| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 36,577 | 1,435,049 | +1,398,472 | 0.00 | 0.03 | +0.03 | buy |
| Vestal Point Capital, LP | 0 | 1,000,000 | +1,000,000 | 0.00 | 0.31 | +0.31 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,119,021 | 1,940,939 | +821,918 | 0.00 | 0.00 | -0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 457,015 | +457,015 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 0 | 290,174 | +290,174 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 492,938 | 755,018 | +262,080 | 0.01 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 232,440 | +232,440 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 673,571 | 886,538 | +212,967 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 1,978 | 178,730 | +176,752 | 0.00 | 0.00 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 0 | 161,000 | +161,000 | 0.00 | 0.04 | +0.04 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 133,072 | +133,072 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 2,200 | 133,350 | +131,150 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 54,680 | 174,460 | +119,780 | 0.08 | 0.13 | +0.04 | buy |
| LMR Partners LLP | 0 | 118,436 | +118,436 | 0.00 | 0.01 | +0.01 | buy |
| Longaeva Partners L.P. | 0 | 116,611 | +116,611 | 0.00 | 0.04 | +0.04 | buy |
| UBS Group AG | 298,375 | 413,553 | +115,178 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 179,511 | 293,516 | +114,005 | 0.00 | 0.00 | -0.00 | buy |
| Holocene Advisors, LP | 0 | 111,132 | +111,132 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,459,420 | 1,553,132 | +93,712 | 0.00 | 0.00 | -0.00 | buy |
| Blue Owl Capital Holdings LP | 100,000 | 180,000 | +80,000 | 0.62 | 0.36 | -0.25 | buy |
| Avidity Partners Management LP | 0 | 75,000 | +75,000 | 0.00 | 0.16 | +0.16 | buy |
| Quadrature Capital Ltd | 0 | 69,311 | +69,311 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 248,611 | 301,759 | +53,148 | 0.00 | 0.00 | -0.00 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 51,796 | +51,796 | 0.00 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 12,040 | 60,694 | +48,654 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 47,702 | +47,702 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 154,323 | 192,995 | +38,672 | 0.00 | 0.00 | -0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 94,948 | 133,072 | +38,124 | 0.00 | 0.00 | -0.00 | buy |
| ALPS ADVISORS INC | 0 | 36,558 | +36,558 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 30,581 | +30,581 | 0.00 | 0.01 | +0.01 | buy |
| Jump Financial, LLC | 0 | 30,200 | +30,200 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 30,115 | +30,115 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 28,398 | +28,398 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 12,812 | 38,908 | +26,096 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 25,526 | +25,526 | 0.00 | 0.00 | +0.00 | buy |
| J. Safra Sarasin Holding AG | 0 | 24,217 | +24,217 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 23,558 | +23,558 | 0.00 | 0.01 | +0.01 | buy |
| Swiss National Bank | 0 | 21,700 | +21,700 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 79,755 | 101,404 | +21,649 | 0.00 | 0.00 | -0.00 | buy |
| TD ASSET MANAGEMENT INC | 40,210 | 60,662 | +20,452 | 0.00 | 0.00 | -0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 16,500 | +16,500 | 0.00 | 0.05 | +0.05 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 15,760 | +15,760 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 0 | 12,611 | +12,611 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 571 | 11,660 | +11,089 | 0.00 | 0.00 | +0.00 | buy |
| Nuveen, LLC | 12,452 | 20,899 | +8,447 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 3,867 | 12,066 | +8,199 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 7,640 | +7,640 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 919 | 8,521 | +7,602 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 0 | 6,685 | +6,685 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 518 | 6,252 | +5,734 | 0.00 | 0.00 | +0.00 | buy |
| NATIXIS | 0 | 5,044 | +5,044 | 0.00 | 0.00 | +0.00 | buy |
| Velan Capital Investment Management LP | 446,255 | 451,255 | +5,000 | 6.43 | 3.67 | -2.75 | buy |
| Bank of New York Mellon Corp | 22,091 | 25,551 | +3,460 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 11,821 | 14,495 | +2,674 | 0.00 | 0.00 | -0.00 | buy |
| KLP KAPITALFORVALTNING AS | 0 | 2,400 | +2,400 | 0.00 | 0.00 | +0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 0 | 1,800 | +1,800 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 6,031 | 7,023 | +992 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 4,881 | 5,838 | +957 | 0.00 | 0.00 | -0.00 | buy |
| State of Wyoming | 0 | 838 | +838 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,249 | 2,872 | +623 | 0.00 | 0.00 | -0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 289 | +289 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 29 | +29 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 855 | 855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FEDERATED HERMES, INC. | 325,000 | 325,000 | 0 | 0.01 | 0.01 | -0.01 | hold |
| BAKER BROS. ADVISORS LP | 847,390 | 847,390 | 0 | 0.11 | 0.06 | -0.06 | hold |
| GREAT POINT PARTNERS LLC | 325,000 | 325,000 | 0 | 1.83 | 1.02 | -0.81 | hold |
| RA CAPITAL MANAGEMENT, L.P. | 3,494,638 | 3,494,638 | 0 | 0.85 | 0.40 | -0.45 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,209,129 | 1,209,129 | 0 | 0.46 | 0.21 | -0.25 | hold |
| RTW INVESTMENTS, LP | 1,502,235 | 1,502,235 | 0 | 0.34 | 0.17 | -0.17 | hold |
| Nan Fung Group Holdings Ltd | 1,441,032 | 1,441,032 | 0 | 27.32 | 14.56 | -12.75 | hold |
| Pivotal bioVenture Partners Investment Advisor LLC | 1,926,943 | 1,926,943 | 0 | 15.83 | 8.32 | -7.51 | hold |
| Burkehill Global Management, LP | 50,000 | 50,000 | 0 | 0.06 | 0.02 | -0.03 | hold |
| Police & Firemen's Retirement System of New Jersey | 3,006 | 3,006 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FIFTH THIRD BANCORP | 21 | 21 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 4,300 | 4,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Sterling Capital Management LLC | 200 | 45 | -155 | 0.00 | 0.00 | -0.00 | sell |
| Russell Investments Group, Ltd. | 788 | 0 | -788 | 0.00 | 0.00 | -0.00 | sell |
| Plante Moran Financial Advisors, LLC | 1,147 | 0 | -1,147 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,719 | 0 | -1,719 | 0.00 | 0.00 | -0.00 | sell |
| STRS OHIO | 1,800 | 0 | -1,800 | 0.00 | 0.00 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 2,400 | 0 | -2,400 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 91,429 | 87,018 | -4,411 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,000 | 0 | -5,000 | 0.01 | 0.00 | -0.01 | sell |
| Alyeska Investment Group, L.P. | 726,362 | 704,425 | -21,937 | 0.05 | 0.02 | -0.02 | sell |
| Palumbo Wealth Management LLC | 29,931 | 0 | -29,931 | 0.17 | 0.00 | -0.17 | sell |
| BANK OF AMERICA CORP /DE/ | 30,201 | 0 | -30,201 | 0.00 | 0.00 | -0.00 | sell |
| Freestone Grove Partners LP | 337,291 | 306,328 | -30,963 | 0.06 | 0.03 | -0.03 | sell |
| Hudson Bay Capital Management LP | 51,364 | 0 | -51,364 | 0.01 | 0.00 | -0.01 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 78,234 | 22,632 | -55,602 | 0.31 | 0.04 | -0.27 | sell |
| Propel Bio Management, LLC | 55,664 | 0 | -55,664 | 0.81 | 0.00 | -0.81 | sell |
| SEVEN GRAND MANAGERS, LLC | 164,670 | 90,568 | -74,102 | 0.25 | 0.05 | -0.20 | sell |
| ExodusPoint Capital Management, LP | 93,913 | 15,227 | -78,686 | 0.02 | 0.00 | -0.02 | sell |
| ADAR1 Capital Management, LLC | 184,062 | 104,035 | -80,027 | 0.25 | 0.06 | -0.19 | sell |
| Octagon Capital Advisors LP | 143,472 | 0 | -143,472 | 0.37 | 0.00 | -0.37 | sell |
| Monashee Investment Management LLC | 179,340 | 0 | -179,340 | 2.24 | 0.00 | -2.24 | sell |
| STEMPOINT CAPITAL LP | 193,777 | 0 | -193,777 | 0.84 | 0.00 | -0.84 | sell |
| Integral Health Asset Management, LLC | 225,000 | 0 | -225,000 | 0.27 | 0.00 | -0.27 | sell |
| E Fund Management Co., Ltd. | 243,700 | 0 | -243,700 | 0.17 | 0.00 | -0.17 | sell |