| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 113,022 | 1,455,863 | +1,342,841 | 0.22 | 2.58 | +2.36 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 896,700 | +896,700 | 0.00 | 0.01 | +0.01 | buy |
| BAKER BROS. ADVISORS LP | 0 | 847,390 | +847,390 | 0.00 | 0.11 | +0.11 | buy |
| Alyeska Investment Group, L.P. | 0 | 726,362 | +726,362 | 0.00 | 0.05 | +0.05 | buy |
| BlackRock, Inc. | 142,440 | 673,571 | +531,131 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 448,350 | +448,350 | 0.00 | 0.20 | +0.20 | buy |
| Kynam Capital Management, LP | 185,482 | 625,496 | +440,014 | 0.21 | 0.91 | +0.71 | buy |
| Freestone Grove Partners LP | 0 | 337,291 | +337,291 | 0.00 | 0.06 | +0.06 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 782,121 | 1,119,021 | +336,900 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 298,375 | +298,375 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 961,525 | 1,209,129 | +247,604 | 0.26 | 0.46 | +0.20 | buy |
| E Fund Management Co., Ltd. | 0 | 243,700 | +243,700 | 0.00 | 0.17 | +0.17 | buy |
| RTW INVESTMENTS, LP | 1,283,671 | 1,502,235 | +218,564 | 0.22 | 0.34 | +0.12 | buy |
| JPMORGAN CHASE & CO | 1,308,901 | 1,459,420 | +150,519 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 31,500 | 179,511 | +148,011 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 109,781 | 248,611 | +138,830 | 0.00 | 0.00 | +0.00 | buy |
| STEMPOINT CAPITAL LP | 68,196 | 193,777 | +125,581 | 0.20 | 0.84 | +0.64 | buy |
| Integral Health Asset Management, LLC | 125,000 | 225,000 | +100,000 | 0.11 | 0.27 | +0.17 | buy |
| Blue Owl Capital Holdings LP | 0 | 100,000 | +100,000 | 0.00 | 0.62 | +0.62 | buy |
| ExodusPoint Capital Management, LP | 0 | 93,913 | +93,913 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 61,675 | 154,323 | +92,648 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 75,000 | 164,670 | +89,670 | 0.10 | 0.25 | +0.16 | buy |
| AMERICAN CENTURY COMPANIES INC | 417,455 | 492,938 | +75,483 | 0.00 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 22,636 | 79,755 | +57,119 | 0.00 | 0.00 | +0.00 | buy |
| Propel Bio Management, LLC | 0 | 55,664 | +55,664 | 0.00 | 0.81 | +0.81 | buy |
| Eversept Partners, LP | 0 | 54,680 | +54,680 | 0.00 | 0.08 | +0.08 | buy |
| Hudson Bay Capital Management LP | 0 | 51,364 | +51,364 | 0.00 | 0.01 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 3,458,770 | 3,494,638 | +35,868 | 0.61 | 0.85 | +0.24 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 62,704 | 94,948 | +32,244 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 30,201 | +30,201 | 0.00 | 0.00 | +0.00 | buy |
| Palumbo Wealth Management LLC | 0 | 29,931 | +29,931 | 0.00 | 0.17 | +0.17 | buy |
| Bank of New York Mellon Corp | 0 | 22,091 | +22,091 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 0 | 12,452 | +12,452 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 0 | 11,821 | +11,821 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 0 | 6,031 | +6,031 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 0 | 4,881 | +4,881 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 4,300 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 3,867 | +3,867 | 0.00 | 0.00 | +0.00 | buy |
| Police & Firemen's Retirement System of New Jersey | 0 | 3,006 | +3,006 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,000 | 5,000 | +3,000 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 10,225 | 12,812 | +2,587 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 2,200 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 34,384 | 36,577 | +2,193 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 1,978 | +1,978 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 1,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 0 | 1,719 | +1,719 | 0.00 | 0.00 | +0.00 | buy |
| Plante Moran Financial Advisors, LLC | 0 | 1,147 | +1,147 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 0 | 855 | +855 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 788 | +788 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 0 | 571 | +571 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 400 | 919 | +519 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 0 | 518 | +518 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 2,200 | 2,400 | +200 | 0.00 | 0.00 | +0.00 | buy |
| FIFTH THIRD BANCORP | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 325,000 | 325,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| SECTORAL ASSET MANAGEMENT INC | 589,005 | 589,005 | 0 | 8.08 | 11.22 | +3.13 | hold |
| GREAT POINT PARTNERS LLC | 325,000 | 325,000 | 0 | 1.80 | 1.83 | +0.03 | hold |
| Nan Fung Group Holdings Ltd | 1,441,032 | 1,441,032 | 0 | 22.08 | 27.32 | +5.24 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,926,943 | 1,926,943 | 0 | 12.75 | 15.83 | +3.08 | hold |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.06 | 0.06 | +0.00 | hold |
| ADAR1 Capital Management, LLC | 184,062 | 184,062 | 0 | 0.24 | 0.25 | +0.02 | hold |
| Tower Research Capital LLC (TRC) | 2,745 | 2,249 | -496 | 0.00 | 0.00 | +0.00 | sell |
| Monashee Investment Management LLC | 183,239 | 179,340 | -3,899 | 1.77 | 2.24 | +0.48 | sell |
| TD ASSET MANAGEMENT INC | 44,634 | 40,210 | -4,424 | 0.00 | 0.00 | +0.00 | sell |
| XTX Topco Ltd | 18,778 | 12,040 | -6,738 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 104,555 | 91,429 | -13,126 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 565,214 | 549,991 | -15,223 | 0.05 | 0.12 | +0.07 | sell |
| OXFORD ASSET MANAGEMENT LLP | 19,565 | 0 | -19,565 | 0.12 | 0.00 | -0.12 | sell |
| TWO SIGMA INVESTMENTS, LP | 21,324 | 0 | -21,324 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 24,057 | 0 | -24,057 | 0.00 | 0.00 | -0.00 | sell |
| TUDOR INVESTMENT CORP ET AL | 31,953 | 0 | -31,953 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 50,560 | 0 | -50,560 | 0.00 | 0.00 | -0.00 | sell |
| Capricorn Fund Managers Ltd | 60,000 | 0 | -60,000 | 0.25 | 0.00 | -0.25 | sell |
| Velan Capital Investment Management LP | 506,754 | 446,255 | -60,499 | 5.05 | 6.43 | +1.38 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 65,000 | 0 | -65,000 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 166,147 | 78,234 | -87,913 | 0.59 | 0.31 | -0.29 | sell |
| MARSHALL WACE, LLP | 988,200 | 879,728 | -108,472 | 0.02 | 0.02 | +0.01 | sell |
| Sofinnova Investments, Inc. | 153,320 | 0 | -153,320 | 0.11 | 0.00 | -0.11 | sell |
| Octagon Capital Advisors LP | 500,000 | 143,472 | -356,528 | 1.07 | 0.37 | -0.71 | sell |
| Aberdeen Group plc | 525,376 | 0 | -525,376 | 0.01 | 0.00 | -0.01 | sell |