| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 113,022 | 1,455,863 | +1,342,841 | 0.22 | 2.58 | +2.36 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 961,525 | 1,209,129 | +247,604 | 0.26 | 0.46 | +0.20 | buy |
| RTW INVESTMENTS, LP | 1,283,671 | 1,502,235 | +218,564 | 0.22 | 0.34 | +0.12 | buy |
| Integral Health Asset Management, LLC | 125,000 | 225,000 | +100,000 | 0.11 | 0.27 | +0.17 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 3,458,770 | 3,494,638 | +35,868 | 0.61 | 0.85 | +0.24 | buy |
| Monashee Investment Management LLC | 183,239 | 179,340 | -3,899 | 1.77 | 2.24 | +0.48 | sell |
| Velan Capital Investment Management LP | 506,754 | 446,255 | -60,499 | 5.05 | 6.43 | +1.38 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 166,147 | 78,234 | -87,913 | 0.59 | 0.31 | -0.29 | sell |
| Octagon Capital Advisors LP | 500,000 | 143,472 | -356,528 | 1.07 | 0.37 | -0.71 | sell |