltd. | 0 | 1,022 | +1,022 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 2,608 | 3,234 | +626 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,761 | 2,380 | +619 | 0.00 | 0.00 | +0.00 | buy |
| Aster Capital Management (DIFC) Ltd | 0 | 409 | +409 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 0 | 234 | +234 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 153 | +153 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 113 | +113 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 111 | +111 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 92 | +92 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 22 | +22 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 770 | 771 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 970,590 | 970,590 | 0 | 0.31 | 0.44 | +0.13 | hold |
| ORBIMED ADVISORS LLC | 3,704,959 | 3,704,959 | 0 | 1.62 | 2.61 | +1.00 | hold |
| Ameritas Investment Partners, Inc. | 1,259 | 1,259 | 0 | 0.00 | 0.00 | +0.00 | hold |
| VIKING GLOBAL INVESTORS LP | 3,195,181 | 3,195,181 | 0 | 0.16 | 0.24 | +0.08 | hold |
| BAKER BROS. ADVISORS LP | 400,000 | 400,000 | 0 | 0.07 | 0.09 | +0.02 | hold |
| Sterling Capital Management LLC | 30 | 30 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 10,445,322 | 10,445,322 | 0 | 3.05 | 3.79 | +0.73 | hold |
| Alyeska Investment Group, L.P. | 186,222 | 186,222 | 0 | 0.01 | 0.02 | +0.01 | hold |
| MetLife Investment Management, LLC | 8,033 | 8,033 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rock Springs Capital Management LP | 99,429 | 99,429 | 0 | 0.11 | 0.17 | +0.06 | hold |
| Holocene Advisors, LP | 50,000 | 50,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Aberdeen Group plc | 950,547 | 950,547 | 0 | 0.03 | 0.04 | +0.02 | hold |
| Nuveen, LLC | 16,040 | 16,040 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TPG GP A, LLC | 6,744,962 | 6,744,962 | 0 | 6.24 | 10.80 | +4.57 | hold |
| Enavate Sciences GP, LLC | 2,478,030 | 2,478,030 | 0 | 24.35 | 22.25 | -2.10 | hold |
| Siren, L.L.C. | 325,000 | 325,000 | 0 | 0.29 | 0.37 | +0.08 | hold |
| Hughes Financial Services, LLC | 44 | 44 | 0 | 0.00 | 0.00 | +0.00 | hold |
| AMALGAMATED BANK | 421 | 421 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 83,850 | 83,850 | 0 | 0.01 | 0.02 | +0.01 | hold |
| DEUTSCHE BANK AG\ | 9,596 | 9,596 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 17,670 | 17,240 | -430 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 6,747 | 5,643 | -1,104 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 6,800 | 5,300 | -1,500 | 0.00 | 0.00 | +0.00 | sell |
| STRS OHIO | 2,300 | 0 | -2,300 | 0.00 | 0.00 | -0.00 | sell |
| CITIGROUP INC | 4,380 | 687 | -3,693 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 51,367 | 46,666 | -4,701 | 0.00 | 0.00 | +0.00 | sell |
| BARCLAYS PLC | 23,022 | 17,643 | -5,379 | 0.00 | 0.00 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,038 | 32,080 | -5,958 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 26,000 | 14,600 | -11,400 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 14,017 | 0 | -14,017 | 0.00 | 0.00 | -0.00 | sell |
| BOSUN ASSET MANAGEMENT, LLC | 16,975 | 0 | -16,975 | 0.11 | 0.00 | -0.11 | sell |
| GOLDMAN SACHS GROUP INC | 46,048 | 12,178 | -33,870 | 0.00 | 0.00 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 1,216,045 | 1,179,098 | -36,947 | 0.79 | 1.00 | +0.21 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 186,015 | 108,801 | -77,214 | 0.66 | 0.46 | -0.20 | sell |
| Atlas Venture Life Science Advisors, LLC | 3,694,020 | 3,615,527 | -78,493 | 9.68 | 14.13 | +4.45 | sell |
| Woodline Partners LP | 80,000 | 0 | -80,000 | 0.01 | 0.00 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 236,813 | 153,151 | -83,662 | 0.00 | 0.00 | +0.00 | sell |
| CITADEL ADVISORS LLC | 129,912 | 35,923 | -93,989 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 135,185 | 0 | -135,185 | 0.00 | 0.00 | -0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 861,238 | 637,760 | -223,478 | 0.00 | 0.00 | +0.00 | sell |
| JPMORGAN CHASE & CO | 2,221,188 | 1,978,626 | -242,562 | 0.00 | 0.00 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 500,023 | 242,147 | -257,876 | 0.00 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 1,081,855 | 314,013 | -767,842 | 0.64 | 0.27 | -0.37 | sell |