| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 3,458,770 | +3,458,770 | 0.00 | 0.61 | +0.61 | buy |
| Pivotal bioVenture Partners Investment Advisor LLC | 0 | 1,926,943 | +1,926,943 | 0.00 | 12.75 | +12.75 | buy |
| Nan Fung Group Holdings Ltd | 0 | 1,441,032 | +1,441,032 | 0.00 | 22.08 | +22.08 | buy |
| JPMORGAN CHASE & CO | 0 | 1,308,901 | +1,308,901 | 0.00 | 0.00 | +0.00 | buy |
| RTW INVESTMENTS, LP | 0 | 1,283,671 | +1,283,671 | 0.00 | 0.22 | +0.22 | buy |
| MARSHALL WACE, LLP | 0 | 988,200 | +988,200 | 0.00 | 0.02 | +0.02 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 961,525 | +961,525 | 0.00 | 0.26 | +0.26 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 782,121 | +782,121 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 589,005 | +589,005 | 0.00 | 8.08 | +8.08 | buy |
| Verition Fund Management LLC | 0 | 565,214 | +565,214 | 0.00 | 0.05 | +0.05 | buy |
| Aberdeen Group plc | 0 | 525,376 | +525,376 | 0.00 | 0.01 | +0.01 | buy |
| Velan Capital Investment Management LP | 0 | 506,754 | +506,754 | 0.00 | 5.05 | +5.05 | buy |
| VANGUARD GROUP INC | 0 | 502,574 | +502,574 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 0 | 500,000 | +500,000 | 0.00 | 1.07 | +1.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 417,455 | +417,455 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 325,000 | +325,000 | 0.00 | 0.01 | +0.01 | buy |
| GREAT POINT PARTNERS LLC | 0 | 325,000 | +325,000 | 0.00 | 1.80 | +1.80 | buy |
| Kynam Capital Management, LP | 0 | 185,482 | +185,482 | 0.00 | 0.21 | +0.21 | buy |
| ADAR1 Capital Management, LLC | 0 | 184,062 | +184,062 | 0.00 | 0.24 | +0.24 | buy |
| Monashee Investment Management LLC | 0 | 183,239 | +183,239 | 0.00 | 1.77 | +1.77 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 166,147 | +166,147 | 0.00 | 0.59 | +0.59 | buy |
| Sofinnova Investments, Inc. | 0 | 153,320 | +153,320 | 0.00 | 0.11 | +0.11 | buy |
| BlackRock, Inc. | 0 | 142,440 | +142,440 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 125,000 | +125,000 | 0.00 | 0.11 | +0.11 | buy |
| MPM BioImpact LLC | 0 | 113,022 | +113,022 | 0.00 | 0.22 | +0.22 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 109,781 | +109,781 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 104,555 | +104,555 | 0.00 | 0.00 | +0.00 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 75,000 | +75,000 | 0.00 | 0.10 | +0.10 | buy |
| STEMPOINT CAPITAL LP | 0 | 68,196 | +68,196 | 0.00 | 0.20 | +0.20 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 65,000 | +65,000 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 0 | 62,704 | +62,704 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 61,675 | +61,675 | 0.00 | 0.00 | +0.00 | buy |
| Capricorn Fund Managers Ltd | 0 | 60,000 | +60,000 | 0.00 | 0.25 | +0.25 | buy |
| CITADEL ADVISORS LLC | 0 | 50,560 | +50,560 | 0.00 | 0.00 | +0.00 | buy |
| Burkehill Global Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.06 | +0.06 | buy |
| TD ASSET MANAGEMENT INC | 0 | 44,634 | +44,634 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 34,384 | +34,384 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 31,953 | +31,953 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 0 | 31,500 | +31,500 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 24,057 | +24,057 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 0 | 22,636 | +22,636 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 21,324 | +21,324 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 19,565 | +19,565 | 0.00 | 0.12 | +0.12 | buy |
| XTX Topco Ltd | 0 | 18,778 | +18,778 | 0.00 | 0.01 | +0.01 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,225 | +10,225 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 2,745 | +2,745 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 2,200 | +2,200 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 2,000 | +2,000 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |